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MX2013002591A - Canalrodopsina 2 mutante. - Google Patents

Canalrodopsina 2 mutante.

Info

Publication number
MX2013002591A
MX2013002591A MX2013002591A MX2013002591A MX2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A
Authority
MX
Mexico
Prior art keywords
mutant
nucleic acid
channelrhodopsin
acid construct
channelrhodopsins
Prior art date
Application number
MX2013002591A
Other languages
English (en)
Other versions
MX347453B (es
Inventor
Robert E Dempski
Ernst Bamberg
Christian Bamann
Sonja Kleinlogel
Phillip Wodd
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Publication of MX2013002591A publication Critical patent/MX2013002591A/es
Publication of MX347453B publication Critical patent/MX347453B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La invención se relaciona con canalrodopsinas mutantes que tienen propiedades mejoradas, constructos de ácido nucleico que codifican los mismos, vectores de expresión que portan el constructo de ácido nucleico, células que comprenden el constructo de ácido nucleico o vector de expresión y sus usos respectivos.
MX2013002591A 2010-09-08 2011-09-08 Canalrodopsina 2 mutante. MX347453B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38079310P 2010-09-08 2010-09-08
EP10175832 2010-09-08
PCT/EP2011/065510 WO2012032103A1 (en) 2010-09-08 2011-09-08 Mutant channelrhodopsin 2

Publications (2)

Publication Number Publication Date
MX2013002591A true MX2013002591A (es) 2013-07-22
MX347453B MX347453B (es) 2017-04-27

Family

ID=42979822

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002591A MX347453B (es) 2010-09-08 2011-09-08 Canalrodopsina 2 mutante.

Country Status (20)

