MX2015000554A - Encapsulación de fases inmisibles en biomateriales de fibroína de seda. - Google Patents
Encapsulación de fases inmisibles en biomateriales de fibroína de seda.Info
- Publication number
- MX2015000554A MX2015000554A MX2015000554A MX2015000554A MX2015000554A MX 2015000554 A MX2015000554 A MX 2015000554A MX 2015000554 A MX2015000554 A MX 2015000554A MX 2015000554 A MX2015000554 A MX 2015000554A MX 2015000554 A MX2015000554 A MX 2015000554A
- Authority
- MX
- Mexico
- Prior art keywords
- encapsulation
- silk fibroin
- immiscible phases
- biomaterials
- fibroin biomaterials
- Prior art date
Links
- 238000005538 encapsulation Methods 0.000 title abstract 2
- 108010022355 Fibroins Proteins 0.000 title 1
- 239000012620 biological material Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 150000002634 lipophilic molecules Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L35/00—Foods or foodstuffs not provided for in groups A23L5/00 - A23L33/00; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Las modalidades de los diversos aspectos descritos en la presente se refieren a composiciones y métodos para la encapsulación y/o estabilización de compuestos de aceite, lípidos, hidrófobos y/o lipófilos en un material a base de seda. Las composiciones descritas en este documento pueden usarse en diversas aplicaciones, por ejemplo aplicaciones farmacéutica, cosmética, alimenticia, de diagnóstico y de ingeniería de tejidos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261671336P | 2012-07-13 | 2012-07-13 | |
| US201361791185P | 2013-03-15 | 2013-03-15 | |
| PCT/US2013/050529 WO2014012105A1 (en) | 2012-07-13 | 2013-07-15 | Encapsulation of immiscible phases in silk fibroin biomaterials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015000554A true MX2015000554A (es) | 2015-09-28 |
Family
ID=49916590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015000554A MX2015000554A (es) | 2012-07-13 | 2013-07-15 | Encapsulación de fases inmisibles en biomateriales de fibroína de seda. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150202304A1 (es) |
| EP (1) | EP2872115A4 (es) |
| JP (2) | JP2015530361A (es) |
| CN (1) | CN104684540A (es) |
| BR (1) | BR112015000739A2 (es) |
| MX (1) | MX2015000554A (es) |
| WO (1) | WO2014012105A1 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2513838C1 (ru) * | 2013-02-21 | 2014-04-20 | Общество с ограниченной ответственностью "ДЖИ-Групп" | Гистоэквивалент-биопластический материал |
| US11802270B2 (en) | 2014-08-07 | 2023-10-31 | Tufts University | Microphysiologic methods and compositions |
| GB201415681D0 (en) * | 2014-09-04 | 2014-10-22 | Cambridge Entpr Ltd And President And Fellows Of Harvard College | Protien Capsules |
| GB201415679D0 (en) * | 2014-09-04 | 2014-10-22 | Cambridge Entpr Ltd And University Of Sheffield The | Silk Protien Structures |
| SG11201704494SA (en) | 2014-12-02 | 2017-06-29 | Silk Therapeutics Inc | Silk performance apparel and products and methods of preparing the same |
| CN114923837B (zh) * | 2015-02-09 | 2025-09-19 | 弹弓生物科学公司 | 具有可调光学性质的水凝胶颗粒以及使用其的方法 |
| CN104984359A (zh) * | 2015-05-28 | 2015-10-21 | 杭州优玛达生物科技有限公司 | 生物膜、具有生物膜性的闭合结构或细胞区室作为疫苗载体或免疫调节剂的应用 |
| EP3322434B1 (en) | 2015-07-14 | 2024-12-11 | Evolved by Nature, Inc. | Silk performance apparel and products and methods of preparing the same |
