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MX2013010012A - Analogos de octreotato radiomarcado como trazadores de tomografia por emision de positrones. - Google Patents

Analogos de octreotato radiomarcado como trazadores de tomografia por emision de positrones.

Info

Publication number
MX2013010012A
MX2013010012A MX2013010012A MX2013010012A MX2013010012A MX 2013010012 A MX2013010012 A MX 2013010012A MX 2013010012 A MX2013010012 A MX 2013010012A MX 2013010012 A MX2013010012 A MX 2013010012A MX 2013010012 A MX2013010012 A MX 2013010012A
Authority
MX
Mexico
Prior art keywords
novel
radiolabelled
pet
pet tracers
radiotracer
Prior art date
Application number
MX2013010012A
Other languages
English (en)
Inventor
Sajinder Kaur Luthra
Julius Leyton
Eric Ofori Aboagye
Lisa Iddon
Bard Indrevoll
Matthias Eberhard Glaser
Alan Cutherbertson
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2013010012A publication Critical patent/MX2013010012A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nuclear Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen trazadores radioactivos novedosos para la imagenología de Tomografía por Emisión de Positrones (PET). Se describen trazadores radioactivos novedosos para la imagenología de Tomografía por Emisión de Positrones (PET) de tumores neuroendocrinos. Específicamente, la presente invención describe análogos novedosos de [18F][fluoroetiltriazol-[Tyr3]octreotato; en particular, aquellos que se enfocan en receptores de somatostatina encontrados en la superficie de células de tumores neuroendocrinos gastroenteropancreáticos. La presente invención también describe intermediarios, precursores, composiciones farmacéuticas, métodos de elaboración, y métodos de uso de los trazadores radioactivos novedosos.
MX2013010012A 2011-03-01 2012-03-01 Analogos de octreotato radiomarcado como trazadores de tomografia por emision de positrones. MX2013010012A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161447785P 2011-03-01 2011-03-01
PCT/US2012/027168 WO2012118909A1 (en) 2011-03-01 2012-03-01 Radiolabelled octreotate analogues as pet tracers

Publications (1)

Publication Number Publication Date
MX2013010012A true MX2013010012A (es) 2014-04-14

Family

ID=45841639

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010012A MX2013010012A (es) 2011-03-01 2012-03-01 Analogos de octreotato radiomarcado como trazadores de tomografia por emision de positrones.

Country Status (11)

Country Link
US (1) US10201625B2 (es)
EP (1) EP2680889B1 (es)
JP (1) JP2014515729A (es)
KR (1) KR20140010096A (es)
CN (1) CN103687627A (es)
AU (1) AU2012223364A1 (es)
CA (1) CA2828810A1 (es)
ES (1) ES2749640T3 (es)
MX (1) MX2013010012A (es)
RU (1) RU2013140291A (es)
WO (1) WO2012118909A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10150804B2 (en) 2014-01-03 2018-12-11 British Columbia Cancer Agency Branch Compositions and methods for imaging cancer
US9988336B2 (en) 2014-03-18 2018-06-05 Mayo Foundation For Medical Education And Research Gaseous F-18 technologies
KR102062025B1 (ko) * 2014-06-30 2020-01-03 타베다 세라퓨틱스, 인코포레이티드 표적화된 콘주게이트 및 입자 및 그것의 제형
CN106084005B (zh) * 2016-06-15 2020-02-14 广州军区广州总医院 靶向生长抑素受体的Al18F-NOTA-PEG6-TATE及其制备方法和应用
US20180296707A1 (en) * 2017-04-12 2018-10-18 SeeCure Taiwan Co., Ltd. Pharmaceutical formulation and method of preparing the same
WO2019126497A1 (en) * 2017-12-22 2019-06-27 Cornell University 18f-labeled peptide ligands useful in pet and cerenkov luminescene imaging
US11992537B2 (en) 2018-05-23 2024-05-28 Provincial Health Services Authority Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy
CN113825530B (zh) 2018-12-18 2024-08-06 省卫生服务机构 双模式18f-标记的热化合物及其用途
US11396535B2 (en) 2019-03-01 2022-07-26 Provincial Health Services Authority Cyclic peptide analogs of melanocortin and amanitin and methods of making such
CA3136979A1 (en) 2019-04-17 2020-10-22 Provincial Health Services Authority Radiolabelled compounds for diagnosis or treatment of prostate-spe cific membrane antigen-expressing cancer
CN114401947B (zh) 2019-06-21 2024-11-29 省卫生服务机构 靶向前列腺特异性膜抗原的放射性标记化合物
CN110407899B (zh) * 2019-07-31 2023-03-31 上海应用技术大学 一种双点击化学联用合成可运用于后聚合改性的含糖衍生物的方法
CN110563809A (zh) * 2019-10-10 2019-12-13 应连心 一种聚乙二醇修饰的奥曲肽及其制备方法
KR20220132556A (ko) * 2020-01-29 2022-09-30 유니버시티 오브 아이오와 리써치 파운데이션 암에 대한 펩티드 수용체 표적화 방사성핵종 치료의 테라노스틱 성능을 개선하기 위한 구조 최적화 방법
CN112587679B (zh) * 2020-12-02 2022-06-17 北京肿瘤医院(北京大学肿瘤医院) 放射性核素标记生长抑素受体拮抗剂及其制备方法和应用
EP4406979B1 (en) * 2021-10-15 2025-11-12 Denka Company Limited Compound and production method for compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432288A (en) * 1991-04-18 1995-07-11 Indiana University Foundation Derivatives of ryanodine and dehydroryanodine
EP1385556A4 (en) * 2001-05-02 2005-10-19 Univ Missouri System At Columb PEPTIDE CONJUGATES WITH AFFINITY FOR GASTRIN RECEPTORS
GB0428012D0 (en) 2004-12-22 2005-01-26 Hammersmith Imanet Ltd Radiolabelling methods
US8309054B2 (en) 2006-08-03 2012-11-13 Hammersmith Imanet Limited Method for the purification of radiolabelled compounds
NZ581160A (en) 2007-05-16 2012-05-25 Ge Healthcare As Labelled hgf binding peptides for imaging
GB0808833D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression
CA2735970A1 (en) 2008-09-05 2010-03-11 Hammersmith Imanet Limited Isatin derivatives for use as in vivo imaging agents

Also Published As

Publication number Publication date
RU2013140291A (ru) 2015-04-10
EP2680889A1 (en) 2014-01-08
KR20140010096A (ko) 2014-01-23
WO2012118909A1 (en) 2012-09-07
US10201625B2 (en) 2019-02-12
CN103687627A (zh) 2014-03-26
ES2749640T3 (es) 2020-03-23
JP2014515729A (ja) 2014-07-03
US20130343990A1 (en) 2013-12-26
AU2012223364A1 (en) 2013-09-19
CA2828810A1 (en) 2012-09-07
EP2680889B1 (en) 2019-06-19

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