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MX2013012791A - Analogos del factor b del complemento y sus usos. - Google Patents

Analogos del factor b del complemento y sus usos.

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Publication number
MX2013012791A
MX2013012791A MX2013012791A MX2013012791A MX2013012791A MX 2013012791 A MX2013012791 A MX 2013012791A MX 2013012791 A MX2013012791 A MX 2013012791A MX 2013012791 A MX2013012791 A MX 2013012791A MX 2013012791 A MX2013012791 A MX 2013012791A
Authority
MX
Mexico
Prior art keywords
analogs
complement factor
complement
vectors
nucleic acids
Prior art date
Application number
MX2013012791A
Other languages
English (en)
Other versions
MX350445B (es
Inventor
Michael Kaleko
Changhung Chen
Beibei Li
Tianci Luo
Jeffrey Allen Miller
Ruigong Wang
Original Assignee
Wellstat Immunotherapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Immunotherapeutics Llc filed Critical Wellstat Immunotherapeutics Llc
Publication of MX2013012791A publication Critical patent/MX2013012791A/es
Publication of MX350445B publication Critical patent/MX350445B/es

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
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Abstract

La invención proporciona polipéptidos que comprenden un análogo del factor B del complemento. La invención también proporciona varios análogos del factor B del complemento que incluyen análogos del factor B del complemento que comprenden una mutación de un aminoácido de cisteína libre y métodos, ácidos nucleicos y vectores relacionados. Estos análogos del factor B del complemento y métodos, ácidos nucleicos y vectores relacionados se pueden utilizar para modular una vía del complemento o para el estudio y/o tratamiento de varias condiciones o enfermedades relacionadas con una vía del complemento. La figura más representativa de la invención es la número 1A.
MX2013012791A 2011-05-05 2012-05-04 Analogos del factor b del complemento y sus usos. MX350445B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161482827P 2011-05-05 2011-05-05
US201161497835P 2011-06-16 2011-06-16
US201161568518P 2011-12-08 2011-12-08
PCT/US2012/036459 WO2012151468A1 (en) 2011-05-05 2012-05-04 Complement factor b analogs and their uses

Publications (2)

Publication Number Publication Date
MX2013012791A true MX2013012791A (es) 2014-04-14
MX350445B MX350445B (es) 2017-09-07

Family

ID=47108062

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012791A MX350445B (es) 2011-05-05 2012-05-04 Analogos del factor b del complemento y sus usos.

Country Status (16)

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US (5) US9228003B2 (es)
EP (1) EP2704744B1 (es)
JP (2) JP6162102B2 (es)
KR (1) KR101949293B1 (es)
CN (1) CN103561765B (es)
AU (1) AU2012250614B2 (es)
BR (1) BR112013028271B1 (es)
CA (1) CA2833931C (es)
DK (1) DK2704744T3 (es)
ES (1) ES2738628T3 (es)
IL (1) IL229243B (es)
MX (1) MX350445B (es)
RU (1) RU2639521C2 (es)
SG (1) SG194780A1 (es)
WO (1) WO2012151468A1 (es)
ZA (1) ZA201307589B (es)

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AU2012250614B2 (en) 2016-02-11
ZA201307589B (en) 2014-07-30
DK2704744T3 (da) 2019-07-15
JP6162102B2 (ja) 2017-07-12
WO2012151468A1 (en) 2012-11-08
US20190338268A1 (en) 2019-11-07
MX350445B (es) 2017-09-07
JP2017113035A (ja) 2017-06-29
RU2639521C2 (ru) 2017-12-21
US20200325464A1 (en) 2020-10-15
CN103561765B (zh) 2015-06-17
US20170037391A1 (en) 2017-02-09
EP2704744A4 (en) 2015-01-21
KR101949293B1 (ko) 2019-02-18
US9533028B2 (en) 2017-01-03
JP2014518621A (ja) 2014-08-07
ES2738628T3 (es) 2020-01-24
US20160082091A1 (en) 2016-03-24
CA2833931A1 (en) 2012-11-08
AU2012250614A1 (en) 2013-05-02
RU2013153902A (ru) 2015-06-10
KR20140047038A (ko) 2014-04-21
EP2704744A1 (en) 2014-03-12
BR112013028271A2 (pt) 2017-09-19
IL229243B (en) 2021-06-30
US10689637B2 (en) 2020-06-23
BR112013028271B1 (pt) 2020-11-24
US9228003B2 (en) 2016-01-05
EP2704744B1 (en) 2019-04-24
US11001822B2 (en) 2021-05-11
IL229243A0 (en) 2014-01-30
CA2833931C (en) 2021-05-04
SG194780A1 (en) 2013-12-30
US10415026B2 (en) 2019-09-17
US20140249072A1 (en) 2014-09-04
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CN103561765A (zh) 2014-02-05

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