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MX2014000937A - Compuesto de amidina o sal del mismo. - Google Patents

Compuesto de amidina o sal del mismo.

Info

Publication number
MX2014000937A
MX2014000937A MX2014000937A MX2014000937A MX2014000937A MX 2014000937 A MX2014000937 A MX 2014000937A MX 2014000937 A MX2014000937 A MX 2014000937A MX 2014000937 A MX2014000937 A MX 2014000937A MX 2014000937 A MX2014000937 A MX 2014000937A
Authority
MX
Mexico
Prior art keywords
group
formula
different
independently represent
same
Prior art date
Application number
MX2014000937A
Other languages
English (en)
Other versions
MX336268B (es
Inventor
Yasuhiro Tsutsui
Toru Yamaguchi
Yasunobu Ushiki
Tetsuya Tanikawa
Fumihito Ushiyama
Naoya Ono
Keiko Yamamoto
Risa Tsuruta
Noritomo Fujino
Ayumu MORI
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of MX2014000937A publication Critical patent/MX2014000937A/es
Publication of MX336268B publication Critical patent/MX336268B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

El propósito de la presente invención es proporcionar un compuesto novedoso que tiene actividad antimicótica en hongos patogénicos, incluyendo los hongos que pertenecen al género Candida, al género Aspergillus y al género Trichophyton, y que es útil como un agente medicinal. Un compuesto representado por la fórmula (I) (en donde A' representa un átomo de nitrógeno o un grupo representado por la fórmula CR6 A2 y A3 son los mismos o diferentes uno de otro y representan de manera independiente, un átomo de nitrógeno o un grupo representado por la fórmula CH; R1 representa un grupo arilo que puede estar sustituido con 1 a 5 sustituyentes, seleccionados de manera independiente de un grupo de sustituyentes (2) o lo similar; R2 y R3 son los mismos o diferentes uno de otro y representan de manera independiente, un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo de C1-6, un grupo haloalquilo de C1-6 o un grupo alcoxi de C1-6 y R4 y R5 son los mismos o diferentes uno de otro y representan de manera independiente, un átomo de hidrógeno, un grupo haloalquilo de C1-6, un grupo alquilo de C, o lo similar) o una sal del mismo, que es útil como un agente antimicótico.
MX2014000937A 2011-07-29 2012-07-27 Compuesto de amidina o sal del mismo. MX336268B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011167754 2011-07-29
PCT/JP2012/069249 WO2013018735A1 (ja) 2011-07-29 2012-07-27 アミジン化合物又はその塩

Publications (2)

Publication Number Publication Date
MX2014000937A true MX2014000937A (es) 2014-04-30
MX336268B MX336268B (es) 2016-01-13

Family

ID=47629258

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000937A MX336268B (es) 2011-07-29 2012-07-27 Compuesto de amidina o sal del mismo.

Country Status (12)

Country Link
US (1) US9045466B2 (es)
EP (1) EP2738163B1 (es)
JP (1) JPWO2013018735A1 (es)
KR (1) KR20140045511A (es)
CN (1) CN103797000B (es)
AU (1) AU2012291133A1 (es)
BR (1) BR112014001265A2 (es)
CA (1) CA2843383A1 (es)
ES (1) ES2563232T3 (es)
MX (1) MX336268B (es)
RU (1) RU2014107744A (es)
WO (1) WO2013018735A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014119617A1 (ja) * 2013-01-30 2014-08-07 富山化学工業株式会社 アミジン化合物またはその塩
CN103304474A (zh) * 2013-06-03 2013-09-18 石玉芳 ω,ω,ω’,ω’-四溴-2,6-二乙酰基吡啶及其合成方法
WO2015025962A1 (ja) * 2013-08-23 2015-02-26 富山化学工業株式会社 アミジン化合物またはその塩
WO2016043260A1 (ja) * 2014-09-19 2016-03-24 塩野義製薬株式会社 環状グアニジンまたはアミジン化合物
UA125628C2 (uk) * 2016-10-14 2022-05-04 Пі Індастріз Лтд Похідні 4-заміщеного феніламіну і їх використання для захисту культур від небажаних фітопатогенних мікроорганізмів
CA3059301A1 (en) 2017-04-20 2018-10-25 Pi Industries Ltd. Novel phenylamine compounds
EP3625215B1 (en) * 2017-05-18 2023-09-13 PI Industries Ltd Formimidamidine compounds useful against phytopathogenic microorganisms
CN109553532B (zh) * 2018-12-21 2021-04-02 荆门医药工业技术研究院 一种4-溴乙酰基-2-甲基苯甲酸甲酯的制备方法
IT201900021216A1 (it) 2019-11-14 2021-05-14 Isagro Spa Processo per la preparazione di derivati piridinici e corrispondenti piridil-formammidine
CN115403526A (zh) * 2022-09-21 2022-11-29 韶远科技（上海)有限公司 一种5-乙酰基嘧啶的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9902592D0 (en) 1999-02-06 1999-03-24 Hoechst Schering Agrevo Gmbh Fungicides
GB0021421D0 (en) * 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
EP1413301A1 (fr) 2002-10-24 2004-04-28 Bayer CropScience SA Médicaments antifongiques à base de dérivés d'arylamidine
AU2004247560B2 (en) 2003-06-11 2007-11-29 Sankyo Company, Limited Cyclic tertiary amine compound
EP1758579A1 (en) 2004-05-29 2007-03-07 7TM Pharma A/S Crth2 receptor ligands for medicinal uses
CN101044127A (zh) 2004-08-23 2007-09-26 惠氏公司 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸
KR100848205B1 (ko) 2005-06-20 2008-07-24 주식회사 동부하이텍 면역 억제 및 염증 억제 활성을 갖는 신규한 치환된1,3-티아졸 유도체 또는 이의 약학적으로 허용가능한 염,중간체 화합물 또는 이의 약학적으로 허용가능한 염, 이의제조방법, 및 이를 포함하는 약학적 조성물
AR056507A1 (es) * 2005-09-13 2007-10-10 Bayer Cropscience Ag Derivados plaguicidas de fenilamidina sustituida con tiazoliloxi
EP1969931A1 (de) * 2007-03-12 2008-09-17 Bayer CropScience Aktiengesellschaft Fluoalkylphenylamidine und deren Verwendung als Fungizide
EP1974729A1 (en) 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
EP2195287A1 (en) 2007-09-28 2010-06-16 GlaxoSmithKline LLC Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof
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EP2488520B1 (en) 2009-10-13 2015-09-02 Merck Sharp & Dohme B.V. Condensed azine-derivatives for the treatment of diseases related to the acetylcholine receptor

Also Published As

Publication number Publication date
WO2013018735A1 (ja) 2013-02-07
US9045466B2 (en) 2015-06-02
EP2738163A1 (en) 2014-06-04
EP2738163A4 (en) 2014-12-10
JPWO2013018735A1 (ja) 2015-03-05
CN103797000B (zh) 2016-07-06
BR112014001265A2 (pt) 2017-02-21
AU2012291133A1 (en) 2014-02-20
ES2563232T3 (es) 2016-03-11
RU2014107744A (ru) 2015-09-10
KR20140045511A (ko) 2014-04-16
CN103797000A (zh) 2014-05-14
CA2843383A1 (en) 2013-02-07
EP2738163B1 (en) 2016-01-20
US20140155597A1 (en) 2014-06-05
MX336268B (es) 2016-01-13

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