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MX2015001374A - Compuestos. - Google Patents

Compuestos.

Info

Publication number
MX2015001374A
MX2015001374A MX2015001374A MX2015001374A MX2015001374A MX 2015001374 A MX2015001374 A MX 2015001374A MX 2015001374 A MX2015001374 A MX 2015001374A MX 2015001374 A MX2015001374 A MX 2015001374A MX 2015001374 A MX2015001374 A MX 2015001374A
Authority
MX
Mexico
Prior art keywords
compounds
optionally substituted
hydrogen atom
methods
substituted alkyl
Prior art date
Application number
MX2015001374A
Other languages
English (en)
Other versions
MX364940B (es
Inventor
Jon Erik Braenden
Jo Klaveness
Nils Olav Nilsen
Aslak Godal
Colin Barry Charnock
Original Assignee
Photocure Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure Asa filed Critical Photocure Asa
Publication of MX2015001374A publication Critical patent/MX2015001374A/es
Publication of MX364940B publication Critical patent/MX364940B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a nuevos derivados del ácido 5-aminolevulínico (5-ALA) y su uso como agentes fotosensibilizantes. En particular, se relaciona a compuestos de fórmula I general y su sal farmacéuticamente aceptable , a los métodos para la preparación de tales compuestos y su uso médico y cosmético, por ejemplo en métodos de diagnóstico y terapia fotodinámica: (ver fórmula) En donde R1 representa un átomo de hidrógeno o un grupo alquilo o cicloalquilo opcionalmente sustituido; R2, cada uno del cual puede ser el mismo o diferente, representa un átomo de hidrógeno o un grupo de alquilo opcionalmente sustituido; y x es un grupo vinculante.
MX2015001374A 2012-08-03 2013-08-02 Compuestos. MX364940B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12179277 2012-08-03
EP12197305 2012-12-14
PCT/EP2013/066317 WO2014020164A1 (en) 2012-08-03 2013-08-02 Compounds

Publications (2)

Publication Number Publication Date
MX2015001374A true MX2015001374A (es) 2015-09-07
MX364940B MX364940B (es) 2019-05-15

Family

ID=48948407

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001374A MX364940B (es) 2012-08-03 2013-08-02 Compuestos.

Country Status (18)

Country Link
US (1) US9249086B2 (es)
EP (1) EP2880012B1 (es)
JP (1) JP6280117B2 (es)
KR (1) KR102180174B1 (es)
CN (1) CN104661994B (es)
AU (1) AU2013298525B2 (es)
BR (1) BR112015002390B1 (es)
CA (1) CA2880422C (es)
CL (1) CL2015000233A1 (es)
ES (1) ES2908080T3 (es)
IL (1) IL236965B (es)
IN (1) IN2015DN00837A (es)
MX (1) MX364940B (es)
NZ (1) NZ629914A (es)
RU (1) RU2635563C2 (es)
SG (1) SG11201500805VA (es)
WO (1) WO2014020164A1 (es)
ZA (1) ZA201500778B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6595484B2 (ja) 2013-12-20 2019-10-23 ガルデルマ・リサーチ・アンド・デヴェロップメント 光損傷皮膚のパルス光力学的処置
US10457627B2 (en) * 2015-09-23 2019-10-29 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
MX385912B (es) * 2015-12-17 2025-03-18 Photocure Asa Metodo de terapia fotodinamica (pdt) para el cancer de vejiga
GB201522309D0 (en) * 2015-12-17 2016-02-03 Photocure Asa Use
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN112010772A (zh) * 2016-01-26 2020-12-01 赵鸣 5-氨基酮戊酸及其衍生物的盐化合物和应用
ES2965514T3 (es) * 2017-06-21 2024-04-15 Photocure Asa Procedimiento de preparación de una composición farmacéutica líquida y dispositivo para su uso en dicho procedimiento
IL285384B2 (en) 2019-02-13 2024-11-01 Alpheus Medical Inc Non-invasive sonodynamic therapy
EP3976107A4 (en) 2019-05-29 2023-10-11 Sonalasense, Inc. Sonosensitization
EP4192404A4 (en) 2020-08-07 2024-04-03 Alpheus Medical, Inc. Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
WO2024184417A1 (en) 2023-03-07 2024-09-12 Photocure Asa Therapy for bladder cancer

