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MX2016001927A - Antibióticos de péptidos lineales. - Google Patents

Antibióticos de péptidos lineales.

Info

Publication number
MX2016001927A
MX2016001927A MX2016001927A MX2016001927A MX2016001927A MX 2016001927 A MX2016001927 A MX 2016001927A MX 2016001927 A MX2016001927 A MX 2016001927A MX 2016001927 A MX2016001927 A MX 2016001927A MX 2016001927 A MX2016001927 A MX 2016001927A
Authority
MX
Mexico
Prior art keywords
compounds
antibiotcs
linear peptide
broad spectrum
bioactivity
Prior art date
Application number
MX2016001927A
Other languages
English (en)
Inventor
John Crawford James
I Higuchi Robert
Curran Roberts Tucker
Andrew Smith Peter
Paraselli Prasuna
F T Koehler Michael
Original Assignee
Rqx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rqx Pharmaceuticals Inc filed Critical Rqx Pharmaceuticals Inc
Publication of MX2016001927A publication Critical patent/MX2016001927A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)

Abstract

Se proporcionan en la presente compuestos antibacterianos, en donde los compuestos en algunas modalidades tienen una bioactividad de amplio espectro. Los compuestos proporcionados en la presente pueden, en otras modalidades, vencer la resistencia conferida por mutaciones sencillas de aminoácido en las posiciones definidas de las Peptidasas de Señal bacterianas (SPasas) y en otras modalidades proporcionar un amplio espectro de bioactividad antibiótica. También se proporcionan composiciones y métodos farmacéuticos para tratamiento usando los compuestos descritos en la presente.
MX2016001927A 2013-08-14 2014-08-14 Antibióticos de péptidos lineales. MX2016001927A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361865986P 2013-08-14 2013-08-14
US201361865980P 2013-08-14 2013-08-14
US201361865982P 2013-08-14 2013-08-14
PCT/US2014/051151 WO2015023898A1 (en) 2013-08-14 2014-08-14 Linear peptide antibiotcs

Publications (1)

Publication Number Publication Date
MX2016001927A true MX2016001927A (es) 2016-09-08

Family

ID=52468711

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016001927A MX2016001927A (es) 2013-08-14 2014-08-14 Antibióticos de péptidos lineales.

Country Status (9)

Country Link
US (1) US20160194358A1 (es)
EP (1) EP3033352A4 (es)
JP (1) JP2016528257A (es)
KR (1) KR20160044512A (es)
CN (1) CN105636978A (es)
CA (1) CA2921082A1 (es)
MX (1) MX2016001927A (es)
RU (1) RU2016107436A (es)
WO (1) WO2015023898A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3464336T3 (da) 2016-06-01 2022-05-09 Athira Pharma Inc Forbindelser
RU2698328C1 (ru) * 2019-02-27 2019-08-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Серебряные соли 5,6-диарил-4-[4-(ацетиламиносульфонил)фенил]-3,5-дигидропирроло[3,4-с]пиразол-3-онов, проявляющие противомикробную активность
CN111978371B (zh) * 2019-05-22 2022-05-13 成都诺和晟泰生物科技有限公司 一种多肽类衍生物及其在医药领域的用途
AU2020320034A1 (en) * 2019-07-30 2022-03-03 Karl-Franzens-Universität Graz Inhibitors of human ATGL
CN110606825A (zh) * 2019-10-30 2019-12-24 成都海杰亚医药科技有限公司 一种制备吡啶-2-硫醇的方法
CN110790817A (zh) * 2019-11-12 2020-02-14 成都诺和晟泰生物科技有限公司 一种多肽类化合物、制剂、药物组合物及制备方法、应用
CN116444378A (zh) * 2023-02-14 2023-07-18 广东优康精细化工有限公司 一种n-甲基异丙基胺的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0932617T1 (en) * 1996-10-18 2002-06-30 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
UA66767C2 (uk) * 1996-10-18 2004-06-15 Вертекс Фармасьютикалс Інкорпорейтед Інгібітори серин-протеаз, фармацевтична композиція, спосіб інгібування активності та спосіб лікування або профілактики вірусної інфекції гепатиту с
CN103159830B (zh) * 2011-12-15 2017-06-20 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物
WO2013123456A1 (en) * 2012-02-16 2013-08-22 Rqx Pharmaceuticals, Inc. Linear peptide antibiotics

Also Published As

Publication number Publication date
WO2015023898A8 (en) 2016-03-24
JP2016528257A (ja) 2016-09-15
CN105636978A (zh) 2016-06-01
RU2016107436A3 (es) 2018-05-22
KR20160044512A (ko) 2016-04-25
EP3033352A4 (en) 2017-04-19
US20160194358A1 (en) 2016-07-07
EP3033352A1 (en) 2016-06-22
RU2016107436A (ru) 2017-09-19
WO2015023898A1 (en) 2015-02-19
CA2921082A1 (en) 2015-02-19

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