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MX2015009785A - Moduladores de receptores nmda de espiro-lactama y sus usos. - Google Patents

Moduladores de receptores nmda de espiro-lactama y sus usos.

Info

Publication number
MX2015009785A
MX2015009785A MX2015009785A MX2015009785A MX2015009785A MX 2015009785 A MX2015009785 A MX 2015009785A MX 2015009785 A MX2015009785 A MX 2015009785A MX 2015009785 A MX2015009785 A MX 2015009785A MX 2015009785 A MX2015009785 A MX 2015009785A
Authority
MX
Mexico
Prior art keywords
nmda receptor
spiro
receptor modulators
compounds
lactam nmda
Prior art date
Application number
MX2015009785A
Other languages
English (en)
Inventor
John A Lowe Iii
M Amin Khan
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50071824&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015009785(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of MX2015009785A publication Critical patent/MX2015009785A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se divulgan compuestos que tienen potencia mejorada para la modulación de la actividad de los receptores NMDA. Dichos compuestos se contemplan para uso en el tratamiento de afecciones tales como la depresión y trastornos relacionados. También se divulgan formulaciones disponibles oralmente y otras formas de administración de los compuestos farmacéuticamente aceptables, incluidas formulaciones intravenosas.
MX2015009785A 2013-01-29 2014-01-29 Moduladores de receptores nmda de espiro-lactama y sus usos. MX2015009785A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361757942P 2013-01-29 2013-01-29
PCT/US2014/013639 WO2014120800A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
MX2015009785A true MX2015009785A (es) 2016-04-04

Family

ID=50071824

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015009785A MX2015009785A (es) 2013-01-29 2014-01-29 Moduladores de receptores nmda de espiro-lactama y sus usos.

Country Status (16)

Country Link
US (2) US9708335B2 (es)
EP (1) EP2951185B1 (es)
JP (1) JP2016506962A (es)
KR (1) KR20150110784A (es)
CN (1) CN105308049A (es)
AU (1) AU2014212501A1 (es)
BR (1) BR112015018094A2 (es)
CA (1) CA2899191A1 (es)
EA (1) EA201591405A1 (es)
ES (1) ES2618421T3 (es)
IL (1) IL240164A0 (es)
MX (1) MX2015009785A (es)
PE (1) PE20151436A1 (es)
PH (1) PH12015501598A1 (es)
SG (1) SG11201505862TA (es)
WO (1) WO2014120800A1 (es)

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PE20151427A1 (es) 2013-01-29 2015-10-10 Naurex Inc Moduladores de receptores nmda de espiro-lactama y sus usos
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WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
JP2022536773A (ja) 2019-06-14 2022-08-18 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロピラジン及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用
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Also Published As

Publication number Publication date
AU2014212501A1 (en) 2015-07-30
SG11201505862TA (en) 2015-08-28
IL240164A0 (en) 2015-09-24
JP2016506962A (ja) 2016-03-07
EP2951185B1 (en) 2016-12-21
US20150368254A1 (en) 2015-12-24
WO2014120800A1 (en) 2014-08-07
US10316041B2 (en) 2019-06-11
KR20150110784A (ko) 2015-10-02
EP2951185A1 (en) 2015-12-09
CA2899191A1 (en) 2014-08-07
US20180127430A1 (en) 2018-05-10
US9708335B2 (en) 2017-07-18
ES2618421T3 (es) 2017-06-21
PE20151436A1 (es) 2015-10-10
BR112015018094A2 (pt) 2017-07-18
EA201591405A1 (ru) 2017-05-31
CN105308049A (zh) 2016-02-03
PH12015501598A1 (en) 2015-10-19

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