MX2014005710A - Un metodo de cribado de farmaco y usos del mismo. - Google Patents
Un metodo de cribado de farmaco y usos del mismo.Info
- Publication number
- MX2014005710A MX2014005710A MX2014005710A MX2014005710A MX2014005710A MX 2014005710 A MX2014005710 A MX 2014005710A MX 2014005710 A MX2014005710 A MX 2014005710A MX 2014005710 A MX2014005710 A MX 2014005710A MX 2014005710 A MX2014005710 A MX 2014005710A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- pharmacomap
- predicting
- screening method
- drug screening
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000007877 drug screening Methods 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 4
- 230000007012 clinical effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940000406 drug candidate Drugs 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/82—Translation products from oncogenes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen en la presente los métodos para el cribado de fármacos en un animal no humano usando la tecnología de alta resolución que conduce a la generación de mapas farmacológicos. Además se describen en la presente los métodos para predecir el beneficio terapéutico y/o la toxicidad de los compuestos candidatos del fármaco. En las modalidades específicas, se proporcionan en la presente los métodos para predecir los efectos clínicos de un fármaco de prueba con base en la comparación del mapa farmacológico del fármaco de prueba con uno o más fármacos de referencia con los resultados clínicos conocidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558877P | 2011-11-11 | 2011-11-11 | |
| PCT/US2012/064440 WO2013071099A1 (en) | 2011-11-11 | 2012-11-09 | A drug screening method and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014005710A true MX2014005710A (es) | 2015-03-09 |
Family
ID=48290605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014005710A MX2014005710A (es) | 2011-11-11 | 2012-11-09 | Un metodo de cribado de farmaco y usos del mismo. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140297199A1 (es) |
| EP (1) | EP2777074A4 (es) |
| JP (1) | JP2015507470A (es) |
| CN (1) | CN104040719A (es) |
| CA (1) | CA2854469A1 (es) |
| IN (1) | IN2014MN01101A (es) |
| MX (1) | MX2014005710A (es) |
| WO (1) | WO2013071099A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8503825B2 (en) | 2004-05-06 | 2013-08-06 | Christopher L. Kavanau | Method and system for aligning and classifying images |
| JP6483681B2 (ja) * | 2013-07-29 | 2019-03-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 刺激を動的に変化させるリアルタイムフィードバックシステム制御技術プラットホーム |
| US10788403B2 (en) | 2015-03-11 | 2020-09-29 | Tissuevision, Inc. | Systems and methods for serial staining and imaging |
| CN104850864A (zh) * | 2015-06-01 | 2015-08-19 | 深圳英智源智能系统有限公司 | 一种基于卷积神经网络的非监督图像识别方法 |
| EP3510500A4 (en) | 2016-09-12 | 2020-05-20 | Cornell University | COMPUTING SYSTEMS AND METHODS FOR IMPROVING THE ACCURACY OF MEDICINAL TOXICITY PREDICTIONS |
| JP7197477B2 (ja) * | 2016-11-18 | 2022-12-27 | ティシュヴィジョン、インコーポレーテッド | 自動化された組織切片の捕捉、指標付けおよび保管システム |
| US10303961B1 (en) * | 2017-04-13 | 2019-05-28 | Zoox, Inc. | Object detection and passenger notification |
| CN106990077A (zh) * | 2017-06-15 | 2017-07-28 | 福建师范大学 | 一种基于多光子显微与微流控芯片技术的高通量筛选系统 |
| EP3451190B1 (en) | 2017-09-04 | 2020-02-26 | Sap Se | Model-based analysis in a relational database |
| CN108766587B (zh) * | 2018-05-11 | 2022-05-03 | 北京诺道认知医学科技有限公司 | 一种基于指定药物构建给药数据库的方法及装置 |
| JP6559850B1 (ja) * | 2018-07-27 | 2019-08-14 | Ｋａｒｙｄｏ ＴｈｅｒａｐｅｕｔｉＸ株式会社 | ヒトにおける被験物質の作用を予測するための人工知能モデル |
| US11486950B2 (en) * | 2018-08-01 | 2022-11-01 | General Electric Company | Systems and methods for automated graphical prescription with deep neural networks |
