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MX2016001573A - Ensayos para timp2 con mejor rendimiento en muestras biológicas. - Google Patents

Ensayos para timp2 con mejor rendimiento en muestras biológicas.

Info

Publication number
MX2016001573A
MX2016001573A MX2016001573A MX2016001573A MX2016001573A MX 2016001573 A MX2016001573 A MX 2016001573A MX 2016001573 A MX2016001573 A MX 2016001573A MX 2016001573 A MX2016001573 A MX 2016001573A MX 2016001573 A MX2016001573 A MX 2016001573A
Authority
MX
Mexico
Prior art keywords
timp2
assays
biological samples
improved performance
immunoassays
Prior art date
Application number
MX2016001573A
Other languages
English (en)
Inventor
A Vijayendran Ravi
VENKATASUBBARAO Srivatsa
Original Assignee
Astute Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astute Medical Inc filed Critical Astute Medical Inc
Publication of MX2016001573A publication Critical patent/MX2016001573A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención proporciona inmunoensayos TIMP2 con mejor ejecución clínica, en particular, cuando se utiliza en la evaluación de lesiones renales. Los inmunoensayos se basa en la selección y el uso de anticuerpos y pares de anticuerpos que exhiben mejor ejecución del ensayo cuando se utilizan en especímenes clínicos complejos como fluidos biológicos y, en especial, cuando se utilizan en formatos e ensayos rápidos como dispositivos de flujo lateral.
MX2016001573A 2013-08-07 2014-08-07 Ensayos para timp2 con mejor rendimiento en muestras biológicas. MX2016001573A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361863073P 2013-08-07 2013-08-07
PCT/US2014/050195 WO2015021308A1 (en) 2013-08-07 2014-08-07 Assays for timp2 having improved performance in biological samples

Publications (1)

Publication Number Publication Date
MX2016001573A true MX2016001573A (es) 2016-09-07

Family

ID=52461941

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016001573A MX2016001573A (es) 2013-08-07 2014-08-07 Ensayos para timp2 con mejor rendimiento en muestras biológicas.

Country Status (12)

Country Link
US (2) US9879091B2 (es)
EP (2) EP3030582A4 (es)
JP (1) JP2016528236A (es)
KR (1) KR20160039682A (es)
CN (1) CN105531291A (es)
AU (1) AU2014305883A1 (es)
BR (1) BR112016002685A2 (es)
CA (1) CA2920521A1 (es)
EA (1) EA201690185A1 (es)
HK (1) HK1222180A1 (es)
MX (1) MX2016001573A (es)
WO (1) WO2015021308A1 (es)

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US10935548B2 (en) 2011-12-08 2021-03-02 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2
ES2926197T3 (es) 2013-01-17 2022-10-24 Astute Medical Inc Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
CN105917229B (zh) 2013-12-03 2019-04-26 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
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WO2018081578A1 (en) * 2016-10-28 2018-05-03 Astute Medical, Inc. Use of antibodies to timp-2 for the improvement of renal function
EP3577458A4 (en) 2017-02-06 2021-04-07 Astute Medical, Inc. METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PREDICTION OF RENAL LESION AND RENAL INSUFFICIENCY
EP3606554A4 (en) * 2017-04-05 2020-12-09 Astute Medical, Inc. ASSAYS FOR TIMP2 WITH IMPROVED EFFICIENCY IN BIOLOGICAL SAMPLES
US11435364B2 (en) 2018-05-24 2022-09-06 Renibus Therapeutics, Inc. Methods of treating patients at risk for renal injury and renal failure

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Also Published As

Publication number Publication date
US20180162953A1 (en) 2018-06-14
AU2014305883A1 (en) 2016-02-25
US10457744B2 (en) 2019-10-29
KR20160039682A (ko) 2016-04-11
EP3617234A1 (en) 2020-03-04
BR112016002685A2 (pt) 2018-01-30
HK1222180A1 (zh) 2017-06-23
EP3030582A4 (en) 2017-05-17
EA201690185A1 (ru) 2016-07-29
US9879091B2 (en) 2018-01-30
CN105531291A (zh) 2016-04-27
CA2920521A1 (en) 2015-02-12
EP3030582A1 (en) 2016-06-15
JP2016528236A (ja) 2016-09-15
WO2015021308A1 (en) 2015-02-12
US20160297893A1 (en) 2016-10-13

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