MX2016006657A - Antagonistas de gastrina (por ejemplo, yf476, netazepido) para el tratamiento y prevencion de osteoporosis. - Google Patents
Antagonistas de gastrina (por ejemplo, yf476, netazepido) para el tratamiento y prevencion de osteoporosis.Info
- Publication number
- MX2016006657A MX2016006657A MX2016006657A MX2016006657A MX2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A
- Authority
- MX
- Mexico
- Prior art keywords
- gastrin
- prevention
- treatment
- netazepide
- osteoporosis
- Prior art date
Links
- 102100021022 Gastrin Human genes 0.000 title abstract 6
- 108010052343 Gastrins Proteins 0.000 title abstract 6
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 title abstract 6
- 239000005557 antagonist Substances 0.000 title abstract 2
- YDZYKNJZCVIKPP-VWLOTQADSA-N netazepide Chemical compound CNC1=CC=CC(NC(=O)N[C@H]2C(N(CC(=O)C(C)(C)C)C3=CC=CC=C3C(C=3N=CC=CC=3)=N2)=O)=C1 YDZYKNJZCVIKPP-VWLOTQADSA-N 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000001132 Osteoporosis Diseases 0.000 title 1
- 229950010986 netazepide Drugs 0.000 title 1
- 208000020084 Bone disease Diseases 0.000 abstract 3
- 206010060377 Hypergastrinaemia Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 239000003743 cholecystokinin B receptor antagonist Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Las modalidades proporcionadas se basan en algunos aspectos en la demostración en la presente de un papel para la gastrina en la regulación del envejecimiento del eje de los intestinos-ovarios, y en los efectos de dirigir la actividad de la gastrina en la reversión de la pérdida ósea mediada por la gastrina; se proporcionan métodos, composiciones y agentes, incluyendo antagonistas de gastrina, por ejemplo antagonista del receptor CCK2 (en particular YF476), para el tratamiento, la mejora y la prevención de enfermedades y condiciones óseas; los métodos para el tratamiento de una enfermedad o condición ósea asociada con hipergastrinemia en un sujeto en necesidad del mismo, pueden comprender la administración al sujeto de al menos una dosis de una cantidad terapéuticamente eficaz de un agente dirigido al receptor de gastrina, tratando así la enfermedad o condición ósea asociada con la hipergastrinemia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361907980P | 2013-11-22 | 2013-11-22 | |
| PCT/US2014/066832 WO2015077572A1 (en) | 2013-11-22 | 2014-11-21 | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016006657A true MX2016006657A (es) | 2016-10-12 |
Family
ID=52118000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006657A MX2016006657A (es) | 2013-11-22 | 2014-11-21 | Antagonistas de gastrina (por ejemplo, yf476, netazepido) para el tratamiento y prevencion de osteoporosis. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10709714B2 (es) |
| EP (1) | EP3071206B1 (es) |
| JP (1) | JP6502939B2 (es) |
| KR (1) | KR102254957B1 (es) |
| CN (1) | CN106163527A (es) |
| AU (1) | AU2014352875B2 (es) |
| BR (1) | BR112016011727A2 (es) |
| CA (1) | CA2929858C (es) |
| DK (1) | DK3071206T3 (es) |
| ES (1) | ES2870538T3 (es) |
| MX (1) | MX2016006657A (es) |
| PL (1) | PL3071206T3 (es) |
| RU (1) | RU2693484C1 (es) |
| WO (1) | WO2015077572A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10881667B2 (en) | 2018-10-30 | 2021-01-05 | City University Of Hong Kong | Method and composition for treating epilepsy |
