MX2016002208A - Polipeptidos de union a c5. - Google Patents
Polipeptidos de union a c5.Info
- Publication number
- MX2016002208A MX2016002208A MX2016002208A MX2016002208A MX2016002208A MX 2016002208 A MX2016002208 A MX 2016002208A MX 2016002208 A MX2016002208 A MX 2016002208A MX 2016002208 A MX2016002208 A MX 2016002208A MX 2016002208 A MX2016002208 A MX 2016002208A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- binding polypeptides
- eix10
- population
- sub
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Urology & Nephrology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente descripción se relaciona a un tipo de polipéptidos diseñados y proporciona un polipéptido que comprende la secuencia EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q. La presente descripción también se relaciona a poblaciones de polipéptidos variantes basados en un supercóntigo común, cada polipéptido en la población comprende la secuencia de aminoácidos EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q, y los métodos de selección de un polipéptido deseado que posea una afinidad por un blanco predeterminado a partir de dicha población.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13182022 | 2013-08-28 | ||
| PCT/EP2014/068259 WO2015028550A1 (en) | 2013-08-28 | 2014-08-28 | C5 binding polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016002208A true MX2016002208A (es) | 2016-06-28 |
| MX367423B MX367423B (es) | 2019-08-21 |
Family
ID=49034001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016002208A MX367423B (es) | 2013-08-28 | 2014-08-28 | Polipeptidos de union a c5. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9982022B2 (es) |
| EP (1) | EP3039033B1 (es) |
| JP (2) | JP7138411B2 (es) |
| KR (2) | KR102497083B1 (es) |
| CN (3) | CN105473606A (es) |
| AU (1) | AU2014314214C1 (es) |
| CA (1) | CA2920005C (es) |
| DK (1) | DK3039033T3 (es) |
| ES (1) | ES2742505T3 (es) |
| IL (1) | IL243849A0 (es) |
| LT (1) | LT3039033T (es) |
| MX (1) | MX367423B (es) |
| MY (1) | MY176200A (es) |
| PL (1) | PL3039033T3 (es) |
| PT (1) | PT3039033T (es) |
| RU (1) | RU2714156C2 (es) |
| TR (1) | TR201911279T4 (es) |
| WO (1) | WO2015028550A1 (es) |
| ZA (1) | ZA201600721B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20190522T1 (hr) | 2012-02-20 | 2019-05-03 | Swedish Orphan Biovitrum Ab (Publ) | Polipeptidi koji se vežu za humani komplement c5 |
| MX366425B (es) | 2013-03-15 | 2019-07-04 | Affibody Ab | Nuevos polipeptidos. |
| SG11201602679VA (en) * | 2013-08-28 | 2016-05-30 | Swedish Orphan Biovitrum Ab Publ | Stable polypeptides binding to human complement c5 |
| EP3193930B1 (en) * | 2014-09-17 | 2019-06-19 | Affibody AB | New polypeptides |
| US11498960B2 (en) | 2017-07-11 | 2022-11-15 | Alexion Pharmaceuticals, Inc. | Polypeptides that bind complement component C5 or serum albumin and fusion proteins thereof |
| KR20220044612A (ko) | 2019-03-22 | 2022-04-08 | 리플렉시온 파마슈티컬스, 인크. | Vegf에 대한 d-펩티드성 화합물 |
| CN120623341A (zh) | 2019-03-22 | 2025-09-12 | 反射制药有限公司 | 用于目标蛋白的多价d-肽化合物 |
| WO2021089695A1 (en) * | 2019-11-05 | 2021-05-14 | Affibody Ab | Polypeptides |
| WO2022171892A1 (en) | 2021-02-15 | 2022-08-18 | Affibody Ab | New her2-binding polypeptide |
| WO2023077139A1 (en) * | 2021-11-01 | 2023-05-04 | Ipc Research, Llc | Administration of c5-binding proteins |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| CA2096953A1 (en) * | 1990-11-26 | 1992-05-27 | Anthony Atkinson | Immunoglobulin-binding proteins and recombinant dna molecules coding therefor |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| SE9901379D0 (sv) * | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
| ATE449791T1 (de) | 2000-10-10 | 2009-12-15 | Genentech Inc | Inhibierung von c5 komplement-aktivierung für die behandlung und vorbeugung von xeno-transplantat oder akute vaskuläre abstossung |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| MXPA04001301A (es) | 2001-08-17 | 2004-07-08 | Tanox Inc | Inhibidores de la ruta del complemento que se unen a c5 y c5a son evitar la formacion de c5b. |
