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MX2013007166A - 5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo [1,2-a][1,4]benzodiazepinas antimicoticas novedosas sustituidas con derivados de benceno biciclicos. - Google Patents

5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo [1,2-a][1,4]benzodiazepinas antimicoticas novedosas sustituidas con derivados de benceno biciclicos.

Info

Publication number
MX2013007166A
MX2013007166A MX2013007166A MX2013007166A MX2013007166A MX 2013007166 A MX2013007166 A MX 2013007166A MX 2013007166 A MX2013007166 A MX 2013007166A MX 2013007166 A MX2013007166 A MX 2013007166A MX 2013007166 A MX2013007166 A MX 2013007166A
Authority
MX
Mexico
Prior art keywords
benzodiazepins
pirrolo
benzene derivatives
novedous
antimicotic
Prior art date
Application number
MX2013007166A
Other languages
English (en)
Inventor
Lieven Meerpoel
Louis Jules Roger Marie Maes
Wit Kelly De
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2013007166A publication Critical patent/MX2013007166A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a 5,6-dihidro-4H-pirrolo-[1,2- a][1,4]benzodiazepinas y 6H-pirrolo[1,2-a][ 1 ,4]benzodiazepinas sustituidas antimicóticas novedosas con derivados de benceno bicíclicos de la fórmula (1) (Ver formula) en donde R1, R2, R3, R4, R5, R6 y R7 tienen el significado definido en las reivindicaciones; los compuestos de conformidad con la presente invención son activos principalmente contra dermatofitos e infecciones micóticas sistémicas; la invención además se refiere a procedimientos para preparar dichos compuestos novedosos, composiciones farmacéuticas que comprenden dichos compuestos como un ingrediente activo así como el uso de dichos compuestos como un medicamento.
MX2013007166A 2010-12-21 2011-12-19 5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo [1,2-a][1,4]benzodiazepinas antimicoticas novedosas sustituidas con derivados de benceno biciclicos. MX2013007166A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10196201 2010-12-21
PCT/EP2011/073215 WO2012084804A1 (en) 2010-12-21 2011-12-19 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]- BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES

Publications (1)

Publication Number Publication Date
MX2013007166A true MX2013007166A (es) 2013-08-01

Family

ID=43608264

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007166A MX2013007166A (es) 2010-12-21 2011-12-19 5,6-dihidro-4h-pirrolo[1,2-a][1,4]-benzodiazepinas y 6h-pirrolo [1,2-a][1,4]benzodiazepinas antimicoticas novedosas sustituidas con derivados de benceno biciclicos.

Country Status (20)

Country Link
US (1) US9040524B2 (es)
EP (1) EP2668187B1 (es)
JP (1) JP5918258B2 (es)
KR (1) KR101839365B1 (es)
CN (1) CN103282367B (es)
AP (1) AP4012A (es)
AU (1) AU2011347577B2 (es)
BR (1) BR112013016007A2 (es)
CA (1) CA2818623C (es)
EA (1) EA022407B1 (es)
ES (1) ES2527032T3 (es)
IL (1) IL227053A (es)
MX (1) MX2013007166A (es)
MY (1) MY161360A (es)
NZ (1) NZ610939A (es)
PH (1) PH12013501126A1 (es)
SG (1) SG190971A1 (es)
UA (1) UA109796C2 (es)
WO (1) WO2012084804A1 (es)
ZA (1) ZA201304577B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013012547A2 (pt) * 2010-11-24 2016-08-09 Janssen Pharmaceutica Nv antifúngicos 5,6-di-hidro-4h-pirrolo][1,4]benzodiazepinas e 6h-pirrolo [1,2-a] [1,4]benzodiazepinas substituídos por derivados de fenila
IL293645A (en) 2017-01-25 2022-08-01 Immunogen Inc Methods for preparing cytotoxic benzodiazepine derivatives
KR102652866B1 (ko) 2017-04-06 2024-04-02 엥방티바 Ｙａｐ/ｔａｚ-ｔｅａｄ 상호작용의 억제제인 신규 화합물 및 악성 중피종의 치료에서의 이들의 용도
CN110418791B (zh) * 2017-04-28 2022-07-01 四川科伦博泰生物医药股份有限公司 包含苯并二氮䓬类化合物的注射用组合物及其制备方法
EP3632908A1 (en) 2018-10-02 2020-04-08 Inventiva Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer
WO2024102999A2 (en) * 2022-11-11 2024-05-16 Ohio State Innovation Foundation Small molecule inhibitors for the treatment and prevention of coronavirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1392691T1 (sl) * 2000-10-23 2009-10-31 Janssen Pharmaceutica Nv Protiglivični 4-substituirani 5,6-dihidro-4H-pirolo(1,2-A)(1,4)benzodiazepini
JP2009532449A (ja) * 2006-04-05 2009-09-10 アストラゼネカ アクチボラグ 抗癌活性のある置換キナゾリン
WO2009086303A2 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
BR112013012547A2 (pt) * 2010-11-24 2016-08-09 Janssen Pharmaceutica Nv antifúngicos 5,6-di-hidro-4h-pirrolo][1,4]benzodiazepinas e 6h-pirrolo [1,2-a] [1,4]benzodiazepinas substituídos por derivados de fenila

Also Published As

Publication number Publication date
CN103282367A (zh) 2013-09-04
UA109796C2 (xx) 2015-10-12
US9040524B2 (en) 2015-05-26
EP2668187A1 (en) 2013-12-04
EA201390921A1 (ru) 2013-11-29
NZ610939A (en) 2014-07-25
BR112013016007A2 (pt) 2018-07-10
CA2818623C (en) 2019-03-12
AP4012A (en) 2017-01-22
KR101839365B1 (ko) 2018-03-16
US20130267507A1 (en) 2013-10-10
CA2818623A1 (en) 2012-06-28
HK1188792A1 (zh) 2014-05-16
PH12013501126A1 (en) 2022-03-30
JP2014500288A (ja) 2014-01-09
EA022407B1 (ru) 2015-12-30
EP2668187B1 (en) 2014-10-15
IL227053A (en) 2015-10-29
ES2527032T3 (es) 2015-01-19
ZA201304577B (en) 2014-12-23
MY161360A (en) 2017-04-14
CN103282367B (zh) 2015-07-29
KR20140003497A (ko) 2014-01-09
AP2013006886A0 (en) 2013-05-31
JP5918258B2 (ja) 2016-05-18
WO2012084804A1 (en) 2012-06-28
AU2011347577B2 (en) 2016-04-28
SG190971A1 (en) 2013-07-31
AU2011347577A1 (en) 2013-06-13

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