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MX2014005570A - El uso de anticuerpos anti factor estimulante de la colonia de macrofagos para tratar trastornos inflamatorios. - Google Patents

El uso de anticuerpos anti factor estimulante de la colonia de macrofagos para tratar trastornos inflamatorios.

Info

Publication number
MX2014005570A
MX2014005570A MX2014005570A MX2014005570A MX2014005570A MX 2014005570 A MX2014005570 A MX 2014005570A MX 2014005570 A MX2014005570 A MX 2014005570A MX 2014005570 A MX2014005570 A MX 2014005570A MX 2014005570 A MX2014005570 A MX 2014005570A
Authority
MX
Mexico
Prior art keywords
antibodies
csf
relates
methods
human anti
Prior art date
Application number
MX2014005570A
Other languages
English (en)
Inventor
Heath M Guay
Martin Hagen
Deborah Ann Young
Kyriaki Dunussi-Joannopoulos
Sudhakar Sridhiran
Annette Diehl
Gail Comer
Margot Mary O'toole
Jean Elizabeth Beebe
Robert Fogel
Marek Honczarenko
David Beidler
Padmalatha Sunkara Reddy
Schack David Johannes Von
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2014005570A publication Critical patent/MX2014005570A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

La presente invención se refiere a anticuerpos y porciones de estos de fijación al antígeno que se fijan específicamente a M-CSF, preferentemente M-CSF humano, y que inhiben un M-CSF; la invención también se refiere anticuerpos anti-M-CSF humanos and porciones de estos de fijación al antígeno; la invención también se refiere a anticuerpos que son anticuerpos quiméricos, biespecíficos, derivatizados, monocatenarios o porciones de proteínas de fusión; la invención también se refiere a inmunoglobulinas aisladas de la cadena pesada y cadena liviana que derivan de anticuerpos anti-M-CSF humanos y moléculas de ácido nucleico que codifican esas inmunoglobulinas; la presente invención también se refiere a métodos para obtener anticuerpos anti-M-CSF humanos, composiciones que comprenden estos anticuerpos y métodos para usar los anticuerpos y las composiciones con fines de diagnóstico y tratamiento; la invención también proporciona métodos de terapia génica usando moléculas de ácido nucleico que codifican las moléculas de inmunoglobulina de la cadena pesada y/o cadena liviana que comprenden los anticuerpos anti-M-CSF humanos; la invención también se refiere a animales transgénicos y plantas transgénicas que comprenden moléculas de ácido nucleico de la presente invención.
MX2014005570A 2011-11-08 2012-11-02 El uso de anticuerpos anti factor estimulante de la colonia de macrofagos para tratar trastornos inflamatorios. MX2014005570A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161557175P 2011-11-08 2011-11-08
PCT/IB2012/056125 WO2013068902A1 (en) 2011-11-08 2012-11-02 Methods of treating inflammatory disorders using anti-m-csf antibodies

Publications (1)

Publication Number Publication Date
MX2014005570A true MX2014005570A (es) 2014-05-30

Family

ID=47216377

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014005570A MX2014005570A (es) 2011-11-08 2012-11-02 El uso de anticuerpos anti factor estimulante de la colonia de macrofagos para tratar trastornos inflamatorios.

Country Status (14)

Country Link
US (1) US20140286959A1 (es)
EP (1) EP2776467A1 (es)
JP (1) JP2013100281A (es)
KR (1) KR20140076602A (es)
CN (1) CN104271599A (es)
AU (1) AU2012335247A1 (es)
BR (1) BR112014011115A2 (es)
CA (1) CA2856149A1 (es)
HK (1) HK1205522A1 (es)
IL (1) IL232190A0 (es)
IN (1) IN2014CN04183A (es)
MX (1) MX2014005570A (es)
RU (1) RU2014114015A (es)
WO (1) WO2013068902A1 (es)

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Also Published As

Publication number Publication date
WO2013068902A1 (en) 2013-05-16
IN2014CN04183A (es) 2015-07-17
JP2013100281A (ja) 2013-05-23
HK1205522A1 (en) 2015-12-18
IL232190A0 (en) 2014-06-30
EP2776467A1 (en) 2014-09-17
CA2856149A1 (en) 2013-05-16
BR112014011115A2 (pt) 2017-06-13
US20140286959A1 (en) 2014-09-25
KR20140076602A (ko) 2014-06-20
RU2014114015A (ru) 2015-12-20
AU2012335247A1 (en) 2014-05-29
CN104271599A (zh) 2015-01-07

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