Country Link
US (1) US8748578B2 (es)
EP (1) EP2614079B1 (es)
JP (1) JP5933556B2 (es)
KR (1) KR101945962B1 (es)
CN (1) CN103261219B (es)
AU (1) AU2011298745B2 (es)
BR (1) BR112013005634A2 (es)
CA (1) CA2810757C (es)
DK (1) DK2614079T3 (es)
ES (1) ES2545992T3 (es)
HR (1) HRP20150846T1 (es)
HU (1) HUE025952T2 (es)
IL (1) IL225060A (es)
MX (1) MX347453B (es)
PL (1) PL2614079T3 (es)
PT (1) PT2614079E (es)
RU (1) RU2595384C2 (es)
SG (1) SG188409A1 (es)
SI (1) SI2614079T1 (es)
WO (1) WO2012032103A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006284425A1 (en) 2005-07-22 2007-03-01 The Board Of Trustees Of The Leland Stanford Junior University Light-activated cation channel and uses thereof
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US8470790B2 (en) 2006-05-04 2013-06-25 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
US8398692B2 (en) 2007-01-10 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
WO2008101128A1 (en) 2007-02-14 2008-08-21 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
AU2009238467B2 (en) 2008-04-23 2015-06-25 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
EP2610350B1 (en) 2008-05-29 2014-12-17 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
SG191604A1 (en) 2008-06-17 2013-07-31 Univ Leland Stanford Junior Apparatus and methods for controlling cellular development
MX2010014100A (es) 2008-06-17 2011-03-04 Univ Leland Stanford Junior Metodos, sistemas y dispositivos para estimulacion optica de celulas objetivo usando un elemento de transmision optica.
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
CA2791094A1 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The Leland Stanford Junior University Light-sensitive ion-passing molecules
WO2011140279A1 (en) 2010-05-04 2011-11-10 Wayne State University Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
EP2635111B1 (en) * 2010-11-05 2018-05-23 The Board of Trustees of the Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
CN106947741A (zh) 2010-11-05 2017-07-14 斯坦福大学托管董事会 光活化嵌合视蛋白及其使用方法
AU2011323237B2 (en) 2010-11-05 2015-11-12 The Board Of Trustees Of The Leland Stanford Junior University Optically-controlled CNS dysfunction
JP6145043B2 (ja) 2010-11-05 2017-06-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 光遺伝的方法で使用するための光の上方変換
JP6328424B6 (ja) 2010-11-05 2018-07-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 記憶機能の制御および特性化
CN103476456B (zh) 2010-11-05 2017-10-03 斯坦福大学托管董事会 奖赏相关行为的光遗传学控制
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CN104093833B (zh) 2011-12-16 2017-11-07 斯坦福大学托管董事会 视蛋白多肽及其使用方法
AU2013222443B2 (en) 2012-02-21 2017-12-14 Circuit Therapeutics, Inc. Compositions and methods for treating neurogenic disorders of the pelvic floor
US10947281B2 (en) * 2012-03-05 2021-03-16 Wayne State University Identification of channelrhodopsin-2 (ChR2) mutations and methods of use
EP2968997B1 (en) 2013-03-15 2019-06-26 The Board of Trustees of the Leland Stanford Junior University Optogenetic control of behavioral state
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
US10220092B2 (en) 2013-04-29 2019-03-05 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
CA2921221A1 (en) 2013-08-14 2015-02-19 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for controlling pain
JP6118239B2 (ja) 2013-11-29 2017-04-19 雅敏 堀 害虫の防除方法及び防除装置
US10392426B2 (en) 2014-02-07 2019-08-27 Massachusetts Institute Of Technology Blue-light-activated ion channel polypeptides and uses thereof
WO2015142984A1 (en) * 2014-03-18 2015-09-24 Washington University Methods and compositions for red-shifted chromophore substitution for optogenetic applications
US10590181B2 (en) 2014-04-18 2020-03-17 Massachusetts Institute Of Technology Mutant channelrhodopsins with altered ion selectivity
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
KR102471929B1 (ko) * 2016-06-03 2022-11-28 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 크림슨의 돌연변이 광-유도성 이온 채널
KR20190020702A (ko) * 2016-06-03 2019-03-04 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 채널로돕신의 돌연변이 광-유도성 이온 채널
KR20250159068A (ko) 2016-08-29 2025-11-07 웨인 스테이트 유니버시티 개선된 광 민감성을 갖는 채널옵신 변이체에서의 돌연변이의 확인 및 이의 용도
US11180537B2 (en) 2016-11-06 2021-11-23 Nancoscope Technologies LLC Optogenetic modulation by Multi-Characteristic Opsins for vision restoration and other applications
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
JP2020516295A (ja) * 2017-04-12 2020-06-11 マックス−プランク−ゲゼルシャフト ツア フェルデルンク デア ヴィッセンシャフテン エー．ファウ． 新規光遺伝学ツール
CN110483645B (zh) * 2018-05-14 2023-05-12 郑州大学第一附属医院 线粒体定位质子泵型视紫红质、其突变蛋白及其应用
GB2586751B (en) 2018-07-26 2022-12-07 Council Scient Ind Res Screening kit for detection of grades of cervical cancer and process for the preparation thereof
CN112689675B (zh) * 2018-09-14 2023-09-19 国立大学法人名古屋工业大学 光响应性蛋白及其应用
US20230104240A1 (en) * 2020-03-13 2023-04-06 Nagoya Institute Of Technology Photoresponsive protein for color recognition and use thereof
WO2022176754A1 (ja) * 2021-02-18 2022-08-25 国立大学法人名古屋工業大学 青色光もしくは藍色光応答性タンパク質及びその利用
EP4223768A1 (en) 2022-02-04 2023-08-09 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel
WO2024092248A1 (en) * 2022-10-28 2024-05-02 The Board Of Trustees Of The Leland Stanford Junior University Enhanced light gated potassium selective channelrhodopsin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2112501A1 (de) 1998-02-05 2009-10-28 Novartis Ag Verfahren und Vorrichtung zur Lumineszenzmessung
DE10216005A1 (de) 2002-04-11 2003-10-30 Max Planck Gesellschaft Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
US8470790B2 (en) * 2006-05-04 2013-06-25 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
DE102008020152B4 (de) * 2008-04-22 2012-04-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
NZ602416A (en) * 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto

Also Published As

Publication number Publication date
JP5933556B2 (ja) 2016-06-15
BR112013005634A2 (pt) 2017-06-27
CN103261219B (zh) 2017-05-17
HUE025952T2 (en) 2016-04-28
ES2545992T3 (es) 2015-09-17
SG188409A1 (en) 2013-04-30
CA2810757A1 (en) 2012-03-15
KR101945962B1 (ko) 2019-02-08
US8748578B2 (en) 2014-06-10
SI2614079T1 (sl) 2015-10-30
WO2012032103A1 (en) 2012-03-15
KR20130108335A (ko) 2013-10-02
HRP20150846T1 (hr) 2015-09-11
IL225060A (en) 2016-10-31
EP2614079A1 (en) 2013-07-17
PL2614079T3 (pl) 2016-01-29
PT2614079E (pt) 2015-10-06
JP2013544494A (ja) 2013-12-19
EP2614079B1 (en) 2015-07-15
CA2810757C (en) 2020-06-09
DK2614079T3 (en) 2015-08-10
US20130281379A1 (en) 2013-10-24
AU2011298745A1 (en) 2013-03-21
CN103261219A (zh) 2013-08-21
RU2013115454A (ru) 2014-10-20
AU2011298745B2 (en) 2015-05-07
RU2595384C2 (ru) 2016-08-27
MX347453B (es) 2017-04-27

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