| JP6558786B1 (ja) * | 2018-09-28 | 2019-08-14 | 学校法人東北工業大学 | 標的の特性の予測を行うための方法、コンピュータシステム、プログラム |
| EP3644228B1 (en) * | 2018-10-23 | 2024-08-14 | The Chinese University Of Hong Kong | Method and apparatus for segmenting cellular image |
| US20220113288A1 (en) * | 2019-02-12 | 2022-04-14 | Neurovis Inc. | Neurotransmitter-based brain mapping method and use of brain map |
| KR102307479B1 (ko) * | 2019-02-12 | 2021-09-30 | 단국대학교 천안캠퍼스 산학협력단 | 신경전달물질 기반의 뇌 지도 작성 방법 및 뇌 지도를 이용하는 용도 |
| CN109709129A (zh) * | 2019-02-13 | 2019-05-03 | 李秀利 | 一种高通量筛选药物的磁共振成像方法 |
| US11808760B1 (en) * | 2019-02-14 | 2023-11-07 | Curi Bio, Inc. | System and methods for in vitro structural toxicity testing |
| CN113678143A (zh) * | 2019-02-20 | 2021-11-19 | 蓝岩治疗有限公司 | 使用人工智能在大图像数据集中检测目标细胞 |
| CN110178757B (zh) * | 2019-04-19 | 2021-08-27 | 广东医科大学附属医院 | 一种斑马鱼脑创伤模型及其制备方法和应用 |
| EP4014156A1 (en) * | 2019-08-13 | 2022-06-22 | Sanofi | Predicting patient responses to a chemical substance |
| JPWO2021075574A1 (es) * | 2019-10-17 | 2021-04-22 | ||
| CN110850070B (zh) * | 2019-11-22 | 2021-06-01 | 北京大学 | 一种基于荧光标记转基因动物模型评价化学物质生殖发育毒性的方法 |
| CN111061729B (zh) * | 2019-11-29 | 2021-04-16 | 武汉大学 | 顾及粒度的矢量瓦片组织方法 |
| US12241830B2 (en) * | 2019-12-06 | 2025-03-04 | Broad Institute, Inc. | Living biosensors |
| CN111062346A (zh) * | 2019-12-21 | 2020-04-24 | 电子科技大学 | 一种白细胞自动定位检测及分类识别系统及方法 |
| US11461216B1 (en) | 2020-05-18 | 2022-10-04 | Vignet Incorporated | Monitoring and improving data collection using digital health technology |
| US11605038B1 (en) | 2020-05-18 | 2023-03-14 | Vignet Incorporated | Selecting digital health technology to achieve data collection compliance in clinical trials |
| CN111657861B (zh) * | 2020-06-04 | 2022-02-25 | 浙江大学 | 基于双光子显微镜技术的溶栓药效评价方法 |
| US20230374590A1 (en) * | 2021-09-14 | 2023-11-23 | Massachusetts Institute Of Technology | Methods and reagent for diagnosing bipolar disorder |
| US12310625B2 (en) | 2023-06-26 | 2025-05-27 | Conceivable Life Sciences Inc. | Autonomous insemination in an intelligent automated in vitro fertilization and intracytoplasmic sperm injection platform |
| WO2024168475A1 (zh) * | 2023-02-13 | 2024-08-22 | 深圳先进技术研究院 | 一种有效率比较不同药物对抗焦虑效果的评价方法和装置 |
| CN116369275B (zh) * | 2023-03-01 | 2025-03-28 | 山东师范大学 | 一种特异性操作生长抑素神经元动物模型的构建方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7998704B2 (en) * | 2002-03-07 | 2011-08-16 | Carnegie Mellon University | Methods for magnetic resonance imaging |
| US8952213B2 (en) * | 2002-04-26 | 2015-02-10 | The Board Of Trustees Of The Leland Stanford Junior University | Neuronal activation in a transgenic model |
| US7372985B2 (en) * | 2003-08-15 | 2008-05-13 | Massachusetts Institute Of Technology | Systems and methods for volumetric tissue scanning microscopy |
| CA2652562C (en) * | 2006-05-17 | 2015-05-12 | Cellumen, Inc. | Method for automated tissue analysis |
-
2012
- 2012-11-09 WO PCT/US2012/064440 patent/WO2013071099A1/en not_active Ceased
- 2012-11-09 MX MX2014005710A patent/MX2014005710A/es unknown
- 2012-11-09 EP EP12847222.2A patent/EP2777074A4/en not_active Withdrawn
- 2012-11-09 JP JP2014541325A patent/JP2015507470A/ja active Pending
- 2012-11-09 CA CA2854469A patent/CA2854469A1/en not_active Abandoned
- 2012-11-09 CN CN201280066634.6A patent/CN104040719A/zh active Pending
- 2012-11-09 US US14/356,975 patent/US20140297199A1/en not_active Abandoned
-
2014
- 2014-06-04 IN IN1101MUN2014 patent/IN2014MN01101A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2854469A1 (en) | 2013-05-16 |
| EP2777074A4 (en) | 2015-08-19 |
| JP2015507470A (ja) | 2015-03-12 |
| CN104040719A (zh) | 2014-09-10 |
| US20140297199A1 (en) | 2014-10-02 |
| EP2777074A1 (en) | 2014-09-17 |
| IN2014MN01101A (es) | 2015-07-03 |
| WO2013071099A1 (en) | 2013-05-16 |
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