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MX2013001234A - Derivados deuterados de tandospirona como agonistas del receptor 5-hidroxitriptamina 1a. - Google Patents

Derivados deuterados de tandospirona como agonistas del receptor 5-hidroxitriptamina 1a.

Info

Publication number
MX2013001234A
MX2013001234A MX2013001234A MX2013001234A MX2013001234A MX 2013001234 A MX2013001234 A MX 2013001234A MX 2013001234 A MX2013001234 A MX 2013001234A MX 2013001234 A MX2013001234 A MX 2013001234A MX 2013001234 A MX2013001234 A MX 2013001234A
Authority
MX
Mexico
Prior art keywords
receptor agonists
derivatives
tandospirone
deuterated
ht1a receptor
Prior art date
Application number
MX2013001234A
Other languages
English (en)
Inventor
John Bondo Hansen
Mikael Soendergaard Thomsen
Original Assignee
Conrig Pharma Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conrig Pharma Aps filed Critical Conrig Pharma Aps
Publication of MX2013001234A publication Critical patent/MX2013001234A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a nuevos derivados de los agonistas del receptor 5-HIT1A de serotonina de la Fórmula I y en particular a composiciones y métodos para uso terapéutico.
MX2013001234A 2010-08-05 2011-08-04 Derivados deuterados de tandospirona como agonistas del receptor 5-hidroxitriptamina 1a. MX2013001234A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201070349 2010-08-05
PCT/DK2011/050302 WO2012016569A1 (en) 2010-08-05 2011-08-04 Deuterated tandospirone derivatives as 5-ht1a receptor agonists

Publications (1)

Publication Number Publication Date
MX2013001234A true MX2013001234A (es) 2013-04-24

Family

ID=44512475

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001234A MX2013001234A (es) 2010-08-05 2011-08-04 Derivados deuterados de tandospirona como agonistas del receptor 5-hidroxitriptamina 1a.

Country Status (5)

Country Link
US (1) US20130303497A1 (es)
EP (1) EP2601187A1 (es)
BR (1) BR112013002846A2 (es)
MX (1) MX2013001234A (es)
WO (1) WO2012016569A1 (es)

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US9409899B2 (en) 2012-02-13 2016-08-09 Cadila Healthcare Limited Process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexylmethanisoindol-1,3-dione and its intermediates
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
JP6539274B2 (ja) 2013-08-12 2019-07-03 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド 押出成形された即放性乱用抑止性丸剤
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2016010771A1 (en) 2014-07-17 2016-01-21 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
JP2017531026A (ja) 2014-10-20 2017-10-19 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド 徐放性乱用抑止性液体充填剤形
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
IT201900000657A1 (it) 2019-01-16 2020-07-16 Procos Spa Processo per la sintesi di gepirone
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
CN116283926B (zh) * 2021-12-20 2025-02-25 重庆圣华曦药业股份有限公司 枸橼酸坦度螺酮的制备方法及其在制剂中的应用
CA3254546A1 (en) 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. COMPOSITIONS CONTAINING ATICAPRANT
KR20240156409A (ko) 2022-03-07 2024-10-29 얀센 파마슈티칼즈, 인코포레이티드 주요 우울 장애 치료에 사용을 위한 아티카프란트의 다형 형태

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4356108A (en) 1979-12-20 1982-10-26 The Mead Corporation Encapsulation process
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4507303A (en) 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US5011841B1 (en) * 1989-11-14 1994-09-06 Pfizer Treatment of depression
US5330762A (en) 1992-02-27 1994-07-19 Alza Corporation Tandospiaine antidepressive therapy
JP2002020291A (ja) 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd 認知機能障害の治療剤
JP2003335678A (ja) 2002-05-17 2003-11-25 Sumitomo Pharmaceut Co Ltd 神経因性疼痛治療薬
US20040002500A1 (en) 2002-06-28 2004-01-01 Fabre Kramer Pharmaceutical, Inc. Methods for treating attention deficit disorder
JP4677191B2 (ja) 2004-02-16 2011-04-27 あすか製薬株式会社 過敏性腸症候群処置剤
US20070232629A1 (en) 2004-06-01 2007-10-04 Toshiro Yamaguchi Adhesive Patch
JP5243254B2 (ja) 2006-10-11 2013-07-24 久光製薬株式会社 結晶含有貼付剤
TW201023912A (en) 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension

Also Published As

Publication number Publication date
WO2012016569A1 (en) 2012-02-09
US20130303497A1 (en) 2013-11-14
BR112013002846A2 (pt) 2016-06-07
EP2601187A1 (en) 2013-06-12

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Legal Events

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