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MX2013006188A - Agentes de generacion de imagenes pet de apoptosis. - Google Patents

Agentes de generacion de imagenes pet de apoptosis.

Info

Publication number
MX2013006188A
MX2013006188A MX2013006188A MX2013006188A MX2013006188A MX 2013006188 A MX2013006188 A MX 2013006188A MX 2013006188 A MX2013006188 A MX 2013006188A MX 2013006188 A MX2013006188 A MX 2013006188A MX 2013006188 A MX2013006188 A MX 2013006188A
Authority
MX
Mexico
Prior art keywords
imaging agents
pet imaging
apoptosis
imaging
vivo
Prior art date
Application number
MX2013006188A
Other languages
English (en)
Inventor
Duncan Hiscock
Bard Indrevoll
Rajiv Bhalla
Bente Elizabeth Arbo
Graeme Walter Mcrobbie
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2013006188A publication Critical patent/MX2013006188A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nuclear Medicine (AREA)

Abstract

La presente invención se refiere a la generación de imágenes radiofarmacéuticas in vivo de apoptosis y otras formas de muerte celular. La presente invención proporciona agentes de generación de imágenes PET que dirigen las células apoptóticas mediante el enlace al aminofosfolípido, fosfatidiletanolamina (PE), que está expuesto en la superficie de células apoptóticas. También se proporcionan composiciones farmacéuticas, equipos y métodos de generación de imágenes in vivo.
MX2013006188A 2010-12-01 2011-12-01 Agentes de generacion de imagenes pet de apoptosis. MX2013006188A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1020314.9A GB201020314D0 (en) 2010-12-01 2010-12-01 Apoptosis pet imaging agents
PCT/EP2011/071484 WO2012072728A1 (en) 2010-12-01 2011-12-01 Apoptosis pet imaging agents

Publications (1)

Publication Number Publication Date
MX2013006188A true MX2013006188A (es) 2013-07-29

Family

ID=43500891

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006188A MX2013006188A (es) 2010-12-01 2011-12-01 Agentes de generacion de imagenes pet de apoptosis.

Country Status (12)

Country Link
US (1) US20130251632A1 (es)
EP (1) EP2646061A1 (es)
JP (1) JP2014505021A (es)
KR (1) KR20130119936A (es)
CN (1) CN103228298A (es)
AU (1) AU2011334966A1 (es)
BR (1) BR112013013285A2 (es)
CA (1) CA2819483A1 (es)
GB (1) GB201020314D0 (es)
MX (1) MX2013006188A (es)
RU (1) RU2013123909A (es)
WO (1) WO2012072728A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201221266D0 (en) * 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201314936D0 (en) * 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
GB201322451D0 (en) * 2013-12-18 2014-02-05 Ge Healthcare Ltd Purification method and compositions
WO2017054907A1 (en) 2015-09-30 2017-04-06 Deutsches Krebsforschungszentrum 18f-tagged inhibitors of prostate specific membrane antigen (psma) and their use as imaging agents for prostate cancer
CN105582556A (zh) * 2016-01-25 2016-05-18 中南大学湘雅医院 一种锝标耐久霉素分子探针
CN108144073A (zh) * 2017-12-28 2018-06-12 中山大学附属第医院 靶向磷脂酰乙醇胺的放射性标记三聚乙二醇修饰耐久霉素多肽药物
GB201804835D0 (en) * 2018-03-26 2018-05-09 Ge Healthcare As Formulation and method of preparation
CN113368264B (zh) * 2020-03-09 2022-09-30 南方医科大学南方医院 放射性标记肉桂霉素，其制备方法及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879801B2 (en) 2002-07-15 2011-02-01 Board Of Regents, The University Of Texas System Compositions comprising cell-impermeant duramycin derivatives
GB0305704D0 (en) * 2003-03-13 2003-04-16 Amersham Plc Radiofluorination methods
WO2006055855A2 (en) 2004-11-19 2006-05-26 Mcw Research Foundation, Inc. Method of imaging cell death in vivo
JP5318874B2 (ja) * 2007-09-10 2013-10-16 ジーイー・ヘルスケア・リミテッド 放射性フッ素化方法
CA2724462A1 (en) 2008-03-10 2009-09-17 Mcw Research Foundation, Inc. 99mtc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical

Also Published As

Publication number Publication date
JP2014505021A (ja) 2014-02-27
RU2013123909A (ru) 2015-01-10
WO2012072728A1 (en) 2012-06-07
AU2011334966A1 (en) 2013-06-06
GB201020314D0 (en) 2011-01-12
KR20130119936A (ko) 2013-11-01
EP2646061A1 (en) 2013-10-09
US20130251632A1 (en) 2013-09-26
CN103228298A (zh) 2013-07-31
BR112013013285A2 (pt) 2016-11-22
CA2819483A1 (en) 2012-06-07

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