| EP3144058A1 (en) * | 2015-09-16 | 2017-03-22 | Calyxia | Method for preparing microcapsules by double emulsion |
| US20190031843A1 (en) * | 2016-01-29 | 2019-01-31 | Riken | Molded Article, Production Method for Same, and Method for Improving Toughness of Molded Article |
| WO2017131195A1 (ja) * | 2016-01-29 | 2017-08-03 | 国立研究開発法人理化学研究所 | 成形体及びその製造方法、並びに成形体の結晶化度を向上させる方法 |
| CN109310632A (zh) * | 2016-04-12 | 2019-02-05 | 封装技术私人有限公司 | 用于递送生物活性剂的可注射组合物 |
| CN108778354A (zh) * | 2016-04-13 | 2018-11-09 | 印度医学研究理事会 | 用于骨-软组织固定应用的纳米工程化的生物可吸收聚合物复合材料 |
| WO2017219305A1 (en) * | 2016-06-23 | 2017-12-28 | The University Of Hong Kong | Cavity-microfibers, methods and apparatuses for the fabrication of microfibers, threads, and filaments |
| CA3064953A1 (en) * | 2017-05-26 | 2018-11-29 | Dakota Biotech, Llc | Stabilized compositions for the controlled delivery of probiotics and methods of production thereof |
| US11331019B2 (en) | 2017-08-07 | 2022-05-17 | The Research Foundation For The State University Of New York | Nanoparticle sensor having a nanofibrous membrane scaffold |
| WO2019067745A1 (en) | 2017-09-27 | 2019-04-04 | Silk, Inc. | SILK-COATED FABRICS, PRODUCTS AND PREPARATION METHODS THEREFOR |
| WO2019089567A1 (en) | 2017-10-30 | 2019-05-09 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
| CN108479650B (zh) * | 2018-03-26 | 2021-02-23 | 上海应用技术大学 | 一种桂花香精-丝素蛋白微胶囊及制备方法 |
| CN108192731B (zh) * | 2018-03-26 | 2021-06-11 | 上海应用技术大学 | 一种甜橙香精-丝素蛋白微胶囊及制备方法 |
| TWI691531B (zh) * | 2019-02-11 | 2020-04-21 | 南臺學校財團法人南臺科技大學 | 蠶絲蛋白膜的製造方法 |
| EP3975841A1 (en) | 2019-05-30 | 2022-04-06 | Massachusetts Institute of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
| US10945953B1 (en) | 2019-09-12 | 2021-03-16 | Nulixir Inc. | Controlled release core-shell particles and suspensions including the same |
| CN113493936B (zh) * | 2020-03-19 | 2023-02-28 | 立肯诺(上海)新材料科技有限公司 | 一种含珍珠中药的防红疹再生纤维素纤维及其制备方法 |
| EP4147049A1 (en) | 2020-05-04 | 2023-03-15 | Slingshot Biosciences, Inc. | Compositions and methods for passive optical barcoding for multiplexed assays |
| WO2022220827A1 (en) * | 2021-04-14 | 2022-10-20 | Cambridge Crops, Inc. | Silk packaging applications |
| CN114949181B (zh) * | 2021-10-13 | 2025-05-09 | 拓腾华宝(苏州)生物技术有限公司 | 一种含有表皮生长因子微胶囊的修复乳及其制备方法 |
| AU2022376541A1 (en) | 2021-10-29 | 2024-04-18 | Slingshot Biosciences, Inc. | Hydrogel particles as feeder cells and as synthetic antigen presenting cells |
| EP4441081A4 (en) * | 2021-11-29 | 2025-10-15 | Massachusetts Inst Technology | ADJUSTABLE STRUCTURE OF BIODEGRADABLE SILK-BASED MICROCAPSULES FOR DELIVERY OF SOLUBLE AND INSOLUBLE PAYLOAD |
| CN114099646B (zh) * | 2021-12-01 | 2024-02-06 | 江苏奥普莱医疗用品有限公司 | 一种可重复使用的具有缓释胶原蛋白的脂质体混悬液及其制备方法 |
| CN114351449B (zh) * | 2022-01-25 | 2023-09-15 | 江苏丰裕纺织科技有限公司 | 一种防霉布料及其制备方法 |
| EP4489900A1 (en) | 2022-03-08 | 2025-01-15 | Xampla Limited | Biodegradable microcapsules and method for their preparation |
| CN114656680B (zh) * | 2022-03-31 | 2023-03-21 | 安徽工程大学 | 一种超弹性丝素蛋白微-纳米杂化纤维气凝胶及其制备方法与应用 |
| AU2023265684A1 (en) | 2022-05-05 | 2024-11-21 | Slingshot Biosciences, Inc. | Engineered particles as red blood cell mimics and compositions containing same for hematology |
| WO2023235885A1 (en) | 2022-06-02 | 2023-12-07 | Slingshot Biosciences, Inc. | Apoptotic cell mimic |
