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MX2016001901A - Biomarcadores para tratamiento de trastornos neoplasicos usando terapias dirigidas con andrógeno. - Google Patents

Biomarcadores para tratamiento de trastornos neoplasicos usando terapias dirigidas con andrógeno.

Info

Publication number
MX2016001901A
MX2016001901A MX2016001901A MX2016001901A MX2016001901A MX 2016001901 A MX2016001901 A MX 2016001901A MX 2016001901 A MX2016001901 A MX 2016001901A MX 2016001901 A MX2016001901 A MX 2016001901A MX 2016001901 A MX2016001901 A MX 2016001901A
Authority
MX
Mexico
Prior art keywords
treatment
androgen
biomarkers
targeted therapies
neoplastic disorders
Prior art date
Application number
MX2016001901A
Other languages
English (en)
Inventor
Njar Vincent
Zoubeidi Amina
Ferrante Karen
Corey Eva
Jacoby Douglas
Original Assignee
Tokai Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokai Pharmaceuticals Inc filed Critical Tokai Pharmaceuticals Inc
Publication of MX2016001901A publication Critical patent/MX2016001901A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen en la presente métodos y composiciones para el tratamiento de cáncer de próstata en un sujeto que necesita del mismo. El cáncer de próstata puede ser un cáncer de próstata resistente a castración y un cáncer de próstata resistente al antagonista del receptor de andrógeno. Los métodos pueden comprender administrar al sujeto un inhibidor de CYP17-liasa de la Fórmula II.
MX2016001901A 2013-08-12 2014-08-12 Biomarcadores para tratamiento de trastornos neoplasicos usando terapias dirigidas con andrógeno. MX2016001901A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361865038P 2013-08-12 2013-08-12
US201461990570P 2014-05-08 2014-05-08
US201462002110P 2014-05-22 2014-05-22
PCT/US2014/050793 WO2015023710A1 (en) 2013-08-12 2014-08-12 Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies

Publications (1)

Publication Number Publication Date
MX2016001901A true MX2016001901A (es) 2016-10-13

Family

ID=52468645

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016001901A MX2016001901A (es) 2013-08-12 2014-08-12 Biomarcadores para tratamiento de trastornos neoplasicos usando terapias dirigidas con andrógeno.

Country Status (13)

Country Link
US (2) US9808472B2 (es)
EP (1) EP3033088A4 (es)
JP (1) JP2016528252A (es)
KR (1) KR20160058774A (es)
CN (1) CN105636594A (es)
AU (1) AU2014306698A1 (es)
BR (1) BR112016002970A2 (es)
CA (1) CA2920317A1 (es)
IL (1) IL243419A0 (es)
MX (1) MX2016001901A (es)
RU (1) RU2016104643A (es)
SG (1) SG11201600525XA (es)
WO (1) WO2015023710A1 (es)

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CA2721506C (en) 2008-04-16 2019-09-17 Jun Luo Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants
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US9808472B2 (en) 2013-08-12 2017-11-07 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
JP6735236B2 (ja) 2014-05-12 2020-08-05 ヤンセン ファーマシューティカ エヌ．ベー． 酢酸アビラテロン治療の対象となる患者を同定するための生物学的マーカー
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WO2016033114A1 (en) * 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
US10524686B2 (en) * 2014-12-01 2020-01-07 The Regents Of The University Of California Diffusion reproducibility evaluation and measurement (DREAM)-MRI imaging methods
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TWI709403B (zh) 2014-12-05 2020-11-11 美商艾瑞岡醫藥公司 抗癌症組成物（二）
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CN109414422A (zh) 2016-05-23 2019-03-01 耶鲁大学 使用包含phy906提取物、黄芩提取物或来自这些提取物的化合物的联合疗法改善抗免疫检查点抑制剂的治疗指数
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CN107375276B (zh) * 2017-07-28 2021-03-16 广东工业大学 一种药物组合物及其应用
WO2019023651A2 (en) 2017-07-28 2019-01-31 Massachusetts Institute Of Technology MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR
WO2019023654A2 (en) * 2017-07-28 2019-01-31 Massachusetts Institute Of Technology DISCOVERING SMALL MOLECULES TARGETING THE ANDROGEN RECEPTOR AND USES THEREOF
CN111479560A (zh) * 2017-10-16 2020-07-31 阿拉贡药品公司 用于治疗非转移性去势难治性前列腺癌的抗雄激素
CN107722101A (zh) * 2017-11-03 2018-02-23 郑州大学 甾体吡啶类衍生物及其制备方法和应用
CN112687353B (zh) * 2019-01-29 2023-08-18 杭州纽安津生物科技有限公司 针对靶向药物egfr通路的酪氨酸激酶抑制剂的多肽疫苗组合及其设计方法
RU2731002C1 (ru) * 2019-10-22 2020-08-26 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения рака предстательной железы
KR102543618B1 (ko) * 2021-05-27 2023-06-13 사회복지법인 삼성생명공익재단 전립선암의 엔잘루타미드 저항성 예측용 신규 바이오마커 및 이의 용도
CN114113633B (zh) * 2021-12-27 2024-05-24 复旦大学 用于前列腺癌危险度诊断和疗效评估的分子指标、试剂盒

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