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MX2014001600A - 3,4-dihidro-1h-[1,8]naftiridinosas antibacterianas sustituidas con ciclopenta[c]pirrol. - Google Patents

3,4-dihidro-1h-[1,8]naftiridinosas antibacterianas sustituidas con ciclopenta[c]pirrol.

Info

Publication number
MX2014001600A
MX2014001600A MX2014001600A MX2014001600A MX2014001600A MX 2014001600 A MX2014001600 A MX 2014001600A MX 2014001600 A MX2014001600 A MX 2014001600A MX 2014001600 A MX2014001600 A MX 2014001600A MX 2014001600 A MX2014001600 A MX 2014001600A
Authority
MX
Mexico
Prior art keywords
naphthyridinones
dihydro
pyrrole substituted
cyclopenta
antibacterial
Prior art date
Application number
MX2014001600A
Other languages
English (en)
Other versions
MX348128B (es
Inventor
Jerôme Emile Georges Guillemont
Anil Koul
David Francis Alain Lançois
Magali Madeleine Simone Motte
Wendy Mia Albert Balemans
Eric Pierre Alexandre Arnoult
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46650549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2014001600(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of MX2014001600A publication Critical patent/MX2014001600A/es
Publication of MX348128B publication Critical patent/MX348128B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se relaciona con compuestos novedosos de fórmula (I) que inhiben la actividad de la enzima Fabl que, por lo tanto, son útiles para el tratamiento de infecciones bacterianas; se relaciona además con composiciones farmacéuticas que comprenden estos compuestos y con procesos químicos para preparar estos compuestos. (ver Fórmula).
MX2014001600A 2011-08-10 2012-08-10 3,4-dihidro-1h-[1,8]naftiridinonas antibacterianas sustituidas con ciclopenta[c]pirrol. MX348128B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11177119 2011-08-10
PCT/EP2012/065733 WO2013021054A1 (en) 2011-08-10 2012-08-10 Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1h-[1,8]naphthyridinones

Publications (2)

Publication Number Publication Date
MX2014001600A true MX2014001600A (es) 2014-04-25
MX348128B MX348128B (es) 2017-05-26

Family

ID=46650549

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001600A MX348128B (es) 2011-08-10 2012-08-10 3,4-dihidro-1h-[1,8]naftiridinonas antibacterianas sustituidas con ciclopenta[c]pirrol.

Country Status (24)

Country Link
US (7) US8906923B2 (es)
EP (1) EP2742045B1 (es)
JP (2) JP5921687B2 (es)
KR (1) KR101996862B1 (es)
CN (2) CN105461684B (es)
AR (1) AR087508A1 (es)
AU (1) AU2012293621B2 (es)
BR (1) BR112014003063B1 (es)
CA (1) CA2842518C (es)
CL (1) CL2014000289A1 (es)
DK (1) DK2742045T3 (es)
EA (1) EA201490438A1 (es)
ES (1) ES2721658T3 (es)
HU (1) HUE042978T2 (es)
IL (1) IL230549A (es)
JO (1) JO3611B1 (es)
MX (1) MX348128B (es)
PE (1) PE20141410A1 (es)
PH (1) PH12014500317A1 (es)
TR (1) TR201905537T4 (es)
TW (1) TWI568731B (es)
UA (1) UA111210C2 (es)
UY (1) UY34253A (es)
WO (1) WO2013021054A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
BR112014002958B1 (pt) 2011-08-10 2020-10-06 Janssen Sciences Ireland Uc 3,4-dihidro-1h-[1,8]naftiridinonas substituídas com piperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso
US9315522B2 (en) * 2012-08-10 2016-04-19 Janssen Sciences Ireland Uc Antibacterial compounds
AR097794A1 (es) 2013-09-26 2016-04-13 Mnemosyne Pharmaceuticals Inc Moduladores octahidro-ciclopenta[c]pirrol negativos de nr2b
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
SI3448859T1 (sl) 2017-03-20 2020-02-28 Forma Therapeutics, Inc. Sestavki pirolopirola kot aktivatorji piruvat kinaze (PKR)
US11691967B2 (en) 2018-03-12 2023-07-04 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r
KR102872166B1 (ko) 2018-11-12 2025-10-15 데비오팜 인터네셔날 에스 에이 항생제 화합물, 이의 제조 방법, 이를 포함하는 약학적 조성물 및 그 용도
BR112022004376A2 (pt) 2019-09-19 2022-06-07 Forma Therapeutics Inc Ativação de piruvato quinase r
AU2022236404A1 (en) * 2021-03-17 2023-11-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215123A (en) * 1979-05-07 1980-07-29 American Home Products Corporation Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
ES2270874T3 (es) 1999-10-08 2007-04-16 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
CZ302015B6 (cs) 1999-10-08 2010-09-08 Affinium Pharmaceuticals, Inc. Inhibitory Fab I
EP1225895B1 (en) 1999-10-08 2005-05-04 Affinium Pharmaceuticals, Inc. Fab i inhibitors
JP4387804B2 (ja) 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
KR101299399B1 (ko) * 2004-06-04 2013-08-22 아피늄 파마슈티컬스, 인크. 치료제, 및 그의 제조 및 사용 방법
US7732612B2 (en) 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7973060B2 (en) 2005-10-13 2011-07-05 Crystalgenomics, Inc. Fab I inhibitor and process for preparing same
EP2687533B1 (en) * 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
EP2501693B1 (en) * 2009-11-18 2014-09-17 FAB Pharma SAS Aza heterocyclic acrylamides and their use as bactericides
JP2014524409A (ja) 2011-07-29 2014-09-22 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア Ｈｉｖの治療のための組成物および方法
US8766017B2 (en) 2011-07-29 2014-07-01 Eastman Chemical Company Integrated process for the preparation of 1,4-cyclohexanedimethanol from terephthalic acid
EA038317B1 (ru) 2011-08-10 2021-08-09 Янссен Сайенсиз Айрлэнд Юси Антибактериальные 3,4-дигидро-1н-[1,8]нафтиридиноны, замещенные гомопиперидинилом
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
BR112014002958B1 (pt) 2011-08-10 2020-10-06 Janssen Sciences Ireland Uc 3,4-dihidro-1h-[1,8]naftiridinonas substituídas com piperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso

Also Published As

Publication number Publication date
US20190194194A1 (en) 2019-06-27
DK2742045T3 (en) 2019-04-23
UA111210C2 (uk) 2016-04-11
KR20140072034A (ko) 2014-06-12
US9290493B2 (en) 2016-03-22
US10526331B2 (en) 2020-01-07
AU2012293621A1 (en) 2014-02-13
US9617262B2 (en) 2017-04-11
CN103874698A (zh) 2014-06-18
IL230549A0 (en) 2014-03-31
WO2013021054A1 (en) 2013-02-14
EP2742045B1 (en) 2019-01-23
BR112014003063B1 (pt) 2020-11-17
AU2012293621B2 (en) 2016-07-21
EA201490438A1 (ru) 2014-06-30
HUE042978T2 (hu) 2019-07-29
IL230549A (en) 2017-07-31
ES2721658T3 (es) 2019-08-02
CA2842518C (en) 2019-07-23
US20180105525A1 (en) 2018-04-19
CA2842518A1 (en) 2013-02-14
TWI568731B (zh) 2017-02-01
PH12014500317A1 (en) 2014-04-14
AR087508A1 (es) 2014-03-26
CN105461684A (zh) 2016-04-06
KR101996862B1 (ko) 2019-07-05
JP2016190843A (ja) 2016-11-10
NZ620212A (en) 2015-10-30
US10501463B2 (en) 2019-12-10
TR201905537T4 (tr) 2019-05-21
BR112014003063A2 (pt) 2017-02-21
US20140171451A1 (en) 2014-06-19
CN103874698B (zh) 2016-03-23
JP2014531404A (ja) 2014-11-27
CN105461684B (zh) 2018-09-25
US20190084982A1 (en) 2019-03-21
CL2014000289A1 (es) 2014-07-11
US20170174683A1 (en) 2017-06-22
EP2742045A1 (en) 2014-06-18
US9884864B2 (en) 2018-02-06
JO3611B1 (ar) 2020-08-27
US20150080413A1 (en) 2015-03-19
MX348128B (es) 2017-05-26
US8906923B2 (en) 2014-12-09
US20160194324A1 (en) 2016-07-07
US10155759B2 (en) 2018-12-18
UY34253A (es) 2013-02-28
HK1199243A1 (zh) 2015-06-26
HK1223352A1 (zh) 2017-07-28
JP5921687B2 (ja) 2016-05-24
PE20141410A1 (es) 2014-10-13
TW201313714A (zh) 2013-04-01

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