| US11285161B2 (en) | 2019-04-26 | 2022-03-29 | City University Of Hong Kong | Method and composition for treating mental disorder and pain associated with nerve damage |
| CN110935005A (zh) * | 2019-11-19 | 2020-03-31 | 宁波大学 | 一种丙谷二肽的新用途 |
| CN115770266B (zh) * | 2023-01-30 | 2023-05-09 | 云南中医药大学 | 一种用于治疗绝经后骨质疏松的药物组合物 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0348523A4 (en) | 1987-12-22 | 1991-10-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compounds and their medicinal use |
| EP0411668B2 (en) | 1989-08-04 | 1998-11-11 | MERCK SHARP & DOHME LTD. | Central cholecystokinin antagonists for treatment of psychiatric disorders |
| US5399565A (en) | 1990-07-17 | 1995-03-21 | Eli Lilly And Company | Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations therof |
| WO1992011246A1 (en) | 1990-12-25 | 1992-07-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzodiazepine derivative |
| CA2110986A1 (en) | 1991-07-12 | 1993-01-21 | Geoffrey Neil Woodruff | Cholecystokinin antagonists useful in the treatment of panic attacks |
| EP0638560A4 (en) * | 1991-10-11 | 1995-03-29 | Yoshitomi Pharmaceutical | MEDICINE FOR OSTEOPOROSIS AND DIAZEPINE COMPOUND *. |
| WO1993012817A1 (en) * | 1991-12-20 | 1993-07-08 | Warner-Lambert Company | Therapeutic combinations useful in the treatment of gastroesophageal reflux disease |
| IL104853A (en) | 1992-02-27 | 1997-11-20 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them |
| MY128102A (en) | 1993-02-17 | 2007-01-31 | Chugai Pharmaceutical Co Ltd | Indolin-2-one-derivatives |
| GB2282595A (en) | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| IT1261255B (it) | 1993-09-09 | 1996-05-09 | Rotta Research Lab | Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. |
| US5750353A (en) | 1995-12-11 | 1998-05-12 | New England Medical Center Hospitals, Inc. | Assay for non-peptide agonists to peptide hormone receptors |
| WO1997021731A1 (en) | 1995-12-11 | 1997-06-19 | New England Medical Center Hospitals, Inc. | Assay for and uses of peptide hormone receptor ligands |
| US5922883A (en) | 1996-04-03 | 1999-07-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| NZ500748A (en) | 1997-05-12 | 2001-06-29 | Aphton Corp | Methods for the treatment of gastrin-dependent tumours comprising active or passive immunisation with an anti-CCK-B/gastrin receptor immunogen or anti-CCK-B/gastrin receptor antibodies |
| US20040001842A1 (en) | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
| WO1999059628A2 (en) | 1998-05-15 | 1999-11-25 | Aphton Corporation | Combination therapy for the treatment of tumors |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| JP2002517396A (ja) | 1998-06-04 | 2002-06-18 | アボット・ラボラトリーズ | 細胞接着阻害抗炎症性化合物 |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| ES2228451T3 (es) | 1999-01-29 | 2005-04-16 | Chugai Seiyaku Kabushiki Kaisha | Promotores de condrogenesis y derivados de indolin-2-ona. |
| WO2000075145A1 (en) | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US20030191279A1 (en) | 1999-08-27 | 2003-10-09 | Goldstein Steven Wayne | Urea derivatives useful as anticancer agents |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| CA2389685C (fr) | 1999-11-05 | 2011-07-12 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R) | Nouveaux composes heterocycliques et leur application a titre de medicaments |
| JP2003513995A (ja) | 1999-11-19 | 2003-04-15 | アクスクシーマ ファルマシューティカルス アクチェンゲゼルシャフト | ヘリコバクターピロリにより誘発される胃腸疾患の阻害剤 |
| AU2001253024A1 (en) | 2000-04-10 | 2001-10-23 | The General Hospital Corporation | Diagnosis and treatment of gastrointestinal disease |
| WO2002000651A2 (en) | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Factor xa inhibitors |
| AU2002252456A1 (en) | 2001-03-23 | 2002-10-08 | Aphton Corporation | Combination treatment of pancreatic cancer |
| US20040138285A1 (en) | 2001-04-27 | 2004-07-15 | Makoto Okazaki | Chondrogenesis promoters |
| US20090191232A1 (en) | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| CA2445477A1 (en) | 2001-05-11 | 2002-11-21 | Yamanouchi Pharmaceutical Co., Ltd. | Antitumor agents |
| AUPR738301A0 (en) | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
| HUP0402068A3 (en) | 2001-11-13 | 2005-09-28 | Black James Foundation | Benzotriazepines as gastrin and cholecystokinin receptor ligands, process for their preparation and pharmaceutical compositions containing them |
| JP2005529850A (ja) | 2002-02-19 | 2005-10-06 | ファルマシア・イタリア・エス・ピー・エー | 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用 |
| DE10207037A1 (de) | 2002-02-20 | 2003-08-28 | Bayer Cropscience Gmbh | 2-Amino-4-bicyclyamino-6H-1,3.5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| UA79804C2 (en) | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
| US20030049698A1 (en) | 2002-10-08 | 2003-03-13 | Wang Timothy C. | Diagnosis and treatment of gastrointestinal disease |
| WO2005012275A2 (en) | 2003-03-28 | 2005-02-10 | Janssen Pharmaceutica, N.V. | Benzo [1, 2, 5] thiadiazole compounds as cck2 modulators |
| GB0310865D0 (en) | 2003-05-12 | 2003-06-18 | Black James Foundation | Gastrin and cholecystokinin receptor ligands |
| US7524837B2 (en) | 2003-05-12 | 2009-04-28 | Janssen Pharmaceutica N.V. | Benzotriazapinone salts and methods for using same |
| US20050042283A1 (en) | 2003-07-11 | 2005-02-24 | University Of Massachusetts | Histamine and CCK2/gastrin receptor blockade in the treatment of acid-peptic disease and cancer |
| DK1651621T3 (da) | 2003-08-08 | 2008-11-10 | Janssen Pharmaceutica Nv | 2-(Quinoxalin-5-ylsulfonylamino)benzamidforbindelser som CCK2-modulatorer |
| WO2005090319A1 (en) | 2004-03-19 | 2005-09-29 | Arrow Therapeutics Limited | Process for preparing benzodiazepines |
| US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| US7947833B2 (en) | 2004-08-04 | 2011-05-24 | Janssen Pharmaceutica Nv | Preparation of quinoxaline compounds |
| AU2005289887A1 (en) | 2004-09-24 | 2006-04-06 | Janssen Pharmaceutica, N.V. | Sulfonamide compounds |
| WO2006044352A2 (en) | 2004-10-12 | 2006-04-27 | Janssen Pharmaceutica N.V. | Canine cholecystokinin 1 receptor materials and their use |
| WO2006049941A2 (en) | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as cb1 antagonists |
| JP2008519078A (ja) | 2004-11-04 | 2008-06-05 | ニューロゲン コーポレイション | Ｃｂ１拮抗薬としてのアリールアルキル尿素類 |
| GB0425196D0 (en) | 2004-11-15 | 2004-12-15 | Black James Foundation | Gastrin and cholecystokinin receptor ligands |
| ATE405262T1 (de) | 2004-12-17 | 2008-09-15 | Pfizer | Chroman-derivate als säurepumpenantagonisten |
| PT1839662E (pt) | 2005-01-19 | 2010-04-28 | Zeria Pharm Co Ltd | Agente antitumoral |
| AR053713A1 (es) | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| ES2423412T3 (es) | 2005-06-06 | 2013-09-20 | The Board Of Trustees Of The University Of Illinois | Composiciones y métodos para tratar los trastornos del sueño |
