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MX2012013233A - Grupos que apuntan a receptor 2 de complemento (cr2) mejorados. - Google Patents

Grupos que apuntan a receptor 2 de complemento (cr2) mejorados.

Info

Publication number
MX2012013233A
MX2012013233A MX2012013233A MX2012013233A MX2012013233A MX 2012013233 A MX2012013233 A MX 2012013233A MX 2012013233 A MX2012013233 A MX 2012013233A MX 2012013233 A MX2012013233 A MX 2012013233A MX 2012013233 A MX2012013233 A MX 2012013233A
Authority
MX
Mexico
Prior art keywords
selectively
modulators
complement receptor
targeting groups
targeting
Prior art date
Application number
MX2012013233A
Other languages
English (en)
Inventor
James Kovacs
Jonathan P Hannan
V Michael Holers
Original Assignee
Univ Colorado Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Colorado Regents filed Critical Univ Colorado Regents
Publication of MX2012013233A publication Critical patent/MX2012013233A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

Provistas en la presente son composiciones y métodos dirigidos a proteínas solubles que pueden selectivamente entregar moduladores de actividad de complemento. Entrega apuntada de estos moduladores se logra mediante mutar selectivamente aminoácidos particulares en una porción de proteína que apunta de la composición correspondiente a por lo menos los primeros dos dominios SCR terminales N de CR2. Dependiendo de la combinación particular de mutaciones introducidas hacia la porción que apunta, un modulador de actividad de complemento puede entregarse selectivamente a ligandos particulares de CR2 en sitios donde activación o supresión de sistema de complemento se desea.
MX2012013233A 2010-05-14 2011-05-13 Grupos que apuntan a receptor 2 de complemento (cr2) mejorados. MX2012013233A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34503510P 2010-05-14 2010-05-14
PCT/US2011/036552 WO2011143637A1 (en) 2010-05-14 2011-05-13 Improved complement receptor 2 (cr2) targeting groups

Publications (1)

Publication Number Publication Date
MX2012013233A true MX2012013233A (es) 2013-05-20

Family

ID=44914740

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013233A MX2012013233A (es) 2010-05-14 2011-05-13 Grupos que apuntan a receptor 2 de complemento (cr2) mejorados.

Country Status (18)

Country Link
US (1) US9650447B2 (es)
EP (1) EP2569332B1 (es)
JP (1) JP5986990B2 (es)
KR (1) KR20130080443A (es)
CN (1) CN103038252A (es)
AU (1) AU2011252864B2 (es)
BR (1) BR112012029067A2 (es)
CA (1) CA2799192A1 (es)
CO (1) CO6650414A2 (es)
EA (1) EA201291241A1 (es)
ES (1) ES2717912T3 (es)
IL (1) IL222881A0 (es)
MX (1) MX2012013233A (es)
NZ (1) NZ603560A (es)
SG (1) SG185483A1 (es)
TR (1) TR201904224T4 (es)
WO (1) WO2011143637A1 (es)
ZA (1) ZA201208579B (es)

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AU2011252864B2 (en) 2015-11-05
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