MX2015005286A - Procedimiento para la preparación de derivados del ácido biliar. - Google Patents
Procedimiento para la preparación de derivados del ácido biliar.Info
- Publication number
- MX2015005286A MX2015005286A MX2015005286A MX2015005286A MX2015005286A MX 2015005286 A MX2015005286 A MX 2015005286A MX 2015005286 A MX2015005286 A MX 2015005286A MX 2015005286 A MX2015005286 A MX 2015005286A MX 2015005286 A MX2015005286 A MX 2015005286A
- Authority
- MX
- Mexico
- Prior art keywords
- acid derivatives
- bile acid
- preparing bile
- preparing
- solvate
- Prior art date
Links
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a procedimientos para preparar compuestos de fórmula I: (ver Fórmula) o una sal o salvato farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718966P | 2012-10-26 | 2012-10-26 | |
| PCT/US2013/066917 WO2014066819A1 (en) | 2012-10-26 | 2013-10-25 | Process for preparing bile acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015005286A true MX2015005286A (es) | 2015-10-29 |
| MX361653B MX361653B (es) | 2018-12-13 |
Family
ID=50545344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015005286A MX361653B (es) | 2012-10-26 | 2013-10-25 | Procedimiento para la preparación de derivados del ácido biliar. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9777038B2 (es) |
| EP (1) | EP2912013B1 (es) |
| JP (1) | JP6272888B2 (es) |
| KR (1) | KR102068381B1 (es) |
| CN (2) | CN105102425B (es) |
| AU (1) | AU2013334122B2 (es) |
| BR (1) | BR112015009395A2 (es) |
| CA (1) | CA2889592A1 (es) |
| CY (1) | CY1119731T1 (es) |
| DK (1) | DK2912013T3 (es) |
| ES (1) | ES2655034T3 (es) |
| HK (1) | HK1253301A1 (es) |
| HU (1) | HUE036887T2 (es) |
| IL (1) | IL238454B (es) |
| MX (1) | MX361653B (es) |
| NO (1) | NO2968302T3 (es) |
| NZ (2) | NZ707389A (es) |
| PL (1) | PL2912013T3 (es) |
| PT (1) | PT2912013T (es) |
| SG (1) | SG11201503247UA (es) |
| SM (1) | SMT201700602T1 (es) |
| WO (1) | WO2014066819A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105102425B (zh) | 2012-10-26 | 2018-04-10 | 英特塞普特医药品公司 | 制备胆汁酸衍生物的方法 |
| AU2015265893B2 (en) | 2014-05-29 | 2020-11-12 | Bar Pharmaceuticals S.R.L. | Cholane derivatives for use in the treatment and/or prevention of FXR and TGR5/GPBAR1 mediated diseases |
| ES2759725T3 (es) | 2014-11-19 | 2020-05-12 | Nzp Uk Ltd | Esteroides 6-alquil-7-hidroxi-4-en-3-ona como intermediarios para la producción de moduladores de FXR esteroideo |
| JP6735748B2 (ja) | 2014-11-19 | 2020-08-05 | エヌゼットピー ユーケー リミテッド | ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−３，７−ジオン−ステロイド |
| CN107207558B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-6,7-二酮类固醇 |
| PL3221332T3 (pl) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr |
| CN104672290B (zh) * | 2015-01-05 | 2017-06-06 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途 |
| EP4035665A1 (en) | 2015-02-06 | 2022-08-03 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions for combination therapy |
| AU2016325619A1 (en) | 2015-09-24 | 2018-04-12 | Intercept Pharmaceuticals, Inc. | Methods and intermediates for the preparation bile acid derivatives |
| US10604545B2 (en) * | 2015-11-06 | 2020-03-31 | Intercept Pharmaceuticals, Inc. | Methods for the preparation of obeticholic acid and derivatives thereof |
| WO2017142895A1 (en) * | 2016-02-15 | 2017-08-24 | Regents Of The University Of Minnesota | Compositions and methods for treating clostridium associated diseases |
| EP3442946A4 (en) | 2016-04-13 | 2019-12-04 | Intercept Pharmaceuticals, Inc. | METHOD FOR THE TREATMENT OF CANCER |
| TW201738254A (zh) * | 2016-04-19 | 2017-11-01 | 英特賽普醫藥品公司 | 奧貝膽酸及其衍生物之製備方法 |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| EP3518937A4 (en) * | 2016-09-30 | 2020-04-29 | Intercept Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF A BILIARY ACID DERIVATIVE |
