MX2014005403A

MX2014005403A - A liquid hard surface antimicrobial cleaning composition.

Info

Publication number: MX2014005403A
Application number: MX2014005403A
Authority: MX
Inventors: Sameer Keshav Barne; Maya Treesa Saji; Amit Chakrabortty
Original assignee: Unilever Nv
Priority date: 2011-11-03
Filing date: 2012-09-26
Publication date: 2014-07-11
Also published as: WO2013064315A1; EP2773739A1; EA022049B1; EP2773739B1; MX339345B; EA201400533A1; BR112014008053B1; PL2773739T3; BR112014008053A2; CN103890160B; CN103890160A

Abstract

The invention relates to a liquid hard surface cleaning and disinfection composition. The present inventors have found that inclusion of benzalkoniuim chloride and selected salts of di or tricarboxylic acid when combined with thymol or terpineol provides synergistic antimicrobial action in a rapid fashion and such efficacy is obtained at very low concentrations of thymol and/or terpineol.

Description

A CLEANSING COMPOSITION ANTI MICROBIA TO LIQUID DE HARD SURFACE Technical field The invention relates to a liquid hard surface cleaning and disinfecting composition. The invention relates more particularly to a hard surface disinfection composition that provides synergistic antibacterial efficacy.

BACKGROUND OF THE INVENTION Liquid compositions are known for disinfecting and cleaning hard surfaces such as floors, walls, windows, doors, furniture and table tops in various interior and exterior locations. Toilets and toilets are other places where germs proliferate and liquid disinfection and cleaning compositions are widely used. Other types of hard surfaces that are cleaned by such compositions include utensils and other items found in homes, offices and other public places.

Two of the popular classes of disinfectant / sanitizing assets are (i) bleach, and (ii) phenolic. Halogen and active oxygen are two most effective bleaches. Bleaches are compounds that release oxidizing agents such as chlorine, bromine, fluorine, nascent oxygen or other oxidizing agents that break the cell walls of microbes such as bacteria and viruses, thereby disinfecting the surfaces thus treated. Phenolics are another class of antimicrobials frequently derived from ntial oils extracted from natural sources, which are formulated in an emulsified form and sold as floor and toilet cleaner.

These compounds are sometimes considered either hard or take a long time for the antimicrobial action to take place. Very often, these compositions include surfactants either to emulsify the oily components present therein or to allow cleansing via detergency or both. To remove the residual surfactants, the surfaces being treated or cleaned are shortly after rinsed or cleaned to be substantially free of the disinfection / cleaning composition. This allows very little time for the disinfection action to take place.

Therefore, there is a need to provide a composition that provides relatively more effective antimicrobial action, when the cleaning period is relatively small, typically about 5 minutes or l preferably lthan 2 minutes and in many cases lthan one minute or l sometimes as low as 1 5 seconds or l The present applicants have described, in a prior patent application published as Wo2010046238, a novel combination of thymol and terpineol which interact synergistically to allow rapid antimicrobial action in lthan about 15 seconds. The present inventors have found that the inclusion of benzalkonium chloride and selected salts of di or tricarboxylic acid when combined with thymol or terpineol, provides a similar synergistic antimicrobial action in a rapid manner and such efficacy is obtained at much lower concentrations of thymol and / or terpineol. This invention has the advantage that the active ingredients of ntial oils such as terpineol and thymol have a strong medicinal odor, which is not liked by some consumers and it is advantageous to include thymol and terpineol at lower concentrations while ensuring that same efficient antimicrobial action. Furthermore, it has been found by means of the present invention, that the inclusion of a sodium tripolyphosphate chelating agent provides an additional intensified antibacterial efficacy.

Liquid hard surface cleaning compositions having a pH of 9 to 12 comprising cationic surfactant are known.

US6048836 (1,998, P &G) discloses the use, in one composition, of a combination of a chelating agent, a surfactant, and an ntial oil or active ingredient thereof, to provide disinfecting properties.

