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MX2014002769A - Anticuerpos neutralizantes para las exotoxinas principales tcda y tcdb de clostridium difficile. - Google Patents

Anticuerpos neutralizantes para las exotoxinas principales tcda y tcdb de clostridium difficile.

Info

Publication number
MX2014002769A
MX2014002769A MX2014002769A MX2014002769A MX2014002769A MX 2014002769 A MX2014002769 A MX 2014002769A MX 2014002769 A MX2014002769 A MX 2014002769A MX 2014002769 A MX2014002769 A MX 2014002769A MX 2014002769 A MX2014002769 A MX 2014002769A
Authority
MX
Mexico
Prior art keywords
tcdb
clostridium difficile
neutralising antibodies
tcda
major
Prior art date
Application number
MX2014002769A
Other languages
English (en)
Inventor
David Paul Humphreys
Daniel John Ligthwood
Kerry Louise Tyson
David Edward Ormonde Knight
Karine Jeannine Madeleine Hervé
Joanne Elizabeth Compson
Matthew Jon Timothy Page
Andrew Charles Payne
Nicola Louise Fisher
Brendon Mackenzie
Matthew Cox
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46881094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2014002769(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of MX2014002769A publication Critical patent/MX2014002769A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91097—Hexosyltransferases (general) (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención describe la derivación y selección de anticuerpos capaces de neutralizar las exotoxinas principales; TcdA y TcdB de Clostridium dificcile. La invención también describe nuevas propiedades de neutralización y unión a antígeno de Mab individuales y mezclas de estos.
MX2014002769A 2011-09-16 2012-09-10 Anticuerpos neutralizantes para las exotoxinas principales tcda y tcdb de clostridium difficile. MX2014002769A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535532P 2011-09-16 2011-09-16
US201261638731P 2012-04-26 2012-04-26
PCT/GB2012/052222 WO2013038156A1 (en) 2011-09-16 2012-09-10 Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile

Publications (1)

Publication Number Publication Date
MX2014002769A true MX2014002769A (es) 2014-06-11

Family

ID=46881094

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014002769A MX2014002769A (es) 2011-09-16 2012-09-10 Anticuerpos neutralizantes para las exotoxinas principales tcda y tcdb de clostridium difficile.

Country Status (30)

Country Link
US (2) US10752676B2 (es)
EP (2) EP2758432B1 (es)
JP (3) JP6152107B2 (es)
KR (1) KR20140063825A (es)
CN (2) CN108424449A (es)
AU (1) AU2012307157B2 (es)
BR (1) BR112014006175B1 (es)
CA (1) CA2848611A1 (es)
CL (1) CL2014000491A1 (es)
CO (1) CO6930310A2 (es)
CY (1) CY1121673T1 (es)
DK (1) DK2758432T3 (es)
EA (1) EA032475B1 (es)
EC (1) ECSP14013316A (es)
ES (1) ES2729278T3 (es)
HK (1) HK1199463A1 (es)
HR (1) HRP20190917T1 (es)
HU (1) HUE043661T2 (es)
IL (1) IL231167A0 (es)
LT (1) LT2758432T (es)
MX (1) MX2014002769A (es)
PE (1) PE20141547A1 (es)
PH (1) PH12014500456A1 (es)
PL (1) PL2758432T3 (es)
PT (1) PT2758432T (es)
SG (2) SG11201400193SA (es)
SI (1) SI2758432T1 (es)
TN (1) TN2014000101A1 (es)
WO (1) WO2013038156A1 (es)
ZA (1) ZA201402760B (es)

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Also Published As

Publication number Publication date
BR112014006175B1 (pt) 2020-02-11
AU2012307157A1 (en) 2014-04-24
KR20140063825A (ko) 2014-05-27
PL2758432T3 (pl) 2019-08-30
LT2758432T (lt) 2019-06-10
JP2020037555A (ja) 2020-03-12
BR112014006175A2 (pt) 2017-04-04
AU2012307157B2 (en) 2017-08-03
EP2758432B1 (en) 2019-03-06
EP2758432A1 (en) 2014-07-30
US10752676B2 (en) 2020-08-25
US20140348844A1 (en) 2014-11-27
CO6930310A2 (es) 2014-04-28
PT2758432T (pt) 2019-06-14
SI2758432T1 (sl) 2019-07-31
US20200377578A1 (en) 2020-12-03
EP3617227A2 (en) 2020-03-04
JP6603685B2 (ja) 2019-11-06
HRP20190917T1 (hr) 2019-07-26
HUE043661T2 (hu) 2019-08-28
EA032475B1 (ru) 2019-06-28
JP2015501286A (ja) 2015-01-15
CY1121673T1 (el) 2020-07-31
PH12014500456A1 (en) 2014-04-14
WO2013038156A1 (en) 2013-03-21
NZ623293A (en) 2016-05-27
JP2017149773A (ja) 2017-08-31
CN108424449A (zh) 2018-08-21
CN103958544B (zh) 2018-04-24
SG10201701055WA (en) 2017-03-30
EA201400345A1 (ru) 2014-09-30
ECSP14013316A (es) 2014-08-29
SG11201400193SA (en) 2014-05-29
JP6152107B2 (ja) 2017-06-21
IL231167A0 (en) 2014-04-30
CN103958544A (zh) 2014-07-30
DK2758432T3 (da) 2019-06-03
TN2014000101A1 (en) 2015-07-01
CA2848611A1 (en) 2013-03-21
PE20141547A1 (es) 2014-10-25
HK1199463A1 (en) 2015-07-03
ZA201402760B (en) 2016-03-30
CL2014000491A1 (es) 2014-12-26
EP3617227A3 (en) 2020-06-03
ES2729278T3 (es) 2019-10-31

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