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MX2013002358A - Compuestos y composiciones de guanidina para la inhibicion de nampt. - Google Patents

Compuestos y composiciones de guanidina para la inhibicion de nampt.

Info

Publication number
MX2013002358A
MX2013002358A MX2013002358A MX2013002358A MX2013002358A MX 2013002358 A MX2013002358 A MX 2013002358A MX 2013002358 A MX2013002358 A MX 2013002358A MX 2013002358 A MX2013002358 A MX 2013002358A MX 2013002358 A MX2013002358 A MX 2013002358A
Authority
MX
Mexico
Prior art keywords
nampt
inhibition
compositions
guanidine compounds
compounds
Prior art date
Application number
MX2013002358A
Other languages
English (en)
Other versions
MX342838B (es
Inventor
Jian Lin
Alexandre J Buckmelter
Kenneth W Bair
Bingsong Han
Dominic J Reynolds
Chase C Smith
Zhongguo Wang
Xiaozhang Zheng
Original Assignee
Forma Tm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Tm Llc filed Critical Forma Tm Llc
Publication of MX2013002358A publication Critical patent/MX2013002358A/es
Publication of MX342838B publication Critical patent/MX342838B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a compuestos y composiciones para la inhibición de NAMPT, sus síntesis, aplicaciones y antídotos. A continuación se muestra un compuesto ilustrativo de la invención: (ver Fórmula (I)).
MX2013002358A 2010-09-03 2011-09-02 Compuestos y composiciones de guanidina para la inhibicion de nampt. MX342838B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37980010P 2010-09-03 2010-09-03
US38603310P 2010-09-24 2010-09-24
US201161476590P 2011-04-18 2011-04-18
PCT/US2011/050323 WO2012031199A1 (en) 2010-09-03 2011-09-02 Guanidine compounds and compositions for the inhibition of nampt

Publications (2)

Publication Number Publication Date
MX2013002358A true MX2013002358A (es) 2013-08-01
MX342838B MX342838B (es) 2016-10-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002358A MX342838B (es) 2010-09-03 2011-09-02 Compuestos y composiciones de guanidina para la inhibicion de nampt.

Country Status (13)

Country Link
US (1) US9676721B2 (es)
EP (1) EP2611778B1 (es)
JP (1) JP5881705B2 (es)
KR (1) KR20140020823A (es)
CN (2) CN106243023A (es)
AR (1) AR082886A1 (es)
AU (1) AU2011295727B2 (es)
BR (1) BR112013005108A2 (es)
CA (1) CA2810049A1 (es)
MX (1) MX342838B (es)
RU (1) RU2593759C2 (es)
TW (1) TW201216963A (es)
WO (1) WO2012031199A1 (es)

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SG188367A1 (en) 2010-09-03 2013-04-30 Forma Tm Llc Novel compounds and compositions for the inhibition of nampt
JP6038792B2 (ja) 2010-09-03 2016-12-07 フォーマ ティーエム， エルエルシー． 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体
AU2011329233A1 (en) 2010-11-15 2013-05-23 Abbvie Deutschland Gmbh & Co Kg NAMPT and ROCK inhibitors
IN2013MN02014A (es) 2011-05-09 2015-06-12 Forma Tm Llc
SG11201405056UA (en) 2012-03-02 2014-09-26 Genentech Inc Amido spirocyclic amide and sulfonamide derivatives
SG10201701894SA (en) 2012-03-02 2017-05-30 Genentech Inc Amido-Benzyl Sulfone and Sulfoxide Derivatives
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
WO2013170115A1 (en) 2012-05-11 2013-11-14 Abbvie Inc. Pyridazine and pyridine derivatives as nampt inhibitors
WO2014074715A1 (en) * 2012-11-07 2014-05-15 Genentech, Inc. Cyclopropyl amide derivatives
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