MX2016010871A - Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18. - Google Patents
Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18.Info
- Publication number
- MX2016010871A MX2016010871A MX2016010871A MX2016010871A MX2016010871A MX 2016010871 A MX2016010871 A MX 2016010871A MX 2016010871 A MX2016010871 A MX 2016010871A MX 2016010871 A MX2016010871 A MX 2016010871A MX 2016010871 A MX2016010871 A MX 2016010871A
- Authority
- MX
- Mexico
- Prior art keywords
- dosing regimen
- fgf
- weeks
- compound dosing
- new dosing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención proporciona un nuevo régimen de dosificación para la administración de FGF18 en el tratamiento de un trastorno del cartílago tal como, por ejemplo, la osteoartritis o la lesión del cartílago; se proporciona específicamente un plan de tratamiento preferido que comprende administraciones cada 3 semanas o cada 5 semanas de un compuesto de FGF-18 por ciclo de tratamiento; el nuevo régimen de dosificación puede incluir la co-administración de un fármaco anti-inflamatorio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14000600 | 2014-02-20 | ||
| PCT/EP2015/053624 WO2015124727A1 (en) | 2014-02-20 | 2015-02-20 | Fgf-18 compound dosing regimen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016010871A true MX2016010871A (es) | 2016-11-17 |
Family
ID=50151088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016010872A MX2016010872A (es) | 2014-02-20 | 2015-02-20 | Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18. |
| MX2016010871A MX2016010871A (es) | 2014-02-20 | 2015-02-20 | Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016010872A MX2016010872A (es) | 2014-02-20 | 2015-02-20 | Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9724388B2 (es) |
| EP (2) | EP3119417B1 (es) |
| JP (2) | JP6431082B2 (es) |
| KR (2) | KR102410988B1 (es) |
| CN (2) | CN106232622A (es) |
| AR (2) | AR099510A1 (es) |
| AU (2) | AU2015220773B2 (es) |
| BR (2) | BR112016018696A2 (es) |
| CA (2) | CA2938793A1 (es) |
| DK (2) | DK3119417T3 (es) |
| ES (2) | ES2688551T3 (es) |
| HR (2) | HRP20181570T1 (es) |
| HU (1) | HUE040350T2 (es) |
| IL (2) | IL247083B (es) |
| LT (2) | LT3107559T (es) |
| MX (2) | MX2016010872A (es) |
| NZ (1) | NZ723148A (es) |
| PL (2) | PL3119417T3 (es) |
| PT (2) | PT3119417T (es) |
| RS (2) | RS57853B1 (es) |
| RU (2) | RU2691946C2 (es) |
| SG (2) | SG11201606502YA (es) |
| SI (2) | SI3119417T1 (es) |
| WO (2) | WO2015124731A1 (es) |
| ZA (2) | ZA201605548B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ723177A (en) | 2014-02-20 | 2021-12-24 | Merck Patent Gmbh | Implant comprising fgf-18 |
| BR112016018696A2 (pt) | 2014-02-20 | 2017-10-17 | Merck Patent Gmbh | regime de dosagem com composto de fgf-18 |
| JP6787904B2 (ja) | 2015-01-29 | 2020-11-18 | アレス トレーディング ソシエテ アノニム | 高度に正に荷電したタンパク質のイムノアッセイ |
| RU2743075C2 (ru) | 2016-02-22 | 2021-02-15 | Новартис Аг | Способы применения агонистов fxr |
| US11467169B2 (en) * | 2017-09-29 | 2022-10-11 | Merck Patent Gmbh | Inflammatory biomarkers for predicting responsiveness to FGF-18 compound |
| US11513128B2 (en) | 2017-09-29 | 2022-11-29 | Merck Patent Gmbh | Metabolic biomarkers for predicting responsiveness to FGF-18 compound |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| WO2020161341A1 (en) * | 2019-02-08 | 2020-08-13 | Merck Patent Gmbh | Treatment of patients at risk of rapid progression of osteoarthritis |
| WO2025077768A1 (en) * | 2023-10-11 | 2025-04-17 | Sichuan Real & Best Biotech Co., Ltd. | Compositions and methods for treating arthritis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040136970A1 (en) * | 2002-10-07 | 2004-07-15 | Ellsworth Jeff L. | Methods for administering FGF18 |
| ES2706848T3 (es) * | 2004-07-06 | 2019-04-01 | Zymogenetics Inc | Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso |
| AU2006326870A1 (en) * | 2005-12-22 | 2007-06-28 | Apollo Life Sciences | Transdermal delivery of pharmaceutical agents |