The patent publication cited above does not solve the problem of slow-acting antimicrobial composition, nor does it describe the synergistic combination of active ingredients described and claimed in the present invention for the fast-acting antimicrobial action to disinfect hard surfaces.

An objective of the present invention is to overcome or improve at least one of the disadvantages of the prior art, or to provide a useful alternative.

Another object of the present invention is to provide a liquid hard surface cleaning and disinfecting composition, which has relatively rapid antimicrobial action.

BRIEF DESCRIPTION OF THE INVENTION According to the first aspect of the invention, there is provided a liquid hard surface antimicrobial cleaning composition with a pH in the range of 9 to 12, comprising (a) 0.5 to 4% by weight of benzalkonium chloride; (b) 0.25 to 3% by weight of di or tricarboxylic acid salt; (c) 0.01 to 2% by weight of an antimicrobial active of essential oil; Y (d) 87 to 97% by weight of water.

According to another aspect of the invention, there is provided a method for cleaning and disinfecting a hard surface comprising applying to said hard surface a composition of the first aspect diluted with water in a weight ratio of 1: 20 to 1: 200.

Detailed description of the invention These and other aspects, features and advantages will become apparent to those of ordinary skill in the art from a reading of the following detailed description and the appended claims. So that there is no doubt, any characteristic of an aspect of the present invention can be used in any other aspect of the invention. The word "comprises" is intended to mean "includes", but not necessarily "consists of" or "composed of". In other words, the steps or options listed need not be exhaustive. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se. Similarly, all percentages are weight / weight percentages unless otherwise indicated.

Except in the operation and comparison examples, or where explicitly stated otherwise, all figures in this description that indicate material quantities or reaction conditions, physical properties of materials and / or use, will be understood as modified by the word "approximately". Unless otherwise specified, the numerical ranges expressed in the format "from x to y" are understood to include x and y. When multiple preferred ranges are described for a specific characteristic in the "from x to y" format, it is understood that all the ranges that combine the different endpoints are also contemplated.

The first aspect of the invention provides a liquid hard surface antimicrobial cleaning composition with a pH in the range of 9 to 12. The composition comprises 0.5 to 4% by weight of benzalkonium chloride; 0.25 to 3% by weight of di or tricarboxylic acid salt; 0.01 to 2% by weight of an essential oil active selected from thymol or terpineol; and 87 to 97% by weight of water.

The composition comprises 0.5 to 4%, more preferably 1 to 2%, more preferably 1.25 to 1.75% chloride cationic surfactant. benzalkonium The composition comprises 0.25 to 3%, preferably 0.5 to 2%, more preferably 0.5 to 1.5% by weight of the di or tricarboxylic acid salt composition. The di or tricarboxylic acid salt is preferably chosen from an oxalate, fumarate, phthalate, maleate, malate, malonate or citrate. The di or tricarboxylic acid salt is most preferably a phthalate, malate, malonate or citrate. Alkali metal or alkaline earth metal salts are preferred, more preferably alkali metal salts of which the sodium salt is highly preferred. The structure of salts of some of the carboxylic acids is given below: Sodium oxalate Sodium fumarate Sodium phthalate Sodium maleate Na4 Na4 Sodium malate Sodium malonate The composition comprises an antimicrobial active of essential oil selected from thymol or terpineol at 0.01 to 2% by weight of the composition.

Preferred antimicrobial compositions of the present invention have thymol greater than 0.05 and less than 0.3% by weight of the composition. Thymol can be added to the antimicrobial composition in purified form. Alternatively, the thyme oil or extract of tomillo comprising thymol can be added to the antimicrobial composition, while ensuring that thymol is present at the desired concentration in the composition of the present invention. Tomil oil or tomil extract is obtained from the thyme plant. The tomillo plant refers to a plant belonging to the genus Thymus and includes but is not limited to the following species: Thymus vulgaris, Thymus zygis, Thymus satureoides, Thymus mastichina, Thymus broussonetti, Thymus macucanus, Thymus pallidus, Thymus algeriensis, Thymus serpyllum, Thymus pulegoide and Thymus citriodorus.

The structures of thymol and its carvacrol isomer are given below: Carvacrol Timol Preferred antimicrobial compositions of the present invention have terpineol greater than 0.05 and less than 1% by weight. Terpineol is preferably selected from alpha-terpi neol, beta-terpineol, gamma-terpi neol or mixtures thereof. It is particularly preferred that terpineol is alpha-terpineol. Terpineol can be added to the antimicrobial composition in purified form. Alternatively, pi oil not comprising terpineol can be added to the antimicrobial composition.

The structure of a terpineol compound is given below: The composition optionally comprises sodium tripolyphosphate (STPP). When present, the STPP is present at 0.25 to 3%, preferably 0.5 to 2%, more preferably 1.25 to 1.75% by weight of the composition.

The composition of the invention comprises water as a preferred carrier. The water is present in 87 to 97%, preferably 90 to 95% by weight of the composition.

A composition of the invention optionally comprises a surfactant. The preferred surfactant is a nonionic surfactant. The nonionic surfactant is preferably present in an amount of 2 to 10% by weight of the composition. Particularly preferred nonionic surfactants are fatty alcohol ethoxylates, preferably C8-C22, more preferably C8C1 6 fatty alcohol ethoxylates, comprising between 1 and 8 ethylene oxide groups. The concentrations of suitable surfactants in liquid hard surface cleaning application forms are preferably from 1 to 5% by weight of the composition.

The composition of the invention has a pH in the range of 9 to 12, preferably in the range of 10.5 to 1 1 .5. This could be achieved by incorporating the essential ingredients of the invention in selected amounts, and can also be achieved by incorporating an alkaline agent. The alkaline agent is preferably sodium carbonate or sodium hydroxide. The alkaline agent is preferably present at 0. 1 to 1% by weight of the composition.

The present inventors have determined that the action Highly effective antimicrobial of the composition of the invention can be achieved in the absence of conventional disinfectants such as bleaching agents, for example, halogens, halogen compounds and bleach based on active oxygen. However a small amount of such bleaches may be present in the composition, for example, less than 1%, preferably less than 0.5%, more preferably less than 0.1% and the effectiveness of the composition is achievable even with the bleaches being absent of the composition. The composition may further comprise several additional ingredients known to a person skilled in the art. Such additional ingredients include but are not limited to: perfumes, pigments, preservatives, emollients, sunscreens, emulsifiers, gelling agents or thickening agents.

The antimicrobial composition can be in the form of a liquid, but the liquid composition can be further thickened to a gel or a paste. The antimicrobial composition of the present invention can be used for cleaning and care of hard surfaces, such as glass, metal, plastic, wood, ceramics and the like.

According to another aspect of the present invention, there is provided a method for cleaning and disinfecting a hard surface comprising applying to said hard surface a composition of the invention diluted with water in a weight ratio of 1: 20 to 1: 200, of preference in a ratio of 1: 40 to 1: 80.

The method preferably comprises a step for rinsing the surface with a suitable solvent, preferably water or the surface It can be cleaned with a suitable cleaner.

The inventors have determined that the composition of the invention provides an antimicrobial action, where the contact time of the antimicrobial actives with the surface is low, that is, of the order of less than 5 minutes, preferably less than 2 minutes, more preferably less one minute and in many cases less than 1 5 seconds.

The invention will now be demonstrated with the aid of the following non-limiting examples.

Examples Examples 1 to 9: Antibacterial efficacy of the composition of the invention Antibacterial compositions for hard surface cleaning were prepared as shown in Table 1 read in conjunction with Table 2. The compositions were tested for antibacterial efficacy using the European Suspension Test BS EN 1276, which is briefly described below: A test suspension of bacteria (1 ml) was added to a sample of the product under a certain dilution condition (8 ml) together with a specific soil (1 ml). The mixture was maintained at 20 ° C for 5 minutes. After this period of contact time, an aliquot was taken and neutralized immediately by a validated method. The number of bacteria in each sample is determined when placing on TSA agar cultures and the reduction in account viable is calculated after incubation for 48 hours.

In Table 1 below the organism used was P. aeruginosa bacterium ATCC 15442 (at 107 cfu / ml concentration); the dilution was 1:60 of the product (a floor cleaner) in hard water. The dirt used was bovine serum albumin (BSA) at 0.03%. The pH of the samples was 11.0.

Table 1 Table 2: Compositions according to Table 1, were prepared using the concentrations of di / carboxylic acids and thymol and / or terpineol as shown below: The data in Table 1 and 2 indicate that the compositions according to the invention (Examples 3, 4, 6, 7, 9, 10) provide an enormously superior antibacterial efficacy as co-covered with compositions outside the invention (Examples 1, 2 , 5, 8).

Examples 1 1 to 13: Experiments similar to Examples 1 to 10 were performed, except that the dilution was 1: 40 and the contact time of the product with the bacteria was 30 seconds instead of 5 minutes. The data are summarized in Table 3.

Table 3 The data in Table 3 indicate that the antibacterial compositions of the invention (Examples 12 and 13) are effective even at short contact times of about 30 seconds.

Examples 14 to 19: Antibacterial efficacy of compositions of the invention with various di / tricarboxylates The compositions as shown in Table 4, were tested for antibacterial efficacy at a dilution of 1: 60 with hard water in a contact time of 5 minutes. The dirt was BSA at 0.3%. The bacteria used was P. aeruginosa ATCC 1 5442 (at 1 07 cfu / ml of cell density). The pH of the compositions was 1 1. The data is shown in Table 4.

Table 4 'STPP: is sodium tripolyphosphate The data in Table 4 indicate that various other di / tricarboxylates can be used in the composition of the invention in the presence of essential oil actives and these samples (Examples 1-5 to 9) give an enormously superior antibacterial efficacy as it is compared to a sample outside the invention (Example 14).

Claims

REIVI N DICACIONES

1 . A liquid cleaning composition, antimicrobial, of hard surfaces, with a pH in the range of 9 to 1 2 comprising (a) 0.5 to 4% by weight of benzalkonium chloride; (b) 0.25 to 3% by weight of a di or tricarboxylic acid salt; (c) 0.01 to 2% by weight of antimicrobial active of essential oil selected from thymol or terpineol; Y (d) 87 to 97% by weight of water.

2. A composition as claimed in claim 1, comprising thymol and terpineol.

3. A position as claimed in claim 1 or 2, wherein di or tricarboxylic acid salt is chosen from an oxalate, fumarate, phthalate, maleate, malate, malonate or citrate.

4. A composition as claimed in claim 3, wherein said di or tricarboxylic acid salt is chosen from a phtha- ate, malate, malonate or citrate.

5. A com position as claimed in any of the preceding claims, comprising 0.25 to 3% sodium triphosphate.

6. A com position as claimed in any of the preceding claims comprising a non-ionic surfactant.

7. A com position as claimed in claim 6, wherein said nonionic surfactant is present in an amount of 2 to 10% by weight of the composition.

8. A composition as claimed in claim 6 or 7, wherein said nonionic surfactant comprises fatty alcohol ethoxylate.

9. A composition as claimed in any of the preceding claims that an alkaline agent selected from sodium carbonate or sodium hydroxide.

10. A composition as claimed in claim 9, wherein said alkaline agent is present in 0.1 to 1% by weight of the composition. eleven . A method for cleaning and disinfecting a hard surface comprising applying to said hard surface a composition as claimed in any of the preceding claims, diluted in water in a weight ratio of 1: 20 to 1: 200.