| CN115193496B (zh) * | 2022-07-18 | 2024-02-27 | 南昌大学 | 一种微流道装置和该装置制备的高载油微胶囊及其方法 |
| EP4608872A2 (en) | 2022-10-26 | 2025-09-03 | Slingshot Biosciences, Inc. | Size-tunable synthetic particles with tunable optical properties and methods for using the same for immune cell activation |
| US12461007B2 (en) | 2023-08-29 | 2025-11-04 | Slingshot Biosciences, Inc. | CD34 stem cell mimics |
| WO2025054426A1 (en) * | 2023-09-06 | 2025-03-13 | Trustees Of Tufts College | Edible transferable holographic image films and methods |
| TWI852789B (zh) * | 2023-10-05 | 2024-08-11 | 國泰醫療財團法人國泰綜合醫院 | 血型檢驗產品、複合纖維不織布用途、體外血型檢驗方法和體外輸血相容檢驗方法 |
| WO2025193717A1 (en) * | 2024-03-11 | 2025-09-18 | Trustees Of Tufts College | Sound mediated assembly of biopolymers |
| WO2025193920A1 (en) * | 2024-03-13 | 2025-09-18 | Trustees Of Tufts College | Protein-based nanocarriers and related methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9606188D0 (en) * | 1996-03-23 | 1996-05-29 | Danbiosyst Uk | Pollysaccharide microspheres for the pulmonary delivery of drugs |
| US20050147690A1 (en) * | 1998-09-25 | 2005-07-07 | Masters David B. | Biocompatible protein particles, particle devices and methods thereof |
| FR2808703B1 (fr) * | 2000-05-09 | 2002-08-02 | Centre Nat Rech Scient | Procede de preparation d'une emulsion double monodisperse |
| EP1275370A1 (en) * | 2001-07-13 | 2003-01-15 | Johnson and Johnson GmbH | Products comprising a sheet and a lipid and aqueous phase |
| ES2294606T3 (es) * | 2005-08-01 | 2008-04-01 | Technische Universitat Munchen | Procedimiento para la produccion de nano y microcapsulas de proteinas de seda de araña. |
| US20100028451A1 (en) * | 2006-09-26 | 2010-02-04 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
| US20080292693A1 (en) * | 2007-05-21 | 2008-11-27 | Sones Scott F | Composition and method for treating digestive system disorders |
| PT2211876E (pt) * | 2007-05-29 | 2015-01-14 | Tufts College | Método de gelificação de fibroína de seda utilizando sonicação |
| JP5730317B2 (ja) * | 2009-09-29 | 2015-06-10 | タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ | 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法 |
| WO2014093270A1 (en) * | 2012-12-10 | 2014-06-19 | Virginia Commonwealth University | Tropism modified cancer terminator virus (ad.5/3 ctv;ad.5/3-ctv-m7) |
-
2013
- 2013-07-15 WO PCT/US2013/050529 patent/WO2014012105A1/en not_active Ceased
- 2013-07-15 MX MX2015000554A patent/MX2015000554A/es unknown
- 2013-07-15 BR BR112015000739A patent/BR112015000739A2/pt not_active Application Discontinuation
- 2013-07-15 JP JP2015521883A patent/JP2015530361A/ja active Pending
- 2013-07-15 CN CN201380047460.3A patent/CN104684540A/zh active Pending
- 2013-07-15 US US14/414,218 patent/US20150202304A1/en not_active Abandoned
- 2013-07-15 EP EP13817106.1A patent/EP2872115A4/en not_active Withdrawn
-
2018
- 2018-08-20 JP JP2018153961A patent/JP2018184474A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2872115A4 (en) | 2016-04-06 |
| JP2018184474A (ja) | 2018-11-22 |
| JP2015530361A (ja) | 2015-10-15 |
| EP2872115A1 (en) | 2015-05-20 |
| US20150202304A1 (en) | 2015-07-23 |
| CN104684540A (zh) | 2015-06-03 |
| WO2014012105A1 (en) | 2014-01-16 |
| BR112015000739A2 (pt) | 2017-06-27 |
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