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MX2013013937A - Anticuerpos del receptor eritropoyetina (epo) anti-humana y metodos de uso. - Google Patents

Anticuerpos del receptor eritropoyetina (epo) anti-humana y metodos de uso.

Info

Publication number
MX2013013937A
MX2013013937A MX2013013937A MX2013013937A MX2013013937A MX 2013013937 A MX2013013937 A MX 2013013937A MX 2013013937 A MX2013013937 A MX 2013013937A MX 2013013937 A MX2013013937 A MX 2013013937A MX 2013013937 A MX2013013937 A MX 2013013937A
Authority
MX
Mexico
Prior art keywords
epo receptor
methods
human epo
receptor antibodies
human
Prior art date
Application number
MX2013013937A
Other languages
English (en)
Other versions
MX343117B (es
Inventor
Olaf Mundigl
Michael Jarsch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013013937A publication Critical patent/MX2013013937A/es
Publication of MX343117B publication Critical patent/MX343117B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En la presente se describe un anticuerpo que se une de forma específica al receptor de la EPO humana, en donde el anticuerpo se une al fragmento del receptor de la EPO LPGPGGSVDIV (SEC ID NO: 01) pero no se une específicamente a una proteína que puede obtenerse a partir de células endoteliales humanas que posee un peso molecular de alrededor de 66 kD.
MX2013013937A 2011-06-15 2012-06-14 Anticuerpos del receptor eritropoyetina (epo) anti-humana y metodos de uso. MX343117B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11170020 2011-06-15
PCT/EP2012/061288 WO2012171996A1 (en) 2011-06-15 2012-06-14 Anti-human epo receptor antibodies and methods of use

Publications (2)

Publication Number Publication Date
MX2013013937A true MX2013013937A (es) 2013-12-16
MX343117B MX343117B (es) 2016-10-25

Family

ID=45044836

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013937A MX343117B (es) 2011-06-15 2012-06-14 Anticuerpos del receptor eritropoyetina (epo) anti-humana y metodos de uso.

Country Status (14)

Country Link
US (2) US8623666B2 (es)
EP (1) EP2721067B1 (es)
JP (1) JP5984919B2 (es)
KR (1) KR101629073B1 (es)
CN (1) CN103596984B (es)
AR (1) AR086924A1 (es)
AU (1) AU2012269075B2 (es)
BR (1) BR112013032235A2 (es)
CA (1) CA2837914A1 (es)
IL (1) IL229764A0 (es)
MX (1) MX343117B (es)
MY (1) MY166974A (es)
RU (1) RU2013158627A (es)
WO (1) WO2012171996A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013355414B2 (en) 2012-12-05 2017-02-02 Novartis Ag Compositions and methods for antibodies targeting EPO
KR101539150B1 (ko) * 2013-12-26 2015-07-27 가톨릭대학교 산학협력단 자가면역 항체 검출방법 및 이를 이용한 자가면역 항체 검출키트
CN106338423B (zh) 2015-07-10 2020-07-14 三斯坎公司 组织学染色的空间复用
JP2018525389A (ja) 2015-08-12 2018-09-06 ノバルティス アーゲー 眼障害を治療する方法

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Also Published As

Publication number Publication date
IL229764A0 (en) 2014-01-30
CA2837914A1 (en) 2012-12-20
US20120321633A1 (en) 2012-12-20
EP2721067A1 (en) 2014-04-23
JP5984919B2 (ja) 2016-09-06
AU2012269075A1 (en) 2013-05-02
RU2013158627A (ru) 2015-07-20
BR112013032235A2 (pt) 2016-11-22
MX343117B (es) 2016-10-25
CN103596984B (zh) 2016-04-13
MY166974A (en) 2018-07-27
US20140193418A1 (en) 2014-07-10
AR086924A1 (es) 2014-01-29
KR101629073B1 (ko) 2016-06-09
NZ617936A (en) 2015-10-30
US9187563B2 (en) 2015-11-17
HK1193615A1 (zh) 2014-09-26
AU2012269075B2 (en) 2015-05-21
CN103596984A (zh) 2014-02-19
JP2014528693A (ja) 2014-10-30
EP2721067B1 (en) 2019-07-31
WO2012171996A1 (en) 2012-12-20
US8623666B2 (en) 2014-01-07
KR20140013076A (ko) 2014-02-04

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