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MX2015004119A - Uso del p3 de proteinas de fusion de bacteriofago como agentes de union amiloides. - Google Patents

Uso del p3 de proteinas de fusion de bacteriofago como agentes de union amiloides.

Info

Publication number
MX2015004119A
MX2015004119A MX2015004119A MX2015004119A MX2015004119A MX 2015004119 A MX2015004119 A MX 2015004119A MX 2015004119 A MX2015004119 A MX 2015004119A MX 2015004119 A MX2015004119 A MX 2015004119A MX 2015004119 A MX2015004119 A MX 2015004119A
Authority
MX
Mexico
Prior art keywords
fusion proteins
binding agents
amyloid binding
amyloid
bacteriophage
Prior art date
Application number
MX2015004119A
Other languages
English (en)
Other versions
MX358755B (es
Inventor
Rajaraman Krishnan
Richard Fisher
Original Assignee
Neurophage Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurophage Pharmaceuticals Inc filed Critical Neurophage Pharmaceuticals Inc
Publication of MX2015004119A publication Critical patent/MX2015004119A/es
Publication of MX358755B publication Critical patent/MX358755B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/00022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/00033Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/14011Details ssDNA Bacteriophages
    • C12N2795/14111Inoviridae
    • C12N2795/14122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/14011Details ssDNA Bacteriophages
    • C12N2795/14111Inoviridae
    • C12N2795/14133Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Wood Science & Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se relaciona con agentes y composiciones farmacéuticas para reducir la formación de amiloide y/o para promover la desagregación de proteínas amiloide. Las composiciones también se pueden usar para detectar amiloide.
MX2015004119A 2012-10-02 2013-10-01 Uso del p3 de proteinas de fusion de bacteriofago como agentes de union amiloides. MX358755B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261708709P 2012-10-02 2012-10-02
US201261730316P 2012-11-27 2012-11-27
US201361801349P 2013-03-15 2013-03-15
US201361828105P 2013-05-28 2013-05-28
PCT/US2013/062862 WO2014055515A1 (en) 2012-10-02 2013-10-01 Use of p3 of bacteriophage fusion proteins as amyloid binding agents

Publications (2)

Publication Number Publication Date
MX2015004119A true MX2015004119A (es) 2015-10-26
MX358755B MX358755B (es) 2018-09-03

Family

ID=49354958

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004119A MX358755B (es) 2012-10-02 2013-10-01 Uso del p3 de proteinas de fusion de bacteriofago como agentes de union amiloides.

Country Status (25)

Country Link
US (3) US9688728B2 (es)
EP (1) EP2906235B1 (es)
JP (1) JP6283366B2 (es)
KR (1) KR102101258B1 (es)
CN (1) CN104870008B (es)
AR (1) AR092879A1 (es)
AU (1) AU2013327472B2 (es)
BR (1) BR112015007424A2 (es)
CY (1) CY1120132T1 (es)
DK (1) DK2906235T3 (es)
EA (1) EA033666B1 (es)
ES (1) ES2641373T3 (es)
HR (1) HRP20171413T1 (es)
HU (1) HUE036893T2 (es)
IL (1) IL238021B (es)
LT (1) LT2906235T (es)
MX (1) MX358755B (es)
NZ (1) NZ706838A (es)
PL (1) PL2906235T3 (es)
PT (1) PT2906235T (es)
SI (1) SI2906235T1 (es)
SM (1) SMT201700473T1 (es)
TW (1) TWI613212B (es)
WO (1) WO2014055515A1 (es)
ZA (1) ZA201502940B (es)

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LT2906235T (lt) 2012-10-02 2017-10-25 Proclara Biosciences, Inc. Bakteriofago sulietų baltymų p3, kaip amiloido rišamųjų agentų, naudojimas
US9988444B2 (en) 2013-05-28 2018-06-05 Proclara Biosciences, Inc. Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity
KR20170085132A (ko) 2014-12-03 2017-07-21 프로클라라 바이오사이언시즈, 인크. 글리코실화 신호가 결핍된 변형된 박테리오파지 g3p 아미노산 서열을 포함하는 폴리펩티드
TW202523853A (zh) * 2015-03-27 2025-06-16 美商再生元醫藥公司 偵測生物污染物之組成物及方法
EP3532497B1 (en) 2016-10-26 2024-07-24 The Board of Trustees of the Leland Stanford Junior University Modified immunoglobulin hinge regions to reduce hemagglutination
ES2960493T3 (es) 2018-06-15 2024-03-05 Amyl Therapeutics Motivo de interacción amiloide general (GAIM)
CN115605483A (zh) 2020-07-06 2023-01-13 莫尔根生物有限公司(Kr) 三环双内酯化合物、其生产方法及用途
US20250325558A1 (en) * 2022-05-25 2025-10-23 Alan Jerome Fowler Modulation of bace1 as a therapy for spinocerebellar ataxia
CN115820567B (zh) * 2022-07-26 2025-06-06 成都盛世君联生物技术有限公司 耐高温辅助噬菌体tr-3及其应用
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KR20170085132A (ko) 2014-12-03 2017-07-21 프로클라라 바이오사이언시즈, 인크. 글리코실화 신호가 결핍된 변형된 박테리오파지 g3p 아미노산 서열을 포함하는 폴리펩티드

Also Published As

Publication number Publication date
KR102101258B1 (ko) 2020-04-16
AU2013327472A1 (en) 2015-05-21
IL238021B (en) 2019-06-30
BR112015007424A2 (pt) 2021-04-20
AR092879A1 (es) 2015-05-06
EA033666B1 (ru) 2019-11-14
US20170305975A1 (en) 2017-10-26
HRP20171413T1 (hr) 2017-12-15
KR20150063544A (ko) 2015-06-09
US10526377B2 (en) 2020-01-07
EP2906235A1 (en) 2015-08-19
DK2906235T3 (en) 2017-09-25
US9688728B2 (en) 2017-06-27
EP2906235B1 (en) 2017-07-19
LT2906235T (lt) 2017-10-25
SI2906235T1 (sl) 2017-12-29
ES2641373T3 (es) 2017-11-08
US20180354994A1 (en) 2018-12-13
WO2014055515A1 (en) 2014-04-10
CY1120132T1 (el) 2018-12-12
AU2013327472B2 (en) 2017-10-26
MX358755B (es) 2018-09-03
HK1213775A1 (en) 2016-07-15
IL238021A0 (en) 2015-05-31
CN104870008B (zh) 2019-10-01
AU2013327472A2 (en) 2015-06-04
US10208090B2 (en) 2019-02-19
CN104870008A (zh) 2015-08-26
PL2906235T3 (pl) 2017-12-29
JP6283366B2 (ja) 2018-02-21
US20150376239A1 (en) 2015-12-31
TWI613212B (zh) 2018-02-01
HUE036893T2 (hu) 2018-08-28
EA201590690A1 (ru) 2016-04-29
JP2015532290A (ja) 2015-11-09
TW201418279A (zh) 2014-05-16
SMT201700473T1 (it) 2017-11-15
NZ706838A (en) 2017-06-30
PT2906235T (pt) 2017-09-28
ZA201502940B (en) 2017-11-29

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