| CA2608582A1 (en) | 2005-06-14 | 2006-12-21 | Pfizer Inc. | Chromane substituted benzimidazole derivatives as acid pump antagonists |
| ES2324354T3 (es) | 2005-07-29 | 2009-08-05 | Rottapharm S.P.A. | Combinacion terapeutica de itriglumida e inhibidores de la bomba de protones en el tratamiento de trastornos gastrointestinales y relacionados. |
| WO2007026218A2 (en) | 2005-09-01 | 2007-03-08 | Pfizer Japan Inc. | Chromane substituted 2-alkyl imidazopyridine derivatives and use thereof as acid pump antagonists |
| WO2007031860A1 (en) | 2005-09-15 | 2007-03-22 | Pfizer Japan Inc. | Indane substituted benzimidazoles and their use as acid pump inhibitors |
| JP4481344B2 (ja) | 2005-12-19 | 2010-06-16 | ラクオリア創薬株式会社 | クロマン置換ベンゾイミダゾール誘導体及び酸ポンプ阻害剤としてのそれらの使用 |
| WO2007072142A2 (en) | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Benzimidazole-5-carboxamide derivatives |
| RU2008137145A (ru) | 2006-03-17 | 2010-03-27 | Раквалиа Фарма Инк. (Jp) | Производные хромана |
| CA2649000A1 (en) | 2006-04-12 | 2007-10-18 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | N-oxides of heterocyclic substituted bisarylureas for treating kinase-mediated diseases |
| FR2901473B1 (fr) | 2006-05-24 | 2010-08-13 | Oreal | Procede de defrisage des fibres keratiniques avec un moyen de chauffage et une amide |
| FR2901472B1 (fr) | 2006-05-24 | 2010-08-13 | Oreal | Procede de defrisage des fibres keratiniques avec un moyen de chauffage et des agents denaturants |
| BRPI0717102A2 (pt) | 2006-09-21 | 2013-10-29 | Raqualia Pharma Inc | Derivados de benzimidazol como inibidores seletivos de bomba de ácido |
| WO2008046082A2 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of heterocyclic compounds as therapeutic agents |
| WO2008059373A1 (es) | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Vacuna contra la malaria, basada en la subunidad 200l de la proteína msp1 de plasmodium vivax. |
| JP2008222557A (ja) | 2007-03-08 | 2008-09-25 | Kotobuki Seiyaku Kk | ピロロ［３，２−ｄ］ピリミジン誘導体及びこれを有効成分とする医薬組成物 |
| WO2008114123A1 (en) | 2007-03-21 | 2008-09-25 | Raqualia Pharma Inc. | Spiro benzimidazole derivatives as acid pump inhibitors |
| WO2008124518A1 (en) | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Oxo-dihydroisoindole sulfonamide compounds as modulators of the cck2 receptor |
| WO2008124524A2 (en) | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Aryl sulfonamide compounds as modulators of the cck2 receptor |
| ATE539063T1 (de) | 2007-06-26 | 2012-01-15 | Sanofi Sa | Regioselektive, kupferkatalysierte synthese von benzimidazolen und azabenzimidazolen |
| RU2379043C2 (ru) | 2007-08-02 | 2010-01-20 | Закрытое акционерное общество "Биологические исследования и системы" | Фармацевтическая композиция для профилактики и лечения остеопороза у женщин в период менопаузы |
| US20110105515A1 (en) | 2007-08-07 | 2011-05-05 | President And Fellows Of Harvard College | Targeting the oncoprotein nucleophosmin |
| AR073578A1 (es) | 2008-09-15 | 2010-11-17 | Priaxon Ag | Pirrolidin-2-onas |
| WO2010036316A1 (en) | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
| EP2415766A4 (en) | 2009-03-31 | 2012-11-21 | Zeria Pharm Co Ltd | METHOD FOR PRODUCING A BENZODIAZEPINE DERIVATIVE |
| RU2586276C2 (ru) | 2009-07-09 | 2016-06-10 | Раквалиа Фарма Инк. | Антагонист кислотного насоса для лечения заболеваний, связанных с патологическим нарушением моторики желудочно-кишечного тракта |