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07188133A (ja) 1993-12-27 1995-07-25 Asahi Chem Ind Co Ltd δ−アミノレブリン酸またはその同族体の製造法
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
HU225148B1 (en) 1995-03-10 2006-07-28 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy or diagnosis, products and kits comprising thereof and method of in vitro diagnosis by their using
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
JPH1112197A (ja) 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk 悪性腫瘍診断剤及び治療剤
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
DE10202487A1 (de) 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermales Applikationssystem für Aminolävulinsäure-Derivate
DE10312659A1 (de) 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
ES2355978T3 (es) * 2004-03-30 2011-04-01 Cosmo Oil Co., Ltd. Sal de fosfato de ácido 5-aminolevulinico, proceso para producir la misma y uso de la misma.
JP4417865B2 (ja) 2004-03-30 2010-02-17 コスモ石油株式会社 ５−アミノレブリン酸リン酸塩、その製造方法及びその用途
JP4719483B2 (ja) 2004-03-30 2011-07-06 コスモ石油株式会社 ５−アミノレブリン酸スルホン酸塩の製造方法
GB0424833D0 (en) * 2004-11-10 2004-12-15 Photocure Asa Method
JP5404995B2 (ja) 2006-08-10 2014-02-05 コスモ石油株式会社 植物のポリフェノール増量剤
JP5039389B2 (ja) 2007-02-02 2012-10-03 コスモ石油株式会社 ホップのアルファ酸又はホップオイル含量向上剤
ES2550243T3 (es) 2007-03-30 2015-11-05 Cosmo Ala Co., Ltd. Agente para mejorar la resistencia a los álcalis de una planta y método para mejorar la resistencia a los álcalis de una planta
JP4705616B2 (ja) 2007-07-20 2011-06-22 コスモ石油株式会社 植物における金属成分の吸収向上剤
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
JP2011506425A (ja) * 2007-12-14 2011-03-03 フォトデルマ エスアー 治療的及び美容的方法に有用な新規化合物
DK2272538T3 (da) 2008-04-22 2020-10-26 Sbi Pharmaceuticals Co Ltd Fremgangsmåde til påvisning af blærecancer
JP5276894B2 (ja) 2008-05-13 2013-08-28 コスモ石油株式会社 イネの健苗育成向上剤
JP5323821B2 (ja) 2008-05-13 2013-10-23 コスモ石油株式会社 芝草の品質向上剤
JP5323539B2 (ja) 2009-03-11 2013-10-23 コスモ石油株式会社 農作物の収穫部位の収量向上剤

Also Published As

Publication number Publication date
AU2013298525A1 (en) 2015-03-05
SG11201500805VA (en) 2015-02-27
BR112015002390A2 (pt) 2017-07-04
EP2880012B1 (en) 2021-12-15
US20150191419A1 (en) 2015-07-09
ES2908080T3 (es) 2022-04-27
BR112015002390B1 (pt) 2020-03-24
CN104661994A (zh) 2015-05-27
BR112015002390A8 (pt) 2019-07-30
KR20150039208A (ko) 2015-04-09
ZA201500778B (en) 2016-04-28
RU2015104830A (ru) 2016-09-27
US9249086B2 (en) 2016-02-02
CN104661994B (zh) 2017-08-08
CA2880422C (en) 2021-02-09
MX364940B (es) 2019-05-15
HK1211283A1 (en) 2016-05-20
IL236965B (en) 2019-03-31
CA2880422A1 (en) 2014-02-06
JP2015528814A (ja) 2015-10-01
IN2015DN00837A (es) 2015-06-12
AU2013298525B2 (en) 2017-12-14
JP6280117B2 (ja) 2018-02-14
WO2014020164A1 (en) 2014-02-06
KR102180174B1 (ko) 2020-11-19
CL2015000233A1 (es) 2015-04-24
RU2635563C2 (ru) 2017-11-14
EP2880012A1 (en) 2015-06-10
NZ629914A (en) 2017-02-24

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