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MX2013008164A - Proceso para hacer inhibidores de girasa y topoisomerasa iv. - Google Patents

Proceso para hacer inhibidores de girasa y topoisomerasa iv.

Info

Publication number
MX2013008164A
MX2013008164A MX2013008164A MX2013008164A MX2013008164A MX 2013008164 A MX2013008164 A MX 2013008164A MX 2013008164 A MX2013008164 A MX 2013008164A MX 2013008164 A MX2013008164 A MX 2013008164A MX 2013008164 A MX2013008164 A MX 2013008164A
Authority
MX
Mexico
Prior art keywords
compounds
gyrase
topoisomerase
inhibitors
making
Prior art date
Application number
MX2013008164A
Other languages
English (en)
Other versions
MX355561B (es
Inventor
Tiansheng Wang
Simon Giroux
Dean Shannon
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2013008164A publication Critical patent/MX2013008164A/es
Publication of MX355561B publication Critical patent/MX355561B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente solicitud se dirige a compuestos, intermediarios y métodos para preparar compuestos de la fórmula (I) (Ver Formula) o las sales farmacéuticamente aceptables de los mismos, en donde R es H o F, y cada uno de R3, R4, y R5 son como se definen en la presente. Los compuestos de la fórmula (I) y composiciones farmacéuticas que comprenden los compuestos y las sales inhiben la girasa y/o Topo IV bacteriana y son útiles al tratar infecciones bacterianas.
MX2013008164A 2011-01-14 2012-01-13 Proceso para hacer inhibidores de girasa y topoisomerasa iv. MX355561B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161432990P 2011-01-14 2011-01-14
PCT/US2012/021281 WO2012097274A1 (en) 2011-01-14 2012-01-13 Process of making gyrase and topoisomerase iv inhibitors

Publications (2)

Publication Number Publication Date
MX2013008164A true MX2013008164A (es) 2013-08-27
MX355561B MX355561B (es) 2018-04-23

Family

ID=45815947

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008164A MX355561B (es) 2011-01-14 2012-01-13 Proceso para hacer inhibidores de girasa y topoisomerasa iv.

Country Status (19)

Country Link
US (2) US8471014B2 (es)
EP (1) EP2663556B1 (es)
JP (1) JP6006235B2 (es)
KR (1) KR101882172B1 (es)
CN (1) CN103384665B (es)
AR (1) AR084864A1 (es)
AU (1) AU2012205420B2 (es)
BR (1) BR112013017968B1 (es)
CA (1) CA2824519C (es)
ES (1) ES2526902T3 (es)
IL (1) IL227405B (es)
MX (1) MX355561B (es)
NZ (1) NZ612920A (es)
PT (1) PT2663556E (es)
RU (1) RU2619116C2 (es)
SG (1) SG191945A1 (es)
TW (1) TWI534143B (es)
WO (1) WO2012097274A1 (es)
ZA (1) ZA201305232B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX339455B (es) * 2011-01-14 2016-05-27 Vertex Pharma Inhibidores de pirimidina y topoisomerasa iv.
CN103403000B (zh) * 2011-01-14 2017-05-31 斯派罗吹耐姆公司 固体形式的促旋酶抑制剂（r）‑1‑乙基‑3‑[6‑氟‑5‑[2‑（1‑羟基‑1‑甲基‑乙基）嘧啶‑5‑基]‑7‑（四氢呋喃‑2‑基）‑1氢‑苯并咪唑‑2‑基]脲
RU2619116C2 (ru) 2011-01-14 2017-05-12 Сперо Тринем, Инк. Способ получения ингибиторов гиразы и топоизомеразы iv
MX351555B (es) * 2011-01-14 2017-10-19 Spero Trinem Inc Formas solidas de inhibidor de girasa (r)-1-etil-3-[5-[2-(1-hidrox i-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1h-benzim idazol-2-il]urea.
US9125922B2 (en) * 2011-06-20 2015-09-08 Vertex Pharmaceuticals Incorporated Phosphate esters of gyrase and topoisomerase inhibitors
AR093226A1 (es) * 2012-07-18 2015-05-27 Vertex Pharma Formas solidas de dihidrogeno fosfato de (r)-2-(5-(2-(3-etilureido)-6-fluoro-7-(tetrahidrofuran-2-il)-1h-benzo[d]imidazol-5-il)pirimidin-2-il)propan-2-ilo y sus sales
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
KR20160115986A (ko) 2014-02-03 2016-10-06 스페로 자이레이스, 인크 폴리믹신을 포함하는 항균성 조합

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DE2015676A1 (de) 1970-04-02 1971-10-21 Farbenfabriken Bayer Ag, 5090 Leverkusen Neue Imine der 2-Formyl-chinoxalindi-N-oxidcarbon-säure-(3) und deren Salze, Verfahren zu ihrer Herstellung und ihre Verwendung als antimikrobielle Mittel
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DE19514313A1 (de) 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
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TW538046B (en) 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
AUPP873799A0 (en) 1999-02-17 1999-03-11 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds
GB9911594D0 (en) 1999-05-19 1999-07-21 Smithkline Beecham Plc Novel compounds
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
EP1341769B1 (en) 2000-12-15 2007-10-17 Vertex Pharmaceuticals Incorporated Bacterial gyrase inhibitors and uses thereof
AU2003245442B2 (en) * 2002-06-13 2009-02-05 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase IV inhibitors for the treatment of bacterial infections
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
BRPI0407519A (pt) * 2003-03-07 2006-02-14 Kowa Co derivados de benzofurano
AU2006311729A1 (en) * 2005-11-07 2007-05-18 Vertex Pharmaceuticals Incorporated Benzimidazole derivatives as gyrase inhibitors
GB0724349D0 (en) 2007-12-13 2008-01-30 Prolysis Ltd Antibacterial agents
GB0612428D0 (en) 2006-06-22 2006-08-02 Prolysis Ltd Antibacterial agents
US8481544B2 (en) 2006-06-22 2013-07-09 Biota Europe Limited Antibacterial compositions
UA96964C2 (ru) 2006-12-04 2011-12-26 Астразенека Аб Соединения полициклической мочевины с антибактериальными свойствами
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RU2619116C2 (ru) 2011-01-14 2017-05-12 Сперо Тринем, Инк. Способ получения ингибиторов гиразы и топоизомеразы iv
MX339455B (es) * 2011-01-14 2016-05-27 Vertex Pharma Inhibidores de pirimidina y topoisomerasa iv.
CN103403000B (zh) 2011-01-14 2017-05-31 斯派罗吹耐姆公司 固体形式的促旋酶抑制剂（r）‑1‑乙基‑3‑[6‑氟‑5‑[2‑（1‑羟基‑1‑甲基‑乙基）嘧啶‑5‑基]‑7‑（四氢呋喃‑2‑基）‑1氢‑苯并咪唑‑2‑基]脲
MX351555B (es) * 2011-01-14 2017-10-19 Spero Trinem Inc Formas solidas de inhibidor de girasa (r)-1-etil-3-[5-[2-(1-hidrox i-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1h-benzim idazol-2-il]urea.
US9125922B2 (en) * 2011-06-20 2015-09-08 Vertex Pharmaceuticals Incorporated Phosphate esters of gyrase and topoisomerase inhibitors
US8906902B2 (en) 2012-03-22 2014-12-09 Biota Europe Limited Antibacterial compounds
AR093226A1 (es) * 2012-07-18 2015-05-27 Vertex Pharma Formas solidas de dihidrogeno fosfato de (r)-2-(5-(2-(3-etilureido)-6-fluoro-7-(tetrahidrofuran-2-il)-1h-benzo[d]imidazol-5-il)pirimidin-2-il)propan-2-ilo y sus sales
US9572809B2 (en) * 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases

Also Published As

Publication number Publication date
ES2526902T3 (es) 2015-01-16
EP2663556B1 (en) 2014-10-15
SG191945A1 (en) 2013-08-30
AU2012205420B2 (en) 2016-12-08
KR20140037028A (ko) 2014-03-26
ZA201305232B (en) 2014-11-26
US8471014B2 (en) 2013-06-25
CN103384665B (zh) 2018-01-09
BR112013017968B1 (pt) 2021-03-16
AU2012205420A1 (en) 2013-08-01
CN103384665A (zh) 2013-11-06
TWI534143B (zh) 2016-05-21
KR101882172B1 (ko) 2018-07-26
US20130261305A1 (en) 2013-10-03
JP2014503558A (ja) 2014-02-13
CA2824519A1 (en) 2012-07-19
BR112013017968A2 (pt) 2016-07-12
RU2619116C2 (ru) 2017-05-12
EP2663556A1 (en) 2013-11-20
US8912326B2 (en) 2014-12-16
TW201307332A (zh) 2013-02-16
IL227405B (en) 2018-05-31
IL227405A0 (en) 2013-09-30
JP6006235B2 (ja) 2016-10-12
NZ612920A (en) 2015-10-30
RU2013137751A (ru) 2015-02-20
MX355561B (es) 2018-04-23
PT2663556E (pt) 2014-11-27
CA2824519C (en) 2020-06-16
WO2012097274A1 (en) 2012-07-19
AR084864A1 (es) 2013-07-10
US20120184742A1 (en) 2012-07-19

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Legal Events

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Owner name: SPERO TRINEM, INC.

FG Grant or registration