| ITMI20021527A1 (it) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
| EP1667702A2 (en) | 2003-09-10 | 2006-06-14 | Baxter International Inc., Baxter Healthcare Corp. | Peptides that inhibit complement activation |
| SE0400274D0 (sv) | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
| GB0518443D0 (en) | 2005-09-09 | 2005-10-19 | Evolutec Ltd | Method of treating myasthenia gravis |
| EP2359834B1 (en) | 2006-03-15 | 2016-11-09 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
| EP2190863B1 (en) | 2007-07-31 | 2015-09-02 | Affibody AB | New albumin binding compositions, methods and uses |
| US9187535B2 (en) | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
| ES2373832T3 (es) | 2007-12-19 | 2012-02-09 | Affibody Ab | Polipéptido derivado de proteína a y capaz de unirse a pdgf. |
| EP2077272A1 (en) * | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| AU2009279197B2 (en) | 2008-08-05 | 2013-12-12 | Novartis Ag | Compositions and methods for antibodies targeting complement protein C5 |
| WO2011056124A1 (en) * | 2009-11-04 | 2011-05-12 | Affibody Ab | Her3 binding polypeptides |
| EP2327725A1 (en) | 2009-11-26 | 2011-06-01 | InflaRx GmbH | Anti-C5a binding moieties with high blocking activity |
| BR112013000452A2 (pt) | 2010-07-09 | 2020-02-11 | Affibody Ab | Polipeptídeo de ligação de albumina, proteína de fusão ou conjugado, polinucleotídeo, método para produzir um polipeptídeo, composição, método para a preparação de uma composição, e, método para aumentar a solubilidade de um composto |
| WO2012074463A1 (en) | 2010-11-29 | 2012-06-07 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
| CN102127554B (zh) * | 2010-12-22 | 2012-07-25 | 南京农业大学 | 一种日本脑炎颗粒疫苗及其制备方法和应用 |
| US9005992B2 (en) | 2011-03-18 | 2015-04-14 | Postech Academy-Industry Foundation | Immobilizing fusion protein for effective and oriented immobilization of antibody on surfaces |
| HRP20190522T1 (hr) | 2012-02-20 | 2019-05-03 | Swedish Orphan Biovitrum Ab (Publ) | Polipeptidi koji se vežu za humani komplement c5 |
| JP5980104B2 (ja) | 2012-11-22 | 2016-08-31 | 三菱電機株式会社 | 液晶表示装置の製造方法および液晶表示装置の製造システム |
| EP2935335B1 (en) | 2012-12-19 | 2020-10-28 | Affibody AB | New polypeptides |
| SG11201602679VA (en) | 2013-08-28 | 2016-05-30 | Swedish Orphan Biovitrum Ab Publ | Stable polypeptides binding to human complement c5 |
-
2014
- 2014-08-28 CA CA2920005A patent/CA2920005C/en active Active
- 2014-08-28 TR TR2019/11279T patent/TR201911279T4/tr unknown
- 2014-08-28 AU AU2014314214A patent/AU2014314214C1/en active Active
- 2014-08-28 ES ES14755841T patent/ES2742505T3/es active Active
- 2014-08-28 LT LT14755841T patent/LT3039033T/lt unknown
- 2014-08-28 MX MX2016002208A patent/MX367423B/es active IP Right Grant
- 2014-08-28 KR KR1020227003426A patent/KR102497083B1/ko active Active
- 2014-08-28 CN CN201480046781.6A patent/CN105473606A/zh active Pending
- 2014-08-28 US US14/911,319 patent/US9982022B2/en not_active Ceased
- 2014-08-28 JP JP2016537294A patent/JP7138411B2/ja active Active
- 2014-08-28 DK DK14755841.5T patent/DK3039033T3/da active
- 2014-08-28 PT PT14755841T patent/PT3039033T/pt unknown
- 2014-08-28 US US16/840,882 patent/USRE49495E1/en active Active
- 2014-08-28 CN CN202410280105.0A patent/CN117964710A/zh active Pending
- 2014-08-28 KR KR1020167007561A patent/KR20160068744A/ko not_active Ceased
- 2014-08-28 CN CN202310964771.1A patent/CN116987154A/zh active Pending
- 2014-08-28 EP EP14755841.5A patent/EP3039033B1/en active Active
- 2014-08-28 MY MYPI2016700292A patent/MY176200A/en unknown
- 2014-08-28 WO PCT/EP2014/068259 patent/WO2015028550A1/en not_active Ceased
- 2014-08-28 RU RU2016108976A patent/RU2714156C2/ru not_active Application Discontinuation
- 2014-08-28 PL PL14755841T patent/PL3039033T3/pl unknown
-
2016
- 2016-01-28 IL IL243849A patent/IL243849A0/en active IP Right Grant
- 2016-02-02 ZA ZA2016/00721A patent/ZA201600721B/en unknown
-
2020
- 2020-07-01 JP JP2020113704A patent/JP2020180133A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |