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MX2016002582A - Metodo para producir celulas progenitoras hepaticas adultas. - Google Patents

Metodo para producir celulas progenitoras hepaticas adultas.

Info

Publication number
MX2016002582A
MX2016002582A MX2016002582A MX2016002582A MX2016002582A MX 2016002582 A MX2016002582 A MX 2016002582A MX 2016002582 A MX2016002582 A MX 2016002582A MX 2016002582 A MX2016002582 A MX 2016002582A MX 2016002582 A MX2016002582 A MX 2016002582A
Authority
MX
Mexico
Prior art keywords
cells
progenitor cells
adult liver
liver progenitor
producing
Prior art date
Application number
MX2016002582A
Other languages
English (en)
Other versions
MX369514B (es
Inventor
Sokal Etienne
Snykers Sarah
BARAN Tuba
Gellynck Kris
Original Assignee
Promethera Biosciences S A /N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promethera Biosciences S A /N V filed Critical Promethera Biosciences S A /N V
Publication of MX2016002582A publication Critical patent/MX2016002582A/es
Publication of MX369514B publication Critical patent/MX369514B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)

Abstract

La presente invención se refiere a novedosas células progenitoras hepáticas adultas (denominadas Células H2Stem), que han sido caracterizadas con base en una serie de actividades y marcadores biológicos. Los métodos de producción de células H2Stem permiten proporcionar dichas células en forma de células adherentes y en cúmulos de células tridimensionales en suspensión, que pueden ser diferenciadas en células con una fuerte actividad específica del hígado y/o que se pueden usar para el tratamiento de enfermedades hepáticas o para la evaluación de la eficacia, metabolismo y/o toxicidad de un compuesto.
MX2016002582A 2013-08-28 2014-08-28 Metodo para producir celulas progenitoras hepaticas adultas. MX369514B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361870983P 2013-08-28 2013-08-28
PCT/EP2014/068317 WO2015028577A1 (en) 2013-08-28 2014-08-28 Method for producing adult liver progenitor cells

Publications (2)

Publication Number Publication Date
MX2016002582A true MX2016002582A (es) 2016-10-26
MX369514B MX369514B (es) 2019-11-11

Family

ID=51659609

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016002582A MX369514B (es) 2013-08-28 2014-08-28 Metodo para producir celulas progenitoras hepaticas adultas.

Country Status (16)

Country Link
US (2) US10172889B2 (es)
EP (2) EP3039123B1 (es)
JP (2) JP6974941B2 (es)
KR (2) KR20190022939A (es)
CN (1) CN105658786B (es)
AU (1) AU2014314152B2 (es)
CA (1) CA2922247C (es)
DK (1) DK3039123T3 (es)
EA (1) EA034878B1 (es)
ES (1) ES2764408T3 (es)
IL (1) IL244205B (es)
MX (1) MX369514B (es)
PL (1) PL3039123T3 (es)
PT (1) PT3039123T (es)
SG (1) SG11201601485UA (es)
WO (1) WO2015028577A1 (es)

