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MX2015016798A - Regulacion transcripcional guiada por acido ribonucleico. - Google Patents

Regulacion transcripcional guiada por acido ribonucleico.

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Publication number
MX2015016798A
MX2015016798A MX2015016798A MX2015016798A MX2015016798A MX 2015016798 A MX2015016798 A MX 2015016798A MX 2015016798 A MX2015016798 A MX 2015016798A MX 2015016798 A MX2015016798 A MX 2015016798A MX 2015016798 A MX2015016798 A MX 2015016798A
Authority
MX
Mexico
Prior art keywords
nucleic acid
rna
protein
cell
domain
Prior art date
Application number
MX2015016798A
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English (en)
Other versions
MX385330B (es
Inventor
George M Church
G Mali Prashant
M Esvelt Kevin
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52008736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015016798(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College filed Critical Harvard College
Publication of MX2015016798A publication Critical patent/MX2015016798A/es
Publication of MX385330B publication Critical patent/MX385330B/es

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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/3513—Protein; Peptide
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  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Lubricants (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se proveen métodos de modulación de la expresión de un ácido nucleico objetivo en una célula, que incluyen introducir en la célula un primer ácido nucleico ajeno que codifica uno o más ARN complementarios al ADN, en donde el ADN incluye el ácido nucleico objetivo, introducir en la célula un segundo ácido nucleico ajeno que codifica una proteína Cas9 nula de nucleasa que se une al ADN y es guiado por los uno o más ARN, introducir en la célula un tercer ácido nucleico ajeno que codifica una proteína o dominio regulador de transcripción, en donde son expresados los uno o más ARN, la proteína Cas9 nula de nucleasa y la proteína o dominio regulador de transcripción, en donde los uno o más ARN, la proteína Cas9 nula de nucleasa y la proteína o dominio regulador de transcripción se colocalizan en el ADN, y en donde la proteína o dominio regulador de transcripción regula la expresión del ácido nucleico objetivo.
MX2015016798A 2013-06-04 2014-06-04 Regulación transcripcional guiada por ácido ribonucleico. MX385330B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361830787P 2013-06-04 2013-06-04
PCT/US2014/040868 WO2014197568A2 (en) 2013-06-04 2014-06-04 Rna-guideded transcriptional regulation

Publications (2)

Publication Number Publication Date
MX2015016798A true MX2015016798A (es) 2016-10-26
MX385330B MX385330B (es) 2025-03-18

Family

ID=52008736

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015016798A MX385330B (es) 2013-06-04 2014-06-04 Regulación transcripcional guiada por ácido ribonucleico.
MX2021009672A MX2021009672A (es) 2013-06-04 2015-12-04 Regulacion transcripcional guiada por acido ribonucleico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021009672A MX2021009672A (es) 2013-06-04 2015-12-04 Regulacion transcripcional guiada por acido ribonucleico.

Country Status (15)

Country Link
US (2) US11981917B2 (es)
EP (4) EP3003392B1 (es)
JP (5) JP6621738B2 (es)
KR (3) KR102282990B1 (es)
CN (2) CN105451778B (es)
AU (4) AU2014274939B2 (es)
CA (2) CA3176690A1 (es)
ES (1) ES2930537T3 (es)
IL (3) IL284773B2 (es)
MX (2) MX385330B (es)
MY (3) MY197877A (es)
RU (2) RU2690935C2 (es)
SG (3) SG10201710030QA (es)
WO (1) WO2014197568A2 (es)
ZA (1) ZA201509025B (es)

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