MX2014006210A - Derivados de 2-(fenil o pirid-3-il)aminopirimidina como moduladores de proteina cinasa 2 de repeticion rica en leucina (lrrk2) para el tratamiento de la enfermedad de parkinson. - Google Patents
Derivados de 2-(fenil o pirid-3-il)aminopirimidina como moduladores de proteina cinasa 2 de repeticion rica en leucina (lrrk2) para el tratamiento de la enfermedad de parkinson.Info
- Publication number
- MX2014006210A MX2014006210A MX2014006210A MX2014006210A MX2014006210A MX 2014006210 A MX2014006210 A MX 2014006210A MX 2014006210 A MX2014006210 A MX 2014006210A MX 2014006210 A MX2014006210 A MX 2014006210A MX 2014006210 A MX2014006210 A MX 2014006210A
- Authority
- MX
- Mexico
- Prior art keywords
- parkinson
- disease
- treatment
- pyrid
- phenyl
- Prior art date
Links
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 150000005005 aminopyrimidines Chemical class 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000009784 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Human genes 0.000 abstract 1
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de la fórmula (I), o sales de los mismos farmacéuticamente aceptables, en donde m, n, X, R1, R2, R3, R4 y R5 son como se definen en la presente. También se describen métodos para elaborar los compuestos y usar los compuestos para el tratamiento de enfermedades asociadas con el receptor LRRK2, tal como la enfermedad de Parkinson.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564755P | 2011-11-29 | 2011-11-29 | |
| PCT/EP2012/073768 WO2013079495A1 (en) | 2011-11-29 | 2012-11-28 | 2-(phenyl or pyrid-3-yl) aminopyrimidine derivatives as kinase lrrk2 modulators for the treatment of parkinson's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014006210A true MX2014006210A (es) | 2014-08-08 |
| MX348920B MX348920B (es) | 2017-07-04 |
Family
ID=47263348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014006210A MX348920B (es) | 2011-11-29 | 2012-11-28 | Derivados de 2-(fenil o pirid-3-il)aminopirimidina como moduladores de proteina cinasa 2 de repeticion rica en leucina (lrrk2) para el tratamiento de la enfermedad de parkinson. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8791130B2 (es) |
| EP (2) | EP2785711B1 (es) |
| JP (1) | JP6180426B2 (es) |
| KR (1) | KR102025451B1 (es) |
| CN (2) | CN106243090A (es) |
| BR (1) | BR112014009717B1 (es) |
| CA (1) | CA2850705C (es) |
| CY (1) | CY1118135T1 (es) |
| DK (1) | DK2785711T3 (es) |
| ES (1) | ES2592802T3 (es) |
| HR (1) | HRP20161396T1 (es) |
| HU (1) | HUE030694T2 (es) |
| LT (1) | LT2785711T (es) |
| MX (1) | MX348920B (es) |
| PL (1) | PL2785711T3 (es) |
| PT (1) | PT2785711T (es) |
| RS (1) | RS55370B1 (es) |
| RU (1) | RU2647849C2 (es) |
| SI (1) | SI2785711T1 (es) |
| WO (1) | WO2013079495A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013011600B1 (pt) * | 2010-11-10 | 2022-01-11 | Genentech, Inc | Derivados de pirazol aminopirimidina, seu uso e composição que os compreende |
| CA2850594C (en) * | 2011-11-29 | 2020-03-10 | F. Hoffmann-La Roche Ag | Aminopyrimidine derivatives as lrrk2 modulators |
| AR089182A1 (es) * | 2011-11-29 | 2014-08-06 | Hoffmann La Roche | Derivados de aminopirimidina como moduladores de lrrk2 |
| US20140228384A1 (en) * | 2011-11-29 | 2014-08-14 | Genentech, Inc. | Assays and biomarkers for lrrk2 |
| WO2013164323A1 (en) * | 2012-05-03 | 2013-11-07 | F. Hoffmann-La Roche Ag | Pyrazole aminopyrimidine derivatives as lrrk2 modulators for use in the treatment of parkinson's disease |