| BR112020001362A2 (pt) | 2017-07-24 | 2020-08-11 | Intercept Pharmaceuticals, Inc. | derivados de ácido biliar isotopicamente marcados |
| JP7308811B2 (ja) * | 2017-07-26 | 2023-07-14 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | ステロイド系誘導体ｆｘｒアゴニストの製造方法 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| CN114144185A (zh) | 2019-05-30 | 2022-03-04 | 英特塞普特医药品公司 | 用于治疗胆汁淤积性肝病的包含fxr激动剂和贝特类的药物组合物 |
| AU2020363377A1 (en) | 2019-10-07 | 2022-04-21 | Kallyope, Inc. | GPR119 agonists |
| AU2021228729A1 (en) | 2020-02-28 | 2022-09-22 | Kallyope, Inc. | GPR40 agonists |
| UY39222A (es) | 2020-05-19 | 2021-11-30 | Kallyope Inc | Activadores de la ampk |
| AU2021297323A1 (en) | 2020-06-26 | 2023-02-16 | Kallyope, Inc. | AMPK activators |
| US20230331766A1 (en) | 2020-09-18 | 2023-10-19 | Seoul National University R&Db Foundation | Method for mass-producing sodium taurodeoxycholate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216015A (en) | 1991-02-05 | 1993-06-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having hypocholesterolemic properties |
| DK1392714T3 (da) | 2001-03-12 | 2006-01-09 | Intercept Pharmaceuticals Inc | Steroider som agonister for FXR |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| EP2040713B1 (en) * | 2006-06-27 | 2014-06-18 | Intercept Pharmaceuticals Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| US9943614B2 (en) | 2008-06-17 | 2018-04-17 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| CN102164940B (zh) * | 2008-07-30 | 2015-08-19 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
| CA2744135C (en) * | 2008-11-19 | 2017-07-04 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| CN105102425B (zh) | 2012-10-26 | 2018-04-10 | 英特塞普特医药品公司 | 制备胆汁酸衍生物的方法 |
-
2013
- 2013-10-25 CN CN201380068062.XA patent/CN105102425B/zh not_active Expired - Fee Related
- 2013-10-25 JP JP2015539862A patent/JP6272888B2/ja not_active Expired - Fee Related
- 2013-10-25 EP EP13849263.2A patent/EP2912013B1/en not_active Not-in-force
- 2013-10-25 PL PL13849263T patent/PL2912013T3/pl unknown
- 2013-10-25 CA CA2889592A patent/CA2889592A1/en not_active Abandoned
- 2013-10-25 CN CN201810282054.XA patent/CN108250264A/zh active Pending
- 2013-10-25 NZ NZ707389A patent/NZ707389A/en not_active IP Right Cessation
- 2013-10-25 KR KR1020157012805A patent/KR102068381B1/ko not_active Expired - Fee Related
- 2013-10-25 SM SM20170602T patent/SMT201700602T1/it unknown
- 2013-10-25 WO PCT/US2013/066917 patent/WO2014066819A1/en not_active Ceased
- 2013-10-25 MX MX2015005286A patent/MX361653B/es active IP Right Grant
- 2013-10-25 HU HUE13849263A patent/HUE036887T2/hu unknown
- 2013-10-25 NZ NZ745013A patent/NZ745013A/en not_active IP Right Cessation
- 2013-10-25 PT PT138492632T patent/PT2912013T/pt unknown
- 2013-10-25 ES ES13849263.2T patent/ES2655034T3/es active Active
- 2013-10-25 US US14/438,323 patent/US9777038B2/en active Active
- 2013-10-25 BR BR112015009395A patent/BR112015009395A2/pt not_active Application Discontinuation
- 2013-10-25 AU AU2013334122A patent/AU2013334122B2/en not_active Ceased
- 2013-10-25 DK DK13849263.2T patent/DK2912013T3/en active
- 2013-10-25 SG SG11201503247UA patent/SG11201503247UA/en unknown
-
2014
- 2014-03-14 NO NO14725812A patent/NO2968302T3/no unknown
-
2015
- 2015-04-26 IL IL238454A patent/IL238454B/en active IP Right Grant
-
2016
- 2016-02-24 HK HK18112593.6A patent/HK1253301A1/zh unknown
-
2017
- 2017-08-21 US US15/681,609 patent/US10202414B2/en not_active Expired - Fee Related
-
2018
- 2018-01-03 CY CY20181100003T patent/CY1119731T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |