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MX2012012902A - Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119. - Google Patents

Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119.

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Publication number
MX2012012902A
MX2012012902A MX2012012902A MX2012012902A MX2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A
Authority
MX
Mexico
Prior art keywords
gpr119
protein
novel compounds
coupled receptor
bicyclic heteroaryl
Prior art date
Application number
MX2012012902A
Other languages
English (en)
Inventor
Ying Wang
Jeffrey A Robl
Dean A Wacker
Xiang-Yang Ye
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2012012902A publication Critical patent/MX2012012902A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

La presente invención se refiere a compuestos novedosos de estructura de Fórmula I: (