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MX2013000733A - Composiciones de noribogaina. - Google Patents

Composiciones de noribogaina.

Info

Publication number
MX2013000733A
MX2013000733A MX2013000733A MX2013000733A MX2013000733A MX 2013000733 A MX2013000733 A MX 2013000733A MX 2013000733 A MX2013000733 A MX 2013000733A MX 2013000733 A MX2013000733 A MX 2013000733A MX 2013000733 A MX2013000733 A MX 2013000733A
Authority
MX
Mexico
Prior art keywords
noribogaine
compositions
noribogaine compositions
enantiomer
disclosed
Prior art date
Application number
MX2013000733A
Other languages
English (en)
Inventor
Robert M Moriarty
Deborah C Mash
Original Assignee
Demerx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Demerx Inc filed Critical Demerx Inc
Publication of MX2013000733A publication Critical patent/MX2013000733A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se dan a conocer composiciones de noribogaína que comprenden un nivel muy alto del enantiómero 2(R), 4(S), 5(S), 6(S) y 18(R) y no más de 0.5% en peso de ibogaína en relación con la cantidad total de noribogaína.
MX2013000733A 2010-07-23 2011-07-22 Composiciones de noribogaina. MX2013000733A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36731010P 2010-07-23 2010-07-23
US41976610P 2010-12-03 2010-12-03
PCT/US2011/045081 WO2012012764A1 (en) 2010-07-23 2011-07-22 Noribogaine compositions

Publications (1)

Publication Number Publication Date
MX2013000733A true MX2013000733A (es) 2013-05-30

Family

ID=44558453

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000733A MX2013000733A (es) 2010-07-23 2011-07-22 Composiciones de noribogaina.

Country Status (9)

Country Link
US (3) US9358237B2 (es)
EP (1) EP2595632A1 (es)
JP (2) JP6049615B2 (es)
CN (1) CN103079571A (es)
CA (1) CA2806232A1 (es)
MX (1) MX2013000733A (es)
RU (1) RU2586296C2 (es)
UA (1) UA111065C2 (es)
WO (1) WO2012012764A1 (es)

Families Citing this family (28)

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US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
UA111065C2 (uk) 2010-07-23 2016-03-25 Демеркс, Інк. Композиції норибогаїну
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
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WO2013112163A1 (en) * 2012-01-25 2013-08-01 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
EP2807167A4 (en) * 2012-01-25 2016-01-20 Demerx Inc INDOIND AND BENZO FURANKED ISOCHINUCLIDEN DERIVATIVES AND METHOD FOR THE MANUFACTURE THEREOF
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US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
CA2896133A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine
CA2942638A1 (en) 2013-03-15 2014-09-18 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
EP3107546A4 (en) * 2014-02-18 2017-10-25 DemeRx, Inc. Therapeutic methods employing noribogaine and related compounds
WO2015126434A1 (en) * 2014-02-18 2015-08-27 Demerx, Inc. Methods for acute and long-term treatment of drug addiction
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
WO2015142346A1 (en) * 2014-03-20 2015-09-24 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
SI3223906T1 (sl) 2014-11-26 2021-05-31 Demerx, Inc. Postopki in sestavki za povečanje delovanja opioidnih analgetikov z uporabo alkaloidov iz iboge
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
WO2020212952A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Treatment of depression and other various disorders with psilocybin
WO2020263941A1 (en) * 2019-06-24 2020-12-30 Caamtech Llc Ibogaine formulations
US20220265675A1 (en) * 2019-07-15 2022-08-25 Demerx, Inc. Methods for the non-toxic treatment for opioid drug withdrawal combining noribogaine and cannabinoids
WO2024145464A2 (en) * 2022-12-29 2024-07-04 Atai Therapeutics, Inc: Ibogaine and noribogaine prodrugs and methods of use

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Also Published As

Publication number Publication date
EP2595632A1 (en) 2013-05-29
US9358237B2 (en) 2016-06-07
JP2017061532A (ja) 2017-03-30
US20190262351A1 (en) 2019-08-29
US20210275538A1 (en) 2021-09-09
CN103079571A (zh) 2013-05-01
US20130131046A1 (en) 2013-05-23
RU2586296C2 (ru) 2016-06-10
CA2806232A1 (en) 2012-01-26
JP6267776B2 (ja) 2018-01-24
WO2012012764A1 (en) 2012-01-26
JP2013532663A (ja) 2013-08-19
UA111065C2 (uk) 2016-03-25
RU2013102923A (ru) 2014-08-27
JP6049615B2 (ja) 2016-12-21

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