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MX2016010571A - Pirazolil-ureas como inhibidores de quinasas. - Google Patents

Pirazolil-ureas como inhibidores de quinasas.

Info

Publication number
MX2016010571A
MX2016010571A MX2016010571A MX2016010571A MX2016010571A MX 2016010571 A MX2016010571 A MX 2016010571A MX 2016010571 A MX2016010571 A MX 2016010571A MX 2016010571 A MX2016010571 A MX 2016010571A MX 2016010571 A MX2016010571 A MX 2016010571A
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
ureas
pyrazolyl
medicaments
formula
Prior art date
Application number
MX2016010571A
Other languages
English (en)
Other versions
MX371312B (es
Inventor
Iain Walters
John King-Underwood
Stuart Thomas Onions
Alistair Ian Longshaw
Jennifer Diane Venable
Euan Alexander Fraser Fordyce
Original Assignee
Respivert Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Respivert Ltd filed Critical Respivert Ltd
Publication of MX2016010571A publication Critical patent/MX2016010571A/es
Publication of MX371312B publication Critical patent/MX371312B/es

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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Orthopedic Medicine & Surgery (AREA)
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  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proveen compuestos de la fórmula (I) según se define en la memoria descriptiva que son inhibidores de p38 MAP quinasa para usar como medicamentos para el tratamiento inter alia de enfermedades inflamatorias.
MX2016010571A 2014-02-14 2015-02-13 Pirazolil-ureas como inhibidores de quinasas. MX371312B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461940282P 2014-02-14 2014-02-14
US201461941064P 2014-02-18 2014-02-18
PCT/GB2015/050401 WO2015121660A1 (en) 2014-02-14 2015-02-13 Pyrazolyl-ureas as kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2016010571A true MX2016010571A (es) 2017-01-05
MX371312B MX371312B (es) 2020-01-24

Family

ID=52573661

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016010572A MX371353B (es) 2014-02-14 2015-02-13 Compuestos heterociclicos aromaticos como compuestos antiinflamatorios.
MX2016010571A MX371312B (es) 2014-02-14 2015-02-13 Pirazolil-ureas como inhibidores de quinasas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016010572A MX371353B (es) 2014-02-14 2015-02-13 Compuestos heterociclicos aromaticos como compuestos antiinflamatorios.

Country Status (20)

Country Link
US (8) US9447076B2 (es)
EP (4) EP3105222B1 (es)
JP (4) JP6630280B2 (es)
KR (1) KR102413704B1 (es)
CN (4) CN113264921B (es)
AU (3) AU2015216705B2 (es)
BR (1) BR112016015838B1 (es)
CA (1) CA2938924C (es)
DK (2) DK3105222T3 (es)
EA (1) EA034927B1 (es)
ES (2) ES2677595T3 (es)
JO (1) JO3392B1 (es)
MX (2) MX371353B (es)
PL (2) PL3105222T3 (es)
PT (2) PT3105222T (es)
SG (1) SG11201607058PA (es)
TR (1) TR201809072T4 (es)
TW (2) TWI751099B (es)
UY (1) UY35998A (es)
WO (2) WO2015121444A1 (es)

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* Cited by examiner, † Cited by third party
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NZ586418A (en) 2007-12-19 2012-09-28 Cancer Rec Tech Ltd Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
EP2531502B1 (en) 2010-02-01 2014-04-02 Cancer Research Technology Limited 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
WO2013050757A1 (en) 2011-10-03 2013-04-11 Respivert Limited 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors
EP2578582A1 (en) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
EP2890695A2 (en) 2012-08-29 2015-07-08 Respivert Limited Kinase inhibitors
EP2890701B1 (en) 2012-08-29 2017-03-29 Respivert Limited Kinase inhibitors
EP2890460B1 (en) 2012-08-29 2017-02-22 Respivert Limited Kinase inhibitors
EP2925742B1 (en) 2012-11-16 2016-10-26 Respivert Limited Kinase inhibitors
EP2970190A1 (en) 2013-03-14 2016-01-20 Respivert Limited Kinase inhibitors
EP2981534B1 (en) 2013-04-02 2017-07-19 Topivert Pharma Limited Kinase inhibitors based upon n-alkyl pyrazoles
DK2981526T3 (da) 2013-04-02 2022-02-07 Oxular Acquisitions Ltd Naphthylureaderivater til anvendelse som kinaseinhibitorer
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
US9890185B2 (en) 2013-12-20 2018-02-13 Respivert Limited Urea derivatives useful as kinase inhibitors
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