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MX2014013089A - Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih). - Google Patents

Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih).

Info

Publication number
MX2014013089A
MX2014013089A MX2014013089A MX2014013089A MX2014013089A MX 2014013089 A MX2014013089 A MX 2014013089A MX 2014013089 A MX2014013089 A MX 2014013089A MX 2014013089 A MX2014013089 A MX 2014013089A MX 2014013089 A MX2014013089 A MX 2014013089A
Authority
MX
Mexico
Prior art keywords
triterpenoids
inhibitory activity
bicyclic amines
hiv maturation
compounds
Prior art date
Application number
MX2014013089A
Other languages
English (en)
Other versions
MX354914B (es
Inventor
Nicholas A Meanwell
Yan Chen
Zheng Liu
Alicia Regueiro-Ren
Jie Chen
Jacob Swidorski
Sing-Yuen Sit
Ny Sin
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2014013089A publication Critical patent/MX2014013089A/es
Publication of MX354914B publication Critical patent/MX354914B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se indican compuestos que tienen propiedades farmacológicas y que afectan el aspecto biológico, sus composiciones farmacéuticas y métodos de uso. En particular, las aminas bicíclicas C-17 de triterpenoides que tienen una actividad antiviral única se proveen como inhibidores de la maduración del VIH, como se representa mediante los compuestos de las Fórmulas I, II y III: (ver Fórmula) Estos compuestos son útiles para el tratamiento del VIH y del SIDA.
MX2014013089A 2012-05-07 2013-05-03 Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih). MX354914B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261643483P 2012-05-07 2012-05-07
US13/799,479 US8889854B2 (en) 2012-05-07 2013-03-13 C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
PCT/US2013/039389 WO2013169578A1 (en) 2012-05-07 2013-05-03 C-17 bicyclic amines of triterpenoids with hiv maturation inhibitory activity

Publications (2)

Publication Number Publication Date
MX2014013089A true MX2014013089A (es) 2014-12-08
MX354914B MX354914B (es) 2018-03-26

Family

ID=49513043

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013089A MX354914B (es) 2012-05-07 2013-05-03 Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih).

Country Status (17)

Country Link
US (1) US8889854B2 (es)
EP (1) EP2847208B1 (es)
JP (1) JP6212545B2 (es)
KR (1) KR20150013157A (es)
CN (1) CN104540844B (es)
AR (1) AR090955A1 (es)
AU (1) AU2013259894B2 (es)
BR (1) BR112014027669A2 (es)
CA (1) CA2872891C (es)
EA (1) EA027133B1 (es)
ES (1) ES2652510T3 (es)
IL (1) IL235465A (es)
MX (1) MX354914B (es)
PT (1) PT2847208T (es)
SG (1) SG11201407189XA (es)
TW (1) TWI574973B (es)
WO (1) WO2013169578A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
WO2014123889A1 (en) 2013-02-06 2014-08-14 Bristol-Myers Squibb Company C-19 modified triterpenoids with hiv maturation inhibitory activity
AU2014218754B2 (en) 2013-02-25 2017-04-20 VIIV Healthcare UK (No.5) Limited C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of HIV
DK3129392T3 (da) 2014-04-11 2020-10-19 Viiv Healthcare Uk No 4 Ltd Triterpenoider med hiv-modningsinhiberende aktivitet, substitueret i position 3 af en ikke-aromatisk ring som bærer en haloalkylsubstituent
US9920090B2 (en) 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
JP2018512433A (ja) 2015-04-14 2018-05-17 ヴィーブ ヘルスケア ユーケー（ナンバー４）リミテッド Ｈｉｖ成熟阻害剤の製造方法
CA2993758A1 (en) 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
CA2993753A1 (en) 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
EP3353158A1 (en) 2015-09-24 2018-08-01 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds with hiv maturation inhibitory activity
JP2019502728A (ja) 2016-01-20 2019-01-31 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ成熟阻害活性を有するルパンのアミン誘導体
AR107512A1 (es) * 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
JP7670482B2 (ja) 2017-09-13 2025-04-30 エミオン インコーポレイテッド ウルソール酸モルホリン塩及びジエタノールアミン塩
JP7436385B2 (ja) 2018-04-24 2024-02-21 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Ｈｉｖ成熟阻害活性を有する化合物
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
EP3924361B1 (en) 2019-02-11 2023-09-06 Hetero Labs Limited Novel triterpene derivatives as hiv inhibitors

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TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
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CA2801487C (en) 2010-06-04 2017-12-05 Bristol-Myers Squibb Company Modified c-3 betulinic acid derivatives as hiv maturation inhibitors
SI2576586T1 (sl) * 2010-06-04 2015-11-30 Bristol-Myers Squibb Company C-28 amidi derivatov modificirane c-3 betulinske kisline kot inhibitorji zorenja hiv
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JP6100786B2 (ja) 2011-09-21 2017-03-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ウイルス活性を有する新規ベツリン酸誘導体
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity

Also Published As

Publication number Publication date
US8889854B2 (en) 2014-11-18
CA2872891C (en) 2018-10-23
BR112014027669A2 (pt) 2017-06-27
PT2847208T (pt) 2017-12-14
JP2015516422A (ja) 2015-06-11
EA027133B1 (ru) 2017-06-30
EP2847208B1 (en) 2017-10-04
JP6212545B2 (ja) 2017-10-11
EA201492016A1 (ru) 2015-02-27
AU2013259894B2 (en) 2017-07-13
TWI574973B (zh) 2017-03-21
CN104540844B (zh) 2016-12-07
AR090955A1 (es) 2014-12-17
CA2872891A1 (en) 2013-11-14
KR20150013157A (ko) 2015-02-04
EP2847208A1 (en) 2015-03-18
MX354914B (es) 2018-03-26
IL235465A (en) 2015-11-30
TW201350499A (zh) 2013-12-16
ES2652510T3 (es) 2018-02-02
SG11201407189XA (en) 2014-12-30
CN104540844A (zh) 2015-04-22
WO2013169578A1 (en) 2013-11-14
AU2013259894A1 (en) 2015-01-15
US20130296554A1 (en) 2013-11-07

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Owner name: VIIV HEALTHCARE UK (NO. 5) LIMITED

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