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MX2015015182A - Células efectoras inmunitarias modificadas genéticamente con el receptor de antígenos quiméricos específico de cs1. - Google Patents

Células efectoras inmunitarias modificadas genéticamente con el receptor de antígenos quiméricos específico de cs1.

Info

Publication number
MX2015015182A
MX2015015182A MX2015015182A MX2015015182A MX2015015182A MX 2015015182 A MX2015015182 A MX 2015015182A MX 2015015182 A MX2015015182 A MX 2015015182A MX 2015015182 A MX2015015182 A MX 2015015182A MX 2015015182 A MX2015015182 A MX 2015015182A
Authority
MX
Mexico
Prior art keywords
immune effector
disclosed
effector cells
chimeric antigen
cells
Prior art date
Application number
MX2015015182A
Other languages
English (en)
Other versions
MX370173B (es
Inventor
Jianhua Yu
Craig Hofmeister
Jianhong Chu
Original Assignee
Ohio State Innovation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State Innovation Foundation filed Critical Ohio State Innovation Foundation
Publication of MX2015015182A publication Critical patent/MX2015015182A/es
Publication of MX370173B publication Critical patent/MX370173B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)

Abstract

En la presente se describen receptores de antígenos quiméricos (CAR) que pueden reconocer específicamente los antígenos asociados al tumor (TAA) en células de mieloma múltiple (MM). También se describen células efectoras inmunitarias, como linfocitos T o linfocitos citolíticos naturales (NK) que se modifican genéticamente para expresar estos CAR. Por lo tanto, también se describen métodos para proporcionar una inmunidad anti-tumoral en un sujeto con MM que implica transferencia adoptiva de las células efectoras inmunitarias descritas modificadas genéticamente para expresar los CAR descritos.
MX2015015182A 2013-05-03 2014-05-02 Células efectoras inmunitarias modificadas genéticamente con el receptor de antígenos quiméricos específico de cs1. MX370173B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361819141P 2013-05-03 2013-05-03
US201361876492P 2013-09-11 2013-09-11
PCT/US2014/036684 WO2014179759A1 (en) 2013-05-03 2014-05-02 Cs1-specific chimeric antigen receptor engineered immune effector cells

Publications (2)

Publication Number Publication Date
MX2015015182A true MX2015015182A (es) 2016-05-05
MX370173B MX370173B (es) 2019-12-04

Family

ID=51844005

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015182A MX370173B (es) 2013-05-03 2014-05-02 Células efectoras inmunitarias modificadas genéticamente con el receptor de antígenos quiméricos específico de cs1.

Country Status (15)

Country Link
US (3) US10358494B2 (es)
EP (2) EP2992020B1 (es)
JP (3) JP6856188B2 (es)
KR (1) KR102098985B1 (es)
CN (2) CN105377897A (es)
AU (2) AU2014259675B2 (es)
BR (1) BR112015027567B1 (es)
DK (1) DK2992020T3 (es)
ES (1) ES2777940T3 (es)
HU (1) HUE048312T2 (es)
IL (1) IL242315B (es)
MX (1) MX370173B (es)
PL (1) PL2992020T3 (es)
PT (1) PT2992020T (es)
WO (1) WO2014179759A1 (es)

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EP2992020A4 (en) 2016-12-28
EP2992020B1 (en) 2020-01-15
JP7221338B2 (ja) 2023-02-13
BR112015027567A2 (pt) 2017-12-05
US20200002418A1 (en) 2020-01-02
US20160075784A1 (en) 2016-03-17
AU2019203823A1 (en) 2019-06-20
PT2992020T (pt) 2020-02-28
IL242315B (en) 2020-07-30
US20170320941A1 (en) 2017-11-09
JP6856188B2 (ja) 2021-04-07
PL2992020T3 (pl) 2020-06-01
AU2019203823B2 (en) 2021-05-13
BR112015027567B1 (pt) 2024-02-20
EP3663320A1 (en) 2020-06-10
AU2014259675A1 (en) 2015-11-12
DK2992020T3 (da) 2020-02-10
KR20160003071A (ko) 2016-01-08
US10227409B2 (en) 2019-03-12
JP2019146579A (ja) 2019-09-05
US11845794B2 (en) 2023-12-19
JP2021177771A (ja) 2021-11-18
EP2992020A1 (en) 2016-03-09
HUE048312T2 (hu) 2020-07-28
AU2014259675B2 (en) 2019-05-02
WO2014179759A1 (en) 2014-11-06
US10358494B2 (en) 2019-07-23
KR102098985B1 (ko) 2020-04-09
MX370173B (es) 2019-12-04
ES2777940T3 (es) 2020-08-06
CN115028735A (zh) 2022-09-09
CN105377897A (zh) 2016-03-02
JP2016524598A (ja) 2016-08-18
CA2910666A1 (en) 2014-11-06
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