MX2016006277A - Secuencia de endolisina kz144 modificada. - Google Patents
Secuencia de endolisina kz144 modificada.Info
- Publication number
- MX2016006277A MX2016006277A MX2016006277A MX2016006277A MX2016006277A MX 2016006277 A MX2016006277 A MX 2016006277A MX 2016006277 A MX2016006277 A MX 2016006277A MX 2016006277 A MX2016006277 A MX 2016006277A MX 2016006277 A MX2016006277 A MX 2016006277A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptides
- present
- nucleic acids
- relates
- sequence
- Prior art date
Links
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000589876 Campylobacter Species 0.000 abstract 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 abstract 1
- 108010013639 Peptidoglycan Proteins 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a polipéptidos que comprenden una secuencia de aminoácidos que presenta una identidad de secuencia de al menos aproximadamente un 90 % con la secuencia de SEQ ID NO: 1. Dichos polipéptidos degradan preferentemente al peptidoglucano de bacterias Gram-negativas, en particular, de bacterias Pseudomonas y/o Campylobacter. Además, la presente invención se refiere a ácidos nucleicos que codifican dichos polipéptidos, a vectores que comprenden dichos ácidos nucleicos y a las correspondientes células hospedadoras. Finalmente, la presente invención se refiere a composiciones que comprenden dichos polipéptidos, ácidos nucleicos, vectores y/o células hospedadoras de acuerdo con la presente invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/073869 WO2015070911A1 (en) | 2013-11-14 | 2013-11-14 | Modified kz144 endolysin sequence |
| PCT/EP2014/074671 WO2015071436A1 (en) | 2013-11-14 | 2014-11-14 | Modified kz144 endolysin sequence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016006277A true MX2016006277A (es) | 2017-01-05 |
| MX374403B MX374403B (es) | 2025-03-06 |
Family
ID=49582760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006277A MX374403B (es) | 2013-11-14 | 2014-11-14 | Secuencia de endolisina kz144 modificada. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10184120B2 (es) |
| JP (1) | JP6745720B2 (es) |
| KR (1) | KR102302044B1 (es) |
| CN (1) | CN105793419B (es) |
| AU (1) | AU2014350104B2 (es) |
| BR (1) | BR112016011091B1 (es) |
| CA (1) | CA2929686C (es) |
| EA (1) | EA035959B1 (es) |
| MX (1) | MX374403B (es) |
| WO (2) | WO2015070911A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018003101A (es) | 2015-09-17 | 2018-12-17 | Contrafect Corp | Activo de polipeptidos de lisina contra bacterias gram-negativas. |
| US20190125897A1 (en) * | 2016-04-28 | 2019-05-02 | Lysando Ag | Antimicrobial agents against salmonella bacteria |
| WO2017203471A1 (en) * | 2016-05-27 | 2017-11-30 | Sasinapas Co., Ltd. | Endolysin variant |
| WO2018100408A1 (en) * | 2016-11-30 | 2018-06-07 | Sasinapas Co.,Ltd. | Modified peptides |
| KR20200012844A (ko) * | 2017-04-03 | 2020-02-05 | 사시나파스 컴퍼니 리미티드 | 조작된 그람-음성 엔도리신 |
| CN112204054A (zh) * | 2018-05-30 | 2021-01-08 | 莱桑多公司 | 新抗微生物融合蛋白 |
| CN111304181B (zh) * | 2020-02-17 | 2021-11-23 | 华东理工大学 | 一种基因工程改造后的副溶血性弧菌噬菌体裂解酶及其制备方法和应用 |
| KR20250044545A (ko) | 2023-09-23 | 2025-04-01 | 조배근 | 사료급이기 청소기 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1289092C (en) * | 1987-01-15 | 1991-09-17 | Robert A. Hallewell | Thermostable human cu/zn superoxide dismutase muteins |
| EP0285123A3 (en) | 1987-04-03 | 1989-02-01 | Stabra AG | A method for complete mutagenesis of nucleic acids |
| ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
| JPH08127540A (ja) * | 1994-09-09 | 1996-05-21 | Takeda Chem Ind Ltd | 抗潰瘍医薬 |
| JP2010536354A (ja) * | 2007-08-22 | 2010-12-02 | ヒグロス インベスト ゲーエムベーハー | ヒトおよび動物のブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ）感染症において使用するための新しいタンパク質 |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| SI2445515T1 (sl) * | 2009-06-26 | 2016-08-31 | Lysando Ag | Antimikrobna sredstva |
| CN102482655B (zh) | 2009-06-26 | 2018-04-10 | 莱桑多公司 | 抗微生物剂 |
| US8846865B2 (en) * | 2009-08-24 | 2014-09-30 | Lysando Ag | Endolysin OBPgpLYS |
| CN103119158B (zh) * | 2010-04-27 | 2015-04-08 | 莱桑多公司 | 减少生物膜的方法 |
| GB201018518D0 (en) * | 2010-11-03 | 2010-12-15 | Univ Leuven Kath | Novel endolysin |
| EP2468856A1 (en) | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| KR20130142837A (ko) * | 2012-06-20 | 2013-12-30 | 한국외국어대학교 연구산학협력단 | 슈도모나스 에루기노사의 박테리오파아지 및 그 용도 |
-
2013
- 2013-11-14 WO PCT/EP2013/073869 patent/WO2015070911A1/en not_active Ceased
-
2014
- 2014-11-14 KR KR1020167015821A patent/KR102302044B1/ko active Active
- 2014-11-14 JP JP2016531660A patent/JP6745720B2/ja active Active
- 2014-11-14 AU AU2014350104A patent/AU2014350104B2/en active Active
- 2014-11-14 BR BR112016011091-9A patent/BR112016011091B1/pt not_active IP Right Cessation
- 2014-11-14 EA EA201691004A patent/EA035959B1/ru not_active IP Right Cessation
- 2014-11-14 MX MX2016006277A patent/MX374403B/es active IP Right Grant
- 2014-11-14 CA CA2929686A patent/CA2929686C/en active Active
- 2014-11-14 WO PCT/EP2014/074671 patent/WO2015071436A1/en not_active Ceased
- 2014-11-14 US US15/036,569 patent/US10184120B2/en active Active
- 2014-11-14 CN CN201480062330.1A patent/CN105793419B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA035959B1 (ru) | 2020-09-07 |
| WO2015071436A1 (en) | 2015-05-21 |
| NZ719338A (en) | 2022-03-25 |
| CA2929686A1 (en) | 2015-05-21 |
| AU2014350104A1 (en) | 2016-05-12 |
| EA201691004A1 (ru) | 2017-01-30 |
| JP2016537979A (ja) | 2016-12-08 |
| KR20160085342A (ko) | 2016-07-15 |
| CA2929686C (en) | 2023-08-08 |
| MX374403B (es) | 2025-03-06 |
| AU2014350104B2 (en) | 2020-03-05 |
| WO2015070911A1 (en) | 2015-05-21 |
| US20160281074A1 (en) | 2016-09-29 |
| US10184120B2 (en) | 2019-01-22 |
| BR112016011091A2 (pt) | 2017-12-05 |
| CN105793419A (zh) | 2016-07-20 |
| KR102302044B1 (ko) | 2021-09-15 |
| BR112016011091B1 (pt) | 2024-02-06 |
| JP6745720B2 (ja) | 2020-08-26 |
| CN105793419B (zh) | 2021-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |