MX2013011272A - Derivado de oxazolidinona novedoso y composicion farmaceutica que incluye el mismo. - Google Patents
Derivado de oxazolidinona novedoso y composicion farmaceutica que incluye el mismo.Info
- Publication number
- MX2013011272A MX2013011272A MX2013011272A MX2013011272A MX2013011272A MX 2013011272 A MX2013011272 A MX 2013011272A MX 2013011272 A MX2013011272 A MX 2013011272A MX 2013011272 A MX2013011272 A MX 2013011272A MX 2013011272 A MX2013011272 A MX 2013011272A
- Authority
- MX
- Mexico
- Prior art keywords
- novel oxazolidinone
- oxazolidinone derivative
- chemical formula
- present
- composition containing
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000126 substance Substances 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000438 amidrazone group Chemical group 0.000 abstract 1
- SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical compound C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- -1 oxazolidinone compound Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describe un derivado de oxazolidinona novedoso representado por la fórmula 1 anterior, en particular, un compuesto de oxazolidinona novedoso que tiene a grupo amidoxima cíclica o amidrazona cíclica; en la fórmula 1, R y Q son los mismos que definen en la descripción detallada; además, se describe una composición farmacéutica para un antibiótico que incluye el derivado de oxazolidinona novedoso de la fórmula 1, un profármaco del mismo, un hidrato del mismo, un solvato del mismo, un isómero del mismo, o una sal farmacéuticamente aceptable del mismo como un ingrediente activo; el derivado de oxazolidinona novedoso, el profármaco del mismo, el hidrato del mismo, el solvato del mismo, el isómero del mismo, y la sal farmacéuticamente aceptable del mismo tienen amplio espectro antibacteriano contra bacterias resistentes, baja toxicidad y efectos antibacterianos fuertes contra bacterias Gram-positivas y Gram-negativas y por lo tanto se pueden usar de manera efectiva como antibióticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110028559A KR101653570B1 (ko) | 2011-03-30 | 2011-03-30 | 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
| PCT/KR2012/002314 WO2012134188A2 (ko) | 2011-03-30 | 2012-03-29 | 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013011272A true MX2013011272A (es) | 2014-03-21 |
| MX337409B MX337409B (es) | 2016-03-02 |
Family
ID=46932138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013011272A MX337409B (es) | 2011-03-30 | 2012-03-29 | Derivado de oxazolidinona novedoso y composicion farmaceutica que incluye el mismo. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8846669B2 (es) |
| EP (2) | EP3372598A1 (es) |
| JP (1) | JP6072764B2 (es) |
| KR (1) | KR101653570B1 (es) |
| CN (1) | CN103476772B (es) |
| AU (1) | AU2012237067B2 (es) |
| BR (1) | BR112013024497A2 (es) |
| CA (1) | CA2831799A1 (es) |
| MX (1) | MX337409B (es) |
| RU (1) | RU2617408C2 (es) |
| WO (1) | WO2012134188A2 (es) |
| ZA (1) | ZA201307216B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104774198A (zh) * | 2014-01-15 | 2015-07-15 | 上海美迪西生物医药有限公司 | 一种新噁唑烷酮类化合物及其制备方法 |
| CN106928214A (zh) * | 2014-09-17 | 2017-07-07 | 博瑞生物医药（苏州）股份有限公司 | 一种噁唑烷酮类化合物及其中间体的制备方法 |
| US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
| CN106045934A (zh) * | 2015-10-27 | 2016-10-26 | 博瑞生物医药（苏州）股份有限公司 | 一种合成泰地唑胺的中间体的晶型 |
| CN107722056A (zh) * | 2017-10-31 | 2018-02-23 | 重庆华邦胜凯制药有限公司 | 磷酸特地唑胺的制备方法 |
| CN115650908A (zh) * | 2022-09-26 | 2023-01-31 | 南京康立瑞生物科技有限公司 | 一种5-溴-2氰基吡啶的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8506659A1 (es) | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| CN1433413A (zh) * | 2000-06-05 | 2003-07-30 | 东亚制药株式会社 | 新的噁唑烷酮衍生物及其制备方法 |
| KR100731469B1 (ko) * | 2000-06-05 | 2007-06-21 | 동아제약주식회사 | 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법 |
| GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229522D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| TW200500360A (en) * | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
| KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2005116024A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections |
| US20100286211A1 (en) * | 2004-10-08 | 2010-11-11 | Biswajit Das | Oxazolidinone derivatives as antimicrobials |
| EP1912980A2 (en) * | 2005-06-20 | 2008-04-23 | Wockhardt Limited | Oxazolidinones bearing antimicrobial activity composition and methods of preparation |
| KR100872059B1 (ko) * | 2007-02-21 | 2008-12-05 | 주식회사 레고켐 바이오사이언스 | 아미독심 또는 하이드록사마이드 기를 가지는 신규한옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
| KR100870432B1 (ko) | 2007-04-18 | 2008-11-25 | 주식회사 하이닉스반도체 | 트리밍 테스트모드 및 노말 테스트모드를 갖는반도체메모리소자 |
| KR101023174B1 (ko) * | 2008-09-24 | 2011-03-18 | 주식회사 레고켐 바이오사이언스 | 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
| KR101037051B1 (ko) * | 2009-07-08 | 2011-05-26 | 주식회사 레고켐 바이오사이언스 | (ｓ)-5-클로로-ｎ-((3-(4-(5,6-다이하이드로-4ｈ-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법 |
-
2011
- 2011-03-30 KR KR1020110028559A patent/KR101653570B1/ko not_active Expired - Fee Related
-
2012
- 2012-03-29 EP EP18167465.6A patent/EP3372598A1/en not_active Withdrawn
- 2012-03-29 US US14/008,702 patent/US8846669B2/en not_active Expired - Fee Related
- 2012-03-29 MX MX2013011272A patent/MX337409B/es active IP Right Grant
- 2012-03-29 BR BR112013024497-6A patent/BR112013024497A2/pt not_active IP Right Cessation
- 2012-03-29 JP JP2014502469A patent/JP6072764B2/ja not_active Expired - Fee Related
- 2012-03-29 WO PCT/KR2012/002314 patent/WO2012134188A2/ko not_active Ceased
- 2012-03-29 RU RU2013143800A patent/RU2617408C2/ru not_active IP Right Cessation
- 2012-03-29 CA CA2831799A patent/CA2831799A1/en not_active Abandoned
- 2012-03-29 EP EP12764499.5A patent/EP2692727A4/en not_active Ceased
- 2012-03-29 CN CN201280016771.9A patent/CN103476772B/zh not_active Expired - Fee Related
- 2012-03-29 AU AU2012237067A patent/AU2012237067B2/en not_active Ceased
-
2013
- 2013-09-26 ZA ZA2013/07216A patent/ZA201307216B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6072764B2 (ja) | 2017-02-01 |
| CA2831799A1 (en) | 2012-10-04 |
| KR101653570B1 (ko) | 2016-09-02 |
| WO2012134188A2 (ko) | 2012-10-04 |
| JP2014510751A (ja) | 2014-05-01 |
| EP2692727A4 (en) | 2014-10-15 |
| AU2012237067B2 (en) | 2016-07-28 |
| EP3372598A1 (en) | 2018-09-12 |
| MX337409B (es) | 2016-03-02 |
| US20140179691A1 (en) | 2014-06-26 |
| BR112013024497A2 (pt) | 2018-06-26 |
| ZA201307216B (en) | 2014-12-23 |
| US8846669B2 (en) | 2014-09-30 |
| RU2617408C2 (ru) | 2017-04-25 |
| EP2692727A2 (en) | 2014-02-05 |
| KR20120110600A (ko) | 2012-10-10 |
| RU2013143800A (ru) | 2015-05-10 |
| CN103476772B (zh) | 2016-03-30 |
| WO2012134188A3 (ko) | 2013-01-10 |
| AU2012237067A1 (en) | 2013-10-03 |
| CN103476772A (zh) | 2013-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |