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MX2016004142A - Moleculas de ácido ribonucleico pequeño de interferencia especifico de notch 1. - Google Patents

Moleculas de ácido ribonucleico pequeño de interferencia especifico de notch 1.

Info

Publication number
MX2016004142A
MX2016004142A MX2016004142A MX2016004142A MX2016004142A MX 2016004142 A MX2016004142 A MX 2016004142A MX 2016004142 A MX2016004142 A MX 2016004142A MX 2016004142 A MX2016004142 A MX 2016004142A MX 2016004142 A MX2016004142 A MX 2016004142A
Authority
MX
Mexico
Prior art keywords
nucleotide
acid molecules
ribonucleic acid
specific small
small interference
Prior art date
Application number
MX2016004142A
Other languages
English (en)
Other versions
MX377713B (es
Inventor
Schreiber Sören
Original Assignee
Soluventis Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Soluventis Gmbh filed Critical Soluventis Gmbh
Publication of MX2016004142A publication Critical patent/MX2016004142A/es
Publication of MX377713B publication Critical patent/MX377713B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

La presente invención se refiere a una molécula de ácido nucleico que comprende una estructura de doble hebra, en donde la estructura de doble hebra está formada por una primera hebra y una segunda hebra, en donde la primera hebra consiste de la siguiente secuencia de nucleótidos 5'acGaGcUgGaCcAcUgGuCdTSdT3', y la segunda hebra consiste de la siguiente secuencia de nucleótidos 5'GAcCaGuGgUcCaGcUcGudTSdT3', en donde un nucleótido menor indica que el nucleótido es 2'-F modificado y un nucleótido subrayado indica que el nucleótido es 2'-O-metilo modificado y en donde dTSdT indica que en el extremo 3' está unido un dinucleótido que consiste de dos nucleótidos dT, en donde dichos dos dTs están unidos covalentemente a través de un enlace de fosforotioato.
MX2016004142A 2013-09-30 2014-09-30 Moleculas de ácido ribonucleico pequeño de interferencia especifico de notch 1. MX377713B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13004722.8A EP2853595A1 (en) 2013-09-30 2013-09-30 NOTCH 1 specific siRNA molecules
PCT/EP2014/002655 WO2015043768A1 (en) 2013-09-30 2014-09-30 Notch 1 specific sirna molecule

Publications (2)

Publication Number Publication Date
MX2016004142A true MX2016004142A (es) 2016-10-13
MX377713B MX377713B (es) 2025-03-11

Family

ID=49304652

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016004142A MX377713B (es) 2013-09-30 2014-09-30 Moleculas de ácido ribonucleico pequeño de interferencia especifico de notch 1.

Country Status (16)

Country Link
US (2) US9896690B2 (es)
EP (2) EP2853595A1 (es)
JP (2) JP6561061B2 (es)
CN (2) CN111197046A (es)
AU (1) AU2014327809B2 (es)
CA (1) CA2924788A1 (es)
DK (1) DK3052625T3 (es)
HR (1) HRP20211525T1 (es)
HU (1) HUE056609T2 (es)
IL (1) IL244661B (es)
LT (1) LT3052625T (es)
MX (1) MX377713B (es)
RU (1) RU2651493C2 (es)
SG (2) SG11201602437VA (es)
SI (1) SI3052625T1 (es)
WO (1) WO2015043768A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2853595A1 (en) * 2013-09-30 2015-04-01 Soluventis GmbH NOTCH 1 specific siRNA molecules
CN115151644B (zh) * 2019-12-27 2024-06-21 国立大学法人神户大学 癌基因治疗药
CN112626068B (zh) * 2020-12-21 2021-12-03 徐州医科大学 一种靶向Notch1基因的LncRNA及其应用
CN116790603B (zh) * 2023-08-18 2023-10-31 成都中科奥格生物科技有限公司 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途

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US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
EP1695979B1 (en) 1991-12-24 2011-07-06 Isis Pharmaceuticals, Inc. Gapped modified oligonucleotides
EP1251170A3 (en) 1992-07-17 2002-10-30 Ribozyme Pharmaceuticals, Inc. Method and reagent for treatment of NF-kappaB dependent animal diseases
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
CA2326823A1 (en) 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
WO2000053722A2 (en) 1999-03-10 2000-09-14 Phogen Limited Delivery of nucleic acids and proteins to cells
BRPI0313202A8 (pt) 2002-08-05 2016-08-16 Atugen Ag Formas adicionais para interferir com as moléculas de rna
DK1771206T3 (en) 2004-05-05 2018-05-22 Silence Therapeutics Gmbh LIPIDS, LIPID COMPLEXES AND USE THEREOF
MX2010008326A (es) * 2008-01-29 2010-08-18 Proyecto Biomedicina Cima Sl Metodo y composiciones capaces de provocar un silenciamiento post-transcripcional de la expresion genica de forma sinergica.
WO2009114726A1 (en) * 2008-03-12 2009-09-17 Intradigm Corporation Compositions comprising notch1 sirna and methods of use thereof
EP2123256A1 (en) * 2008-05-19 2009-11-25 Ruhr-Universität Bochum Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer
CN102458366B (zh) * 2009-06-15 2015-02-11 阿尔尼拉姆医药品有限公司 靶向pcsk9基因的脂质配制的dsrna
JP2014528704A (ja) * 2011-08-03 2014-10-30 クォーク ファーマシューティカルズ インコーポレーティッドＱｕａｒｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 聴覚およびバランス障害を治療するための二本鎖オリゴヌクレオチド化合物
EP2802657B1 (en) * 2012-01-12 2018-05-02 Quark Pharmaceuticals, Inc. Combination therapy for treating hearing and balance disorders
EP2853595A1 (en) * 2013-09-30 2015-04-01 Soluventis GmbH NOTCH 1 specific siRNA molecules

Also Published As

Publication number Publication date
SI3052625T1 (sl) 2021-12-31
US10669548B2 (en) 2020-06-02
RU2651493C2 (ru) 2018-04-19
JP2019196384A (ja) 2019-11-14
HUE056609T2 (hu) 2022-02-28
JP6561061B2 (ja) 2019-08-14
AU2014327809A1 (en) 2016-04-07
US9896690B2 (en) 2018-02-20
CA2924788A1 (en) 2015-04-02
IL244661B (en) 2021-08-31
RU2016116931A (ru) 2017-11-10
EP3052625B1 (en) 2021-08-25
LT3052625T (lt) 2021-12-10
CN111197046A (zh) 2020-05-26
IL244661A0 (en) 2016-04-21
US20160215292A1 (en) 2016-07-28
CN105814202B (zh) 2020-03-06
AU2014327809B2 (en) 2021-11-18
JP2016533190A (ja) 2016-10-27
WO2015043768A1 (en) 2015-04-02
EP3052625A1 (en) 2016-08-10
JP7086039B2 (ja) 2022-06-17
DK3052625T3 (da) 2021-11-15
HRP20211525T1 (hr) 2021-12-24
WO2015043768A8 (en) 2016-05-12
SG10201802593WA (en) 2018-05-30
CN105814202A (zh) 2016-07-27
US20180237785A1 (en) 2018-08-23
MX377713B (es) 2025-03-11
SG11201602437VA (en) 2016-04-28
EP2853595A1 (en) 2015-04-01

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