| WO2017156493A1 (en) | 2016-03-11 | 2017-09-14 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| WO2014134772A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| EP2968331B1 (en) | 2013-03-14 | 2020-07-01 | Icahn School of Medicine at Mount Sinai | Pyrimidine compounds as kinase inhibitors |
| WO2015069752A1 (en) * | 2013-11-05 | 2015-05-14 | The Regents Of The University Of California | Acetylcholine binding protein ligands, cooperative nachr modulators and methods for making and using |
| US10058559B2 (en) | 2014-05-15 | 2018-08-28 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Treatment or prevention of an intestinal disease or disorder |
| EP3204374B1 (en) * | 2014-10-08 | 2019-04-03 | UCB Biopharma SPRL | Isoindoline derivatives |
| EP3778604B1 (en) * | 2015-02-13 | 2026-01-07 | Dana-Farber Cancer Institute, Inc. | Lrrk2 inhibitors and methods of making and using the same |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| PE20190395A1 (es) | 2016-06-16 | 2019-03-13 | Denali Therapeutics Inc | Pirimidin-2-ilamino-1h-pirazoles como inhibidores de lrrk2 para el uso en el tratamiento de trastornos neurodegenerativos |
| MX2020005332A (es) | 2017-11-21 | 2021-01-08 | Denali Therapeutics Inc | Polimorfos y formas solidas de un compuesto de pirimidinilamino-pirazol y metodos de produccion. |
| BR112020012611A2 (pt) | 2017-12-20 | 2020-12-08 | Denali Therapeutics Inc. | Processo para a preparação de compostos pirimidinil-4-aminopirazol |
| HUE064465T2 (hu) | 2019-05-10 | 2024-04-28 | Deciphera Pharmaceuticals Llc | Heteroarilaminopirimidin amid autophagia inhibitorok és azok felhasználási eljárásai |
| SMT202300469T1 (it) | 2019-05-10 | 2024-01-10 | Deciphera Pharmaceuticals Llc | Inibitori dell'autofagia a base di fenilamminopirimidinammidi, e metodi di loro utilizzo |
| AU2020297422B2 (en) | 2019-06-17 | 2024-03-21 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| KR102252879B1 (ko) * | 2019-11-15 | 2021-05-17 | 성균관대학교산학협력단 | 혈장 내 aimp2를 이용한 파킨슨 질환의 진단 방법, 이를 위한 조성물 및 이를 포함하는 키트 |
| WO2021143729A1 (zh) * | 2020-01-15 | 2021-07-22 | 中国科学院上海药物研究所 | 多靶点抑制作用化合物、组合物、功能分子及其应用 |
| US20240254103A9 (en) | 2020-03-23 | 2024-08-01 | Whan In Pharmaceutical Co., Ltd. | Novel pyrimidine derivative, and composition for preventing or treating neurodegenerative diseases and cancer, comprising same |
| KR102342803B1 (ko) | 2020-03-23 | 2021-12-24 | 환인제약 주식회사 | 신규한 피리미딘 유도체 및 이를 포함하는 신경퇴행성 질환 및 암의 예방 또는 치료용 조성물 |
| WO2022084210A1 (en) | 2020-10-20 | 2022-04-28 | F. Hoffmann-La Roche Ag | Combination therapy of pd-1 axis binding antagonists and lrrk2 inhitibors |
| AU2023371948A1 (en) | 2022-11-03 | 2025-05-15 | Denali Therapeutics Inc. | Solid and co-crystal forms of a pyrimidine triazole compound |
| WO2024112746A1 (en) | 2022-11-22 | 2024-05-30 | Denali Therapeutics Inc. | Processes and intermediates for the preparation of a pyrimidine aminopyrazole compound |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS94703A (sr) * | 2001-05-29 | 2007-02-05 | Schering Aktiengesellschaft, | Cdk-inhibirajući pirimidini, njihovo dobijanje i primena kao sredstva za lečenje |
| CA2463989C (en) * | 2001-10-17 | 2012-01-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof |
| EA200500721A1 (ru) * | 2002-11-28 | 2005-12-29 | Шеринг Акциенгезельшафт | Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| WO2007149789A2 (en) | 2006-06-22 | 2007-12-27 | Applera Corporation | Conversion of target specific amplification to universal sequencing |
| ES2428716T3 (es) * | 2008-02-22 | 2013-11-11 | F. Hoffmann-La Roche Ag | Moduladores de beta-amiloide |
| WO2009122180A1 (en) * | 2008-04-02 | 2009-10-08 | Medical Research Council | Pyrimidine derivatives capable of inhibiting one or more kinases |
| WO2009127642A2 (en) * | 2008-04-15 | 2009-10-22 | Cellzome Limited | Use of lrrk2 inhibitors for neurodegenerative diseases |
| JP2012197231A (ja) * | 2009-08-06 | 2012-10-18 | Oncotherapy Science Ltd | Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体 |
| JP5752691B2 (ja) | 2009-09-29 | 2015-07-22 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 新規化合物 |
| JP5713367B2 (ja) * | 2010-06-04 | 2015-05-07 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｌｒｒｋ２モジュレーターとしてのアミノピリミジン誘導体 |
| BR112013011600B1 (pt) * | 2010-11-10 | 2022-01-11 | Genentech, Inc | Derivados de pirazol aminopirimidina, seu uso e composição que os compreende |
| KR102002198B1 (ko) * | 2011-11-29 | 2019-07-19 | 제넨테크, 인크. | Lrrk2 조절제로서의 아미노피리미딘 유도체 |
| CA2850594C (en) * | 2011-11-29 | 2020-03-10 | F. Hoffmann-La Roche Ag | Aminopyrimidine derivatives as lrrk2 modulators |
| AR089182A1 (es) * | 2011-11-29 | 2014-08-06 | Hoffmann La Roche | Derivados de aminopirimidina como moduladores de lrrk2 |
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2012
- 2012-11-28 LT LTEP12794308.2T patent/LT2785711T/lt unknown
- 2012-11-28 HR HRP20161396TT patent/HRP20161396T1/hr unknown
- 2012-11-28 HU HUE12794308A patent/HUE030694T2/en unknown
- 2012-11-28 CN CN201610618072.1A patent/CN106243090A/zh active Pending
- 2012-11-28 RU RU2014124639A patent/RU2647849C2/ru active
- 2012-11-28 EP EP12794308.2A patent/EP2785711B1/en active Active
- 2012-11-28 PT PT127943082T patent/PT2785711T/pt unknown
- 2012-11-28 JP JP2014543867A patent/JP6180426B2/ja active Active
- 2012-11-28 RS RS20160925A patent/RS55370B1/sr unknown
- 2012-11-28 ES ES12794308.2T patent/ES2592802T3/es active Active
- 2012-11-28 US US13/687,421 patent/US8791130B2/en active Active
- 2012-11-28 PL PL12794308T patent/PL2785711T3/pl unknown
- 2012-11-28 KR KR1020147017591A patent/KR102025451B1/ko active Active
- 2012-11-28 CN CN201280058780.4A patent/CN103958503B/zh active Active
- 2012-11-28 BR BR112014009717-8A patent/BR112014009717B1/pt active IP Right Grant
- 2012-11-28 DK DK12794308.2T patent/DK2785711T3/en active
- 2012-11-28 SI SI201230747A patent/SI2785711T1/sl unknown
- 2012-11-28 WO PCT/EP2012/073768 patent/WO2013079495A1/en not_active Ceased
- 2012-11-28 CA CA2850705A patent/CA2850705C/en active Active
- 2012-11-28 MX MX2014006210A patent/MX348920B/es active IP Right Grant
- 2012-11-28 EP EP16179983.8A patent/EP3121174A1/en not_active Withdrawn
-
2016
- 2016-10-05 CY CY20161100995T patent/CY1118135T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS55370B1 (sr) | 2017-03-31 |
| BR112014009717B1 (pt) | 2022-06-14 |
| US8791130B2 (en) | 2014-07-29 |
| JP2014533737A (ja) | 2014-12-15 |
| ES2592802T3 (es) | 2016-12-01 |
| CA2850705C (en) | 2020-03-10 |
| CN103958503B (zh) | 2016-09-28 |
| SI2785711T1 (sl) | 2016-12-30 |
| KR102025451B1 (ko) | 2019-09-25 |
| US20130158057A1 (en) | 2013-06-20 |
| PT2785711T (pt) | 2016-09-30 |
| DK2785711T3 (en) | 2016-09-05 |
| CY1118135T1 (el) | 2017-06-28 |
| LT2785711T (lt) | 2016-10-25 |
| HRP20161396T1 (hr) | 2016-12-02 |
| JP6180426B2 (ja) | 2017-08-16 |
| EP2785711B1 (en) | 2016-08-03 |
| CN106243090A (zh) | 2016-12-21 |
| HUE030694T2 (en) | 2017-06-28 |
| CN103958503A (zh) | 2014-07-30 |
| EP3121174A1 (en) | 2017-01-25 |
| BR112014009717A8 (pt) | 2018-01-16 |
| PL2785711T3 (pl) | 2017-01-31 |
| RU2647849C2 (ru) | 2018-03-21 |
| RU2014124639A (ru) | 2016-01-27 |
| WO2013079495A1 (en) | 2013-06-06 |
| BR112014009717A2 (pt) | 2017-04-18 |
| KR20140094649A (ko) | 2014-07-30 |
| EP2785711A1 (en) | 2014-10-08 |
| CA2850705A1 (en) | 2013-06-06 |
| MX348920B (es) | 2017-07-04 |
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