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WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
FI3140393T3 (fi) * 2014-08-28 2023-09-07 Cellaion Sa Menetelmä aikuisen maksan esisolujen tuottamiseksi
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
EP3401392B1 (en) 2016-01-08 2022-02-23 Evia Life Sciences Inc. Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound
MA45274A (fr) * 2016-03-02 2019-01-09 Univ Catholique Louvain Préparations améliorées de cellules progénitrices hépatiques adultes
CN116790476A (zh) 2016-05-05 2023-09-22 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
US11733234B2 (en) * 2016-07-12 2023-08-22 EMULATE, Inc. Compositions and methods of cell attachment
EP3534907A4 (en) 2016-11-04 2020-06-24 Children's Hospital Medical Center COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASES
US11492595B2 (en) * 2016-11-23 2022-11-08 Morphocell Technologies Inc. Encapsulated liver tissue
CA3045145A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
KR102107602B1 (ko) * 2017-05-29 2020-05-08 한양대학교 산학협력단 인간 성체 간세포 리프로그래밍 배지 조성물
KR20200028391A (ko) * 2017-06-12 2020-03-16 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 세포 생착용 패치 이식편 조성물
WO2019074793A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
WO2019219828A1 (en) * 2018-05-16 2019-11-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of culturing proliferative hepatocytes
CA3106634A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
US12428622B2 (en) 2018-09-12 2025-09-30 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
WO2020120664A1 (en) 2018-12-14 2020-06-18 Promethera Biosciences S.A./N.V. Cell composition comprising liver progenitor cells expressing hla-e
WO2020120666A1 (en) 2018-12-14 2020-06-18 Promethera Biosciences S.A./N.V. Liver progenitor cells expressing hla-g, and method for obtaining these cells compositions comprising said cells and their use
US20220202874A1 (en) 2019-03-26 2022-06-30 Promethera Therapeutics Sa Adult Liver Progenitor Cells for Treating Non-Alcoholic Fatty Liver Disease
US20220143100A1 (en) 2019-03-26 2022-05-12 Promethera Therapeutics S.A. Adult Liver Progenitor Cells for Treating Acute-On-Chronic Liver Failure
US20220220445A1 (en) 2019-04-30 2022-07-14 Promethera Therapeutics Sa Preparation of human allogeneic liver-derived progenitor cells
PL3963050T3 (pl) * 2019-04-30 2024-03-18 Cellaïon SA Przygotowanie ludzkich allogenicznych komórek progenitorowych pochodzących z wątroby
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN111394391B (zh) * 2019-07-11 2022-12-06 上海赛立维生物科技有限公司 肝祖细胞样细胞库的构建方法及其制备的细胞株与应用
AU2020364951A1 (en) 2019-10-09 2022-05-26 Cellaïon SA Use of liver progenitor or stem cells, lysates thereof, and/or conditioned medium in disorders characterized by vascular hyperpermeability
EP3881853A1 (en) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation
CN111778268B (zh) * 2020-06-03 2022-06-21 武汉仝干医疗科技股份有限公司 增强解毒功能基因片段及改造的HepG2细胞
US20230303979A1 (en) * 2020-08-14 2023-09-28 Iucf-Hyu (Industry-University Cooperation Foundation Hanyang Cell having gene corrected ex vivo and use thereof
CN113380343B (zh) * 2021-06-11 2023-10-31 中国食品药品检定研究院 基于oatp1b1和oatp1b3的何首乌中肝毒性化合物的快速筛选方法
WO2023180122A1 (en) 2022-03-24 2023-09-28 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence
US11898127B1 (en) 2022-09-26 2024-02-13 Upside Foods, Inc. Harvesting cell-based meat
WO2024200809A1 (en) 2023-03-31 2024-10-03 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing hepatocellular carcinoma

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FI3140393T3 (fi) 2014-08-28 2023-09-07 Cellaion Sa Menetelmä aikuisen maksan esisolujen tuottamiseksi

Also Published As

Publication number Publication date
CA2922247A1 (en) 2015-03-05
IL244205B (en) 2020-03-31
CN105658786A (zh) 2016-06-08
US20190134098A1 (en) 2019-05-09
JP2016530884A (ja) 2016-10-06
EA034878B1 (ru) 2020-04-01
AU2014314152A1 (en) 2016-03-17
PT3039123T (pt) 2020-01-16
EP3039123B1 (en) 2019-11-06
US20160206664A1 (en) 2016-07-21
CN105658786B (zh) 2020-07-03
WO2015028577A1 (en) 2015-03-05
JP6884908B2 (ja) 2021-06-09
EP3039123A1 (en) 2016-07-06
IL244205A0 (en) 2016-04-21
US10172889B2 (en) 2019-01-08
KR20160047523A (ko) 2016-05-02
CA2922247C (en) 2023-03-07
KR101954743B1 (ko) 2019-03-06
AU2014314152B2 (en) 2020-02-06
KR20190022939A (ko) 2019-03-06
PL3039123T3 (pl) 2021-07-19
SG11201601485UA (en) 2016-03-30
JP2020127429A (ja) 2020-08-27
MX369514B (es) 2019-11-11
JP6974941B2 (ja) 2021-12-01
EP3620514A1 (en) 2020-03-11
ES2764408T3 (es) 2020-06-03
EA201690398A1 (ru) 2016-08-31
DK3039123T3 (da) 2020-01-20

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