MX2016011674A - Combinacion que comprende un inhibidor de btk y un inhibidor de akt. - Google Patents
Combinacion que comprende un inhibidor de btk y un inhibidor de akt.Info
- Publication number
- MX2016011674A MX2016011674A MX2016011674A MX2016011674A MX2016011674A MX 2016011674 A MX2016011674 A MX 2016011674A MX 2016011674 A MX2016011674 A MX 2016011674A MX 2016011674 A MX2016011674 A MX 2016011674A MX 2016011674 A MX2016011674 A MX 2016011674A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitor
- akt
- btk
- combination
- chloro
- Prior art date
Links
- 229940124291 BTK inhibitor Drugs 0.000 title abstract 2
- 229940126638 Akt inhibitor Drugs 0.000 title 1
- 239000003197 protein kinase B inhibitor Substances 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- AFJRDFWMXUECEW-LBPRGKRZSA-N N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methyl-3-pyrazolyl)-2-thiophenecarboxamide Chemical compound CN1N=CC(Cl)=C1C1=C(Cl)SC(C(=O)N[C@H](CN)CC=2C=C(F)C=CC=2)=C1 AFJRDFWMXUECEW-LBPRGKRZSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una combinación novedosa que comprende un inhibidor de BTK, por ejemplo 1-[(3R)-3-[4-amino-3-(4-fenoxifenil)-1H-pirazolo[3,4-d]pir imidin-1-il] piperidin-1-il]prop-2-en-1-ona, o una sal farmacéuticamente aceptable del mismo, y un inhibidor de AKT, por ejemplo: N-{(1S)-2-amino-1-[(3-fluorofenil)metil]etil}-5-cloro-4-( 4-cloro-1-metil-1H-pirazol-5-il)-2-tiofencarboxamida, o una sal farmacéuticamente aceptable del mismo, y agentes antineoplásicos adicionales opcionales; composiciones farmacéuticas que comprenden los mismos y métodos de uso de tales combinaciones en el tratamiento de condiciones en las que la inhibición de BTK y/o AKT es beneficiosa, por ejemplo, cáncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461951640P | 2014-03-12 | 2014-03-12 | |
| PCT/IB2015/051380 WO2015136398A1 (en) | 2014-03-12 | 2015-02-24 | Combination comprising a btk inhibitor and an akt inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016011674A true MX2016011674A (es) | 2017-04-27 |
Family
ID=52630445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016011674A MX2016011674A (es) | 2014-03-12 | 2015-02-24 | Combinacion que comprende un inhibidor de btk y un inhibidor de akt. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20170020878A1 (es) |
| EP (1) | EP3116546A1 (es) |
| JP (1) | JP2017507963A (es) |
| KR (1) | KR20160127754A (es) |
| CN (1) | CN106456642A (es) |
| AU (1) | AU2015228475B9 (es) |
| CA (1) | CA2942204A1 (es) |
| MX (1) | MX2016011674A (es) |
| RU (1) | RU2016139697A (es) |
| WO (1) | WO2015136398A1 (es) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| AR064010A1 (es) | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
| UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| CN102405047B (zh) | 2009-01-30 | 2014-07-09 | 葛兰素史密斯克莱有限责任公司 | 结晶型的n-{(1s)-2-氨基-1-[(3-氟苯基)甲基]乙基}-5-氯-4-(4-氯-1-甲基-1h-吡唑-5-基)-2-噻吩甲酰胺盐酸盐 |
| ES2592152T3 (es) | 2010-05-31 | 2016-11-28 | Ono Pharmaceutical Co., Ltd. | Derivado de purinona como inhibidor de Btk quinasa |
| AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| ES2590491T3 (es) | 2011-05-17 | 2016-11-22 | F. Hoffmann-La Roche Ag | Inhibidores de la tirosina quinasa de Bruton |
| KR20140007954A (ko) | 2011-06-10 | 2014-01-20 | 메르크 파텐트 게엠베하 | Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법 |
| CA2841080A1 (en) * | 2011-07-13 | 2013-01-17 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| EP2734523A1 (en) | 2011-07-19 | 2014-05-28 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides btk-inhibitors |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| TW201325593A (zh) | 2011-10-28 | 2013-07-01 | Celgene Avilomics Res Inc | 治療布魯頓（ｂｒｕｔｏｎ’ｓ）酪胺酸激酶疾病或病症之方法 |
| BR112014010391A2 (pt) | 2011-11-03 | 2017-04-18 | Hoffmann La Roche | composto, composição farmacêutica, processo de produção de uma composição farmacêutica, método de tratamento, kit e uso de uma composição farmacêutica |
| JP5704252B2 (ja) | 2011-11-29 | 2015-04-22 | 小野薬品工業株式会社 | プリノン誘導体塩酸塩 |
| WO2013133367A1 (ja) | 2012-03-09 | 2013-09-12 | カルナバイオサイエンス株式会社 | 新規トリアジン誘導体 |
| WO2013161848A1 (ja) | 2012-04-27 | 2013-10-31 | カルナバイオサイエンス株式会社 | 新規１，２，４－トリアジン誘導体 |
| MX348290B (es) * | 2012-06-04 | 2017-06-05 | Pharmacyclics Llc | Formas cristalinas de un inhibidor de tirosina quinasa de bruton. |
| WO2013191965A1 (en) | 2012-06-18 | 2013-12-27 | Principia Biopharma Inc. | Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases |
-
2015
- 2015-02-24 RU RU2016139697A patent/RU2016139697A/ru not_active Application Discontinuation
- 2015-02-24 AU AU2015228475A patent/AU2015228475B9/en not_active Ceased
- 2015-02-24 EP EP15708605.9A patent/EP3116546A1/en not_active Withdrawn
- 2015-02-24 MX MX2016011674A patent/MX2016011674A/es unknown
- 2015-02-24 WO PCT/IB2015/051380 patent/WO2015136398A1/en not_active Ceased
- 2015-02-24 JP JP2016556821A patent/JP2017507963A/ja active Pending
- 2015-02-24 CN CN201580013442.2A patent/CN106456642A/zh active Pending
- 2015-02-24 US US15/124,301 patent/US20170020878A1/en not_active Abandoned
- 2015-02-24 CA CA2942204A patent/CA2942204A1/en not_active Abandoned
- 2015-02-24 KR KR1020167024720A patent/KR20160127754A/ko not_active Withdrawn
-
2018
- 2018-06-18 US US16/010,945 patent/US20190151319A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3116546A1 (en) | 2017-01-18 |
| AU2015228475B9 (en) | 2017-09-21 |
| CA2942204A1 (en) | 2015-09-17 |
| WO2015136398A1 (en) | 2015-09-17 |
| AU2015228475A1 (en) | 2016-09-01 |
| US20190151319A1 (en) | 2019-05-23 |
| RU2016139697A3 (es) | 2018-10-19 |
| US20170020878A1 (en) | 2017-01-26 |
| RU2016139697A (ru) | 2018-04-12 |
| KR20160127754A (ko) | 2016-11-04 |
| AU2015228475B2 (en) | 2017-08-17 |
| JP2017507963A (ja) | 2017-03-23 |
| CN106456642A (zh) | 2017-02-22 |
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