| CA2658511C (en) * | 2006-08-25 | 2019-02-19 | Ares Trading S.A. | Use of fgf-18 compound to treat cartilage disorders |
| BRPI0715728A8 (pt) * | 2006-08-25 | 2018-04-03 | Ares Trading Sa | tratamento de distúrbios cartilaginosos |
| DE102006043260A1 (de) * | 2006-09-11 | 2008-03-27 | Krones Ag | Etikettieranlage |
| WO2012127506A1 (en) * | 2011-03-22 | 2012-09-27 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
| NZ723177A (en) | 2014-02-20 | 2021-12-24 | Merck Patent Gmbh | Implant comprising fgf-18 |
| WO2015124735A1 (en) | 2014-02-20 | 2015-08-27 | Merck Patent Gmbh | Fgf-18 in graft transplantation and tissue engineering procedures |
| BR112016018696A2 (pt) | 2014-02-20 | 2017-10-17 | Merck Patent Gmbh | regime de dosagem com composto de fgf-18 |
-
2015
- 2015-02-20 BR BR112016018696A patent/BR112016018696A2/pt not_active Application Discontinuation
- 2015-02-20 BR BR112016018685A patent/BR112016018685A2/pt not_active Application Discontinuation
- 2015-02-20 AU AU2015220773A patent/AU2015220773B2/en active Active
- 2015-02-20 US US15/120,134 patent/US9724388B2/en active Active
- 2015-02-20 KR KR1020167025245A patent/KR102410988B1/ko active Active
- 2015-02-20 JP JP2016553284A patent/JP6431082B2/ja active Active
- 2015-02-20 PL PL15707076T patent/PL3119417T3/pl unknown
- 2015-02-20 CN CN201580020536.2A patent/CN106232622A/zh active Pending
- 2015-02-20 CA CA2938793A patent/CA2938793A1/en active Pending
- 2015-02-20 ES ES15707076.4T patent/ES2688551T3/es active Active
- 2015-02-20 AU AU2015220777A patent/AU2015220777B2/en active Active
- 2015-02-20 WO PCT/EP2015/053631 patent/WO2015124731A1/en not_active Ceased
- 2015-02-20 DK DK15707076.4T patent/DK3119417T3/en active
- 2015-02-20 MX MX2016010872A patent/MX2016010872A/es active IP Right Grant
- 2015-02-20 DK DK15706006.2T patent/DK3107559T3/en active
- 2015-02-20 KR KR1020167025246A patent/KR102410986B1/ko active Active
- 2015-02-20 SG SG11201606502YA patent/SG11201606502YA/en unknown
- 2015-02-20 JP JP2016553329A patent/JP6431083B2/ja active Active
- 2015-02-20 HR HRP20181570TT patent/HRP20181570T1/hr unknown
- 2015-02-20 WO PCT/EP2015/053624 patent/WO2015124727A1/en not_active Ceased
- 2015-02-20 SI SI201530410T patent/SI3119417T1/sl unknown
- 2015-02-20 LT LTEP15706006.2T patent/LT3107559T/lt unknown
- 2015-02-20 PT PT15707076T patent/PT3119417T/pt unknown
- 2015-02-20 MX MX2016010871A patent/MX2016010871A/es active IP Right Grant
- 2015-02-20 CN CN201580020532.4A patent/CN106456713A/zh active Pending
- 2015-02-20 PL PL15706006T patent/PL3107559T3/pl unknown
- 2015-02-20 LT LTEP15707076.4T patent/LT3119417T/lt unknown
- 2015-02-20 HR HRP20181572TT patent/HRP20181572T1/hr unknown
- 2015-02-20 EP EP15707076.4A patent/EP3119417B1/en active Active
- 2015-02-20 SI SI201530428T patent/SI3107559T1/sl unknown
- 2015-02-20 CA CA2938791A patent/CA2938791A1/en not_active Abandoned
- 2015-02-20 RU RU2016137289A patent/RU2691946C2/ru active
- 2015-02-20 RS RS20181167A patent/RS57853B1/sr unknown
- 2015-02-20 SG SG11201606505UA patent/SG11201606505UA/en unknown
- 2015-02-20 AR ARP150100508A patent/AR099510A1/es unknown
- 2015-02-20 ES ES15706006.2T patent/ES2689071T3/es active Active
- 2015-02-20 RS RS20181168A patent/RS57709B1/sr unknown
- 2015-02-20 PT PT15706006T patent/PT3107559T/pt unknown
- 2015-02-20 AR ARP150100507A patent/AR099558A1/es unknown
- 2015-02-20 HU HUE15706006A patent/HUE040350T2/hu unknown
- 2015-02-20 NZ NZ723148A patent/NZ723148A/en unknown
- 2015-02-20 RU RU2016137292A patent/RU2700582C2/ru active
- 2015-02-20 EP EP15706006.2A patent/EP3107559B1/en active Active
- 2015-02-20 US US15/120,131 patent/US9889179B2/en active Active
-
2016
- 2016-08-03 IL IL247083A patent/IL247083B/en active IP Right Grant
- 2016-08-03 IL IL247084A patent/IL247084B/en active IP Right Grant
- 2016-08-10 ZA ZA2016/05548A patent/ZA201605548B/en unknown
- 2016-08-10 ZA ZA2016/05547A patent/ZA201605547B/en unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |