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MX2016011567A - Sintesis de clomifeno usando un solvente unico. - Google Patents

Sintesis de clomifeno usando un solvente unico.

Info

Publication number
MX2016011567A
MX2016011567A MX2016011567A MX2016011567A MX2016011567A MX 2016011567 A MX2016011567 A MX 2016011567A MX 2016011567 A MX2016011567 A MX 2016011567A MX 2016011567 A MX2016011567 A MX 2016011567A MX 2016011567 A MX2016011567 A MX 2016011567A
Authority
MX
Mexico
Prior art keywords
clomiphene
single solvent
synthesis
synthesizing
provides
Prior art date
Application number
MX2016011567A
Other languages
English (en)
Inventor
S Podolski Joseph
Hsu Kuang
Original Assignee
Repros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Repros Therapeutics Inc filed Critical Repros Therapeutics Inc
Publication of MX2016011567A publication Critical patent/MX2016011567A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención proporciona un método de un solo recipiente para la síntesis de clomifeno (una mezcla de los isómeros cis-clomifeno y trans-clomifeno) que utiliza un único solvente. En una modalidad preferida, el único solvente es diclorometano (DCM, también conocido como cloruro de metileno). La presente invención proporciona un método mejorado para sintetizar clomifeno y purificar isómeros de clomifeno.
MX2016011567A 2014-03-11 2015-03-09 Sintesis de clomifeno usando un solvente unico. MX2016011567A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461951316P 2014-03-11 2014-03-11
PCT/US2015/019493 WO2015138340A1 (en) 2014-03-11 2015-03-09 Clomiphene synthesis using a single solvent

Publications (1)

Publication Number Publication Date
MX2016011567A true MX2016011567A (es) 2016-12-07

Family

ID=54072298

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011567A MX2016011567A (es) 2014-03-11 2015-03-09 Sintesis de clomifeno usando un solvente unico.

Country Status (9)

Country Link
US (1) US9914696B2 (es)
EP (1) EP3116488A4 (es)
JP (1) JP2017507961A (es)
CN (1) CN106068121A (es)
AU (1) AU2015229742A1 (es)
CA (1) CA2942301A1 (es)
IL (1) IL247657A0 (es)
MX (1) MX2016011567A (es)
WO (1) WO2015138340A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107033013A (zh) * 2016-02-04 2017-08-11 上海度德医药科技有限公司 一种恩氯米芬的制备方法
CA2989364C (en) * 2016-04-22 2021-07-20 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit.
TWI793165B (zh) 2017-09-11 2023-02-21 美商阿托薩醫療公司 製造及使用因多昔芬(endoxifen)之方法
US12201591B2 (en) 2019-07-03 2025-01-21 Atossa Therapeutics, Inc. Sustained release compositions of endoxifen
CA3098552A1 (en) 2019-11-14 2021-05-14 Apotex Inc. Processes for the preparation of zuclomiphene and intermediates thereof
CA3098725A1 (en) 2019-11-14 2021-05-14 Apotex Inc. Zuclpomiphene salts and crystalline forms thereof
CA3105944A1 (en) 2020-01-22 2021-07-22 Apotex Inc. Crystalline forms of zuclomiphene citrate
EP3907213A1 (en) 2020-05-04 2021-11-10 Pcas Processes for the production of isomerically pure or enriched cis-clomiphene
US11578025B2 (en) 2020-10-19 2023-02-14 Apotex Inc. Processes for the preparation of zuclomiphene intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2914563A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Therapeutic composition
IT951631B (it) * 1971-03-18 1973-07-10 Richardson Merrell Spa Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi
US5589500A (en) * 1992-05-01 1996-12-31 British Technology Group Limited Substituted 1,1,2-triphenylbutenes and their use in the treatment of cancer
FI951193L (fi) * 1992-09-15 1995-03-14 Merrell Pharma Inc Ei-metabolisoituvat klomifeenianalogit tamoksifeeniresistenttien kasvainten hoitamiseksi
FI20030747A0 (fi) * 2003-05-19 2003-05-19 Orion Corp Toremifeenin kiteytysmenetelmä
CN103351304B (zh) * 2013-07-01 2015-12-09 暨明医药科技（苏州）有限公司 一种克罗米芬的合成方法

Also Published As

Publication number Publication date
US20170073302A1 (en) 2017-03-16
IL247657A0 (en) 2016-11-30
WO2015138340A1 (en) 2015-09-17
CN106068121A (zh) 2016-11-02
EP3116488A1 (en) 2017-01-18
AU2015229742A1 (en) 2016-10-06
EP3116488A4 (en) 2018-04-25
CA2942301A1 (en) 2015-09-17
US9914696B2 (en) 2018-03-13
JP2017507961A (ja) 2017-03-23

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