MX2015012783A - Administracion subcutanea de una desintegrina y metaloproteinasa con motivos tipo i de trombospondina 13 (adamts13). - Google Patents
Administracion subcutanea de una desintegrina y metaloproteinasa con motivos tipo i de trombospondina 13 (adamts13).Info
- Publication number
- MX2015012783A MX2015012783A MX2015012783A MX2015012783A MX2015012783A MX 2015012783 A MX2015012783 A MX 2015012783A MX 2015012783 A MX2015012783 A MX 2015012783A MX 2015012783 A MX2015012783 A MX 2015012783A MX 2015012783 A MX2015012783 A MX 2015012783A
- Authority
- MX
- Mexico
- Prior art keywords
- adamts13
- subcutaneous administration
- disintegrine
- metaloproteinase
- motives
- Prior art date
Links
- 238000007920 subcutaneous administration Methods 0.000 title abstract 2
- 102000002938 Thrombospondin Human genes 0.000 title 1
- 108060008245 Thrombospondin Proteins 0.000 title 1
- 102000043853 ADAMTS13 Human genes 0.000 abstract 3
- 108091005670 ADAMTS13 Proteins 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se relaciona con métodos de administración subcutánea de formulaciones de ADAMTS13 para tratar una enfermedad o afección asociada a la disfunción de vWF y ADAMTS13. Además, en la presente se proporcionan pruebas de la alta biodisponibilidad no esperada de las formulaciones de ADAMTS13 administradas por vía subcutánea.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794659P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/026747 WO2014151968A1 (en) | 2013-03-15 | 2014-03-13 | Subcutaneous administration of adamts13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015012783A true MX2015012783A (es) | 2016-04-28 |
| MX380485B MX380485B (es) | 2025-03-12 |
Family
ID=50549463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012783A MX380485B (es) | 2013-03-15 | 2014-03-13 | Composición que comprende desintegrina y metaloproteinasa con motivos tipo i de trombospondina 13 (adamts13) para administración subcutánea. |
| MX2021002513A MX2021002513A (es) | 2013-03-15 | 2015-09-14 | Composicion que comprende desintegrina y metaloproteinasa con motivos tipo i de trombospondina 13 (adamts13) para administracion subcutanea. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021002513A MX2021002513A (es) | 2013-03-15 | 2015-09-14 | Composicion que comprende desintegrina y metaloproteinasa con motivos tipo i de trombospondina 13 (adamts13) para administracion subcutanea. |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9611467B2 (es) |
| EP (2) | EP3960196A1 (es) |
| JP (4) | JP6484216B2 (es) |
| KR (5) | KR20160016756A (es) |
| CN (2) | CN114259558A (es) |
| AU (5) | AU2013203062C1 (es) |
| BR (1) | BR112015023542A8 (es) |
| CA (1) | CA2905058A1 (es) |
| DK (1) | DK2968483T3 (es) |
| EA (2) | EA034546B1 (es) |
| ES (1) | ES2906550T3 (es) |
| IL (3) | IL241305B (es) |
| MX (2) | MX380485B (es) |
| PL (1) | PL2968483T3 (es) |
| PT (1) | PT2968483T (es) |
| SG (3) | SG10201707074TA (es) |
| TW (4) | TW202313664A (es) |
| WO (1) | WO2014151968A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013203062C1 (en) * | 2013-03-15 | 2018-06-28 | Takeda Pharmaceutical Company Limited | Subcutaneous administration of adamts13 |
| GB201510870D0 (en) * | 2015-05-26 | 2015-08-05 | Baxalta Inc And Katholieke Universiteit Leuven And Baxalta Gmbh | Treatment of infarction |
| CN116159130B (zh) | 2016-08-04 | 2025-09-09 | 武田药品工业株式会社 | 使用adamts13治疗、改善和/或预防镰状细胞病、急性肺损伤和/或急性呼吸窘迫综合征中的血管阻塞危象 |
| WO2020214033A1 (en) * | 2019-04-17 | 2020-10-22 | Erasmus University Medical Center Rotterdam | Papain-like cysteine peptidase medicaments and uses thereof |
| EP4037704B1 (en) | 2019-10-04 | 2025-12-03 | The Children's Medical Center Corporation | Adamts13 treatment to enhance graft survival |
| US20230203469A1 (en) | 2020-04-02 | 2023-06-29 | Takeda Pharmaceutical Company Limited | Adamts13 variant, compositions, and uses thereof |
| EP4153215A1 (en) | 2020-05-22 | 2023-03-29 | Takeda Pharmaceutical Company Limited | Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease |
| KR20230038658A (ko) * | 2020-05-25 | 2023-03-21 | 산퀸 아이피 비.브이. | Adamts13 단백질 변형체 및 그것의 용도 |
| CA3201986A1 (en) * | 2020-11-18 | 2022-05-27 | Green Cross Corporation | Adamts13 variant having increased escaping rate or activity against autoantibody |
| GB202102208D0 (en) * | 2021-02-17 | 2021-03-31 | Univ Manchester | Adamts13 variant |
| KR20240112755A (ko) * | 2023-01-11 | 2024-07-19 | 주식회사 녹십자 | 혈전성 질환의 예방 또는 치료를 위한 신규한 액상 제형물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL113010A (en) | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| US6926894B2 (en) | 2000-11-22 | 2005-08-09 | Baxter Aktiengesellschaft | Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV |
| US7037658B2 (en) * | 2001-08-16 | 2006-05-02 | Regents Of University Of Michigan | Methods and compositions for detecting variant ADAMTS13 genes |
| US7763430B2 (en) | 2003-04-22 | 2010-07-27 | Baxter International Inc. | Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies |
| ES2382104T3 (es) * | 2005-06-17 | 2012-06-05 | Baxter International Inc. | Composiciones con actividad trombolítica que comprenden ADAMTS13 |
| JP2009539757A (ja) * | 2006-06-16 | 2009-11-19 | バクスター・インターナショナル・インコーポレイテッド | 血栓溶解活性を有するａｄａｍｔｓ１３含有組成物 |
| WO2009140140A1 (en) * | 2008-05-12 | 2009-11-19 | Immune Disease Institute | Von willebrand factor (vwf) inhibitors for treatment or prevention of infarction |
| WO2011020866A2 (en) * | 2009-08-20 | 2011-02-24 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| CN102573792B (zh) * | 2009-09-21 | 2014-10-15 | 巴克斯特国际公司 | 稳定化的液体和冻干的adamts13制剂 |
| PT3064508T (pt) * | 2010-07-08 | 2019-12-05 | Baxalta Inc | Método de produção de fvw recombinante de elevado peso molecular na cultura de células |
| AU2013203062C1 (en) * | 2013-03-15 | 2018-06-28 | Takeda Pharmaceutical Company Limited | Subcutaneous administration of adamts13 |
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2013
- 2013-04-09 AU AU2013203062A patent/AU2013203062C1/en active Active
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2014
- 2014-03-13 MX MX2015012783A patent/MX380485B/es unknown
- 2014-03-13 SG SG10201707074TA patent/SG10201707074TA/en unknown
- 2014-03-13 KR KR1020157028432A patent/KR20160016756A/ko not_active Ceased
- 2014-03-13 BR BR112015023542A patent/BR112015023542A8/pt not_active Application Discontinuation
- 2014-03-13 KR KR1020207010406A patent/KR102218489B1/ko active Active
- 2014-03-13 US US14/210,167 patent/US9611467B2/en active Active
- 2014-03-13 EP EP21203692.5A patent/EP3960196A1/en active Pending
- 2014-03-13 KR KR1020217004442A patent/KR102365936B1/ko active Active
- 2014-03-13 KR KR1020197005635A patent/KR102102087B1/ko active Active
- 2014-03-13 SG SG10202001227QA patent/SG10202001227QA/en unknown
- 2014-03-13 SG SG11201507271QA patent/SG11201507271QA/en unknown
- 2014-03-13 PT PT147194690T patent/PT2968483T/pt unknown
- 2014-03-13 JP JP2016502232A patent/JP6484216B2/ja active Active
- 2014-03-13 CN CN202111631652.1A patent/CN114259558A/zh active Pending
- 2014-03-13 PL PL14719469T patent/PL2968483T3/pl unknown
- 2014-03-13 EA EA201591758A patent/EA034546B1/ru not_active IP Right Cessation
- 2014-03-13 CN CN201480027202.3A patent/CN105407912A/zh active Pending
- 2014-03-13 EP EP14719469.0A patent/EP2968483B1/en active Active
- 2014-03-13 KR KR1020227005350A patent/KR102513872B1/ko active Active
- 2014-03-13 CA CA2905058A patent/CA2905058A1/en active Pending
- 2014-03-13 EA EA201992832A patent/EA201992832A1/ru unknown
- 2014-03-13 WO PCT/US2014/026747 patent/WO2014151968A1/en not_active Ceased
- 2014-03-13 DK DK14719469.0T patent/DK2968483T3/da active
- 2014-03-13 ES ES14719469T patent/ES2906550T3/es active Active
- 2014-03-14 TW TW111144983A patent/TW202313664A/zh unknown
- 2014-03-14 TW TW110108163A patent/TWI786563B/zh active
- 2014-03-14 TW TW103109832A patent/TWI690326B/zh active
- 2014-03-14 TW TW108133433A patent/TWI740207B/zh active
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2015
- 2015-09-08 IL IL241305A patent/IL241305B/en active IP Right Grant
- 2015-09-14 MX MX2021002513A patent/MX2021002513A/es unknown
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2016
- 2016-09-22 AU AU2016231547A patent/AU2016231547B2/en active Active
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2017
- 2017-02-22 US US15/439,154 patent/US10413600B2/en active Active
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2018
- 2018-05-24 AU AU2018203665A patent/AU2018203665B2/en active Active
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2019
- 2019-02-15 JP JP2019025097A patent/JP6998333B2/ja active Active
- 2019-09-11 US US16/567,048 patent/US11185575B2/en active Active
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2020
- 2020-03-17 IL IL273365A patent/IL273365B/en unknown
- 2020-04-23 AU AU2020202738A patent/AU2020202738B2/en active Active
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2021
- 2021-11-12 US US17/525,759 patent/US11779635B2/en active Active
- 2021-12-20 JP JP2021205839A patent/JP7238088B2/ja active Active
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2022
- 2022-02-09 IL IL290486A patent/IL290486B2/en unknown
- 2022-08-05 AU AU2022211908A patent/AU2022211908B2/en active Active
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2023
- 2023-03-01 JP JP2023030589A patent/JP2023071821A/ja active Pending
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