| CA2775204A1 (en) | 2009-09-24 | 2011-03-31 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Fused imidazo [3, 2 - d] pyraz ines as pi3 kinase inhibitors |
| AU2010303567B2 (en) | 2009-10-06 | 2016-06-09 | Millennium Pharmaceuticals, Inc | Heterocyclic compounds useful as PDK1 inhibitors |
| WO2011060304A2 (en) | 2009-11-13 | 2011-05-19 | Constar International, Inc. | Oxygen scavengers, compositions comprising the scavengers, and artcles made from the compositions |
| WO2011063164A2 (en) | 2009-11-18 | 2011-05-26 | Steady Sleep Rx Co., Inc. | Sustained release cannabinoid medicaments |
| BR112012026641A2 (pt) | 2010-04-23 | 2016-07-12 | Kineta Inc | compostos antivirais |
| EP2603098B1 (en) | 2010-08-12 | 2025-08-06 | Firmenich Incorporated | Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer |
| MX2013005564A (es) | 2010-11-18 | 2014-03-12 | Pier Pharmaceuticals | Medicamentos de canabinoides en bajas dosis. |
| US20120231083A1 (en) | 2010-11-18 | 2012-09-13 | The Board Of Trustees Of The University Of Illinois | Sustained release cannabinoid medicaments |
| DK2835131T3 (en) | 2010-12-14 | 2017-12-04 | Electrophoretics Ltd | Casein kinase 1 delta inhibitors (CK1 delta) |
| WO2013017479A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
| WO2013017480A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
| EP2780349B1 (en) | 2011-11-07 | 2019-02-27 | Massachusetts Institute of Technology | Tungsten oxo alkylidene complexes for z selective olefin metathesis |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| WO2013158928A2 (en) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
-
2014
- 2014-11-21 DK DK14815149.1T patent/DK3071206T3/da active
- 2014-11-21 WO PCT/US2014/066832 patent/WO2015077572A1/en not_active Ceased
- 2014-11-21 AU AU2014352875A patent/AU2014352875B2/en active Active
- 2014-11-21 KR KR1020167015759A patent/KR102254957B1/ko active Active
- 2014-11-21 CA CA2929858A patent/CA2929858C/en active Active
- 2014-11-21 MX MX2016006657A patent/MX2016006657A/es unknown
- 2014-11-21 CN CN201480073822.0A patent/CN106163527A/zh active Pending
- 2014-11-21 US US14/550,233 patent/US10709714B2/en active Active
- 2014-11-21 RU RU2016124538A patent/RU2693484C1/ru active
- 2014-11-21 EP EP14815149.1A patent/EP3071206B1/en active Active
- 2014-11-21 ES ES14815149T patent/ES2870538T3/es active Active
- 2014-11-21 JP JP2016533607A patent/JP6502939B2/ja active Active
- 2014-11-21 PL PL14815149T patent/PL3071206T3/pl unknown
- 2014-11-21 BR BR112016011727A patent/BR112016011727A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP6502939B2 (ja) | 2019-04-17 |
| KR102254957B1 (ko) | 2021-05-25 |
| EP3071206B1 (en) | 2021-02-17 |
| RU2016124538A (ru) | 2017-12-27 |
| RU2693484C1 (ru) | 2019-07-03 |
| CN106163527A (zh) | 2016-11-23 |
| US20150148339A1 (en) | 2015-05-28 |
| WO2015077572A1 (en) | 2015-05-28 |
| AU2014352875A8 (en) | 2016-06-30 |
| DK3071206T3 (da) | 2021-05-25 |
| AU2014352875B2 (en) | 2019-10-24 |
| KR20160088891A (ko) | 2016-07-26 |
| EP3071206A1 (en) | 2016-09-28 |
| CA2929858C (en) | 2022-03-29 |
| BR112016011727A2 (pt) | 2017-08-08 |
| PL3071206T3 (pl) | 2022-01-17 |
| CA2929858A1 (en) | 2015-05-28 |
| US10709714B2 (en) | 2020-07-14 |
| AU2014352875A1 (en) | 2016-05-26 |
| ES2870538T3 (es) | 2021-10-27 |
| JP2016538295A (ja) | 2016-12-08 |
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