MX2013011490A - Derivados de piridopirazina y su uso. - Google Patents
Derivados de piridopirazina y su uso.Info
- Publication number
- MX2013011490A MX2013011490A MX2013011490A MX2013011490A MX2013011490A MX 2013011490 A MX2013011490 A MX 2013011490A MX 2013011490 A MX2013011490 A MX 2013011490A MX 2013011490 A MX2013011490 A MX 2013011490A MX 2013011490 A MX2013011490 A MX 2013011490A
- Authority
- MX
- Mexico
- Prior art keywords
- pyridopyrazine derivatives
- pyridopyrazine
- derivatives
- mammals
- enzymes
- Prior art date
Links
- YEYHFKBVNARCNE-UHFFFAOYSA-N pyrido[2,3-b]pyrazine Chemical class N1=CC=NC2=CC=CN=C21 YEYHFKBVNARCNE-UHFFFAOYSA-N 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000001991 pathophysiological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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Abstract
La presente invención proporciona nuevos compuestos de piridopirazina que son adecuados para el tratamiento o prevención de estados fisiológicos o patofisiológicos mediados y/o modulados por las rutas de transducción de señal y/o enzimas en mamíferos y en particular en humanos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472245P | 2011-04-06 | 2011-04-06 | |
| EP11161248A EP2508184A1 (en) | 2011-04-06 | 2011-04-06 | Pyridopyrazine derivatives and their use |
| PCT/EP2012/056142 WO2012136694A1 (en) | 2011-04-06 | 2012-04-04 | Pyridopyrazine derivatives and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013011490A true MX2013011490A (es) | 2013-11-04 |
Family
ID=44350566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013011490A MX2013011490A (es) | 2011-04-06 | 2012-04-04 | Derivados de piridopirazina y su uso. |
| MX2013011444A MX2013011444A (es) | 2011-04-06 | 2012-04-04 | Derivados de piridopirazina y sus usos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013011444A MX2013011444A (es) | 2011-04-06 | 2012-04-04 | Derivados de piridopirazina y sus usos. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8912189B2 (es) |
| EP (3) | EP2508184A1 (es) |
| JP (2) | JP5963844B2 (es) |
| KR (2) | KR20140025442A (es) |
| CN (2) | CN103501788A (es) |
| AR (2) | AR085844A1 (es) |
| AU (2) | AU2012238681A1 (es) |
| BR (1) | BR112013025630A2 (es) |
| CA (2) | CA2832337A1 (es) |
| ES (1) | ES2552515T3 (es) |
| IL (2) | IL228436A0 (es) |
| MX (2) | MX2013011490A (es) |
| NZ (1) | NZ615578A (es) |
| PH (1) | PH12013501904A1 (es) |
| PL (1) | PL2694067T3 (es) |
| RU (2) | RU2013146618A (es) |
| SG (2) | SG194097A1 (es) |
| TW (2) | TW201302742A (es) |
| WO (2) | WO2012136691A1 (es) |
| ZA (2) | ZA201306864B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017033113A1 (en) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Therapeutic combinations of a mek inhibitor and a btk inhibitor |
| US20170168056A1 (en) * | 2015-11-13 | 2017-06-15 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating cancer cells |
| CN109311868B (zh) | 2015-12-22 | 2022-04-01 | 尚医治疗有限责任公司 | 用于治疗癌症和炎性疾病的化合物 |
| WO2017180817A1 (en) * | 2016-04-15 | 2017-10-19 | Musc Foundation For Research Development | Treatment of septicemia and ards with erk inhibitors |
| EA201992780A1 (ru) | 2017-06-21 | 2020-06-02 | ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи | Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания |
| US20200138921A1 (en) * | 2017-06-23 | 2020-05-07 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating diseases characterized by synaptic dysfunction and neurodegeneration including alzheimer's disease |
| EP3806833A1 (en) | 2018-06-15 | 2021-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity |
| EP3898609A1 (en) | 2018-12-19 | 2021-10-27 | Shy Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| CN112830897B (zh) * | 2019-11-22 | 2022-09-09 | 石家庄以岭药业股份有限公司 | 含脲基苯并咪唑类衍生物及其制备方法和应用 |
| US20240109883A1 (en) | 2020-12-31 | 2024-04-04 | Evrys Bio, Llc | Anti-Tumor Compositions and Methods |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3809695A (en) | 1967-04-19 | 1974-05-07 | Degussa | 2,6-dichloro-3-nitro-pyridine |
| KR100369275B1 (ko) | 1995-03-28 | 2003-05-09 | 스미또모 가가꾸 고오교오 가부시끼가이샤 | 아미노니트로피리딘류의제조방법 |
| UA71555C2 (en) | 1997-10-06 | 2004-12-15 | Zentaris Gmbh | Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives |
| EP1041982B1 (en) | 1997-12-22 | 2011-10-19 | Bayer HealthCare LLC | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
| WO2003024448A2 (en) | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2003068223A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
| US20060142178A1 (en) | 2002-04-08 | 2006-06-29 | Barnett Stanley F | Method of treating cancer |
| EP1496896A4 (en) | 2002-04-08 | 2007-10-31 | Merck & Co Inc | AKT INHIBITORS EFFECT |
| EP1496906A4 (en) | 2002-04-08 | 2006-05-03 | Merck & Co Inc | HEMMER OF ACT ACTIVITY |
| WO2004005472A2 (en) | 2002-07-02 | 2004-01-15 | Southern Research Institute | Inhibitors of ftsz and uses thereof |
| JP4571944B2 (ja) | 2003-05-23 | 2010-10-27 | エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のピリドピラジン及びそれらのキナーゼモジュレーターとしての使用 |
| DE10323345A1 (de) | 2003-05-23 | 2004-12-16 | Zentaris Gmbh | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
| WO2005007099A2 (en) | 2003-07-10 | 2005-01-27 | Imclone Systems Incorporated | Pkb inhibitors as anti-tumor agents |
| US7592340B2 (en) | 2003-12-04 | 2009-09-22 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| GB0413953D0 (en) | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
| EP1785423A1 (de) * | 2005-11-11 | 2007-05-16 | Zentaris GmbH | Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| KR101400905B1 (ko) | 2005-11-11 | 2014-05-29 | 아에테르나 젠타리스 게엠베하 | 신규한 피리도피라진 및 키나제의 조절제로서의 이의 용도 |
| EP1790342A1 (de) * | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| US7733554B2 (en) * | 2006-03-08 | 2010-06-08 | E Ink Corporation | Electro-optic displays, and materials and methods for production thereof |
| KR101097177B1 (ko) | 2006-07-06 | 2011-12-22 | 한국화학연구원 | 2-알킬레닐옥시-3-에티닐피리도［2,3-ｂ］피라진 유도체 |
| GB0614471D0 (en) | 2006-07-20 | 2006-08-30 | Syngenta Ltd | Herbicidal Compounds |
| US20100093738A1 (en) | 2006-10-06 | 2010-04-15 | Basf Se | Fungicidal Compounds and Fungicidal Compositions |
| EP1990342A1 (en) * | 2007-05-10 | 2008-11-12 | AEterna Zentaris GmbH | Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof |
| MX2010005960A (es) | 2007-11-30 | 2010-06-11 | Schering Corp | Biomarcadores de braf. |
| KR101665143B1 (ko) | 2007-12-19 | 2016-10-11 | 캔써 리서치 테크놀로지 리미티드 | 피리도[2,3-ｂ]피라진-8 치환 화합물 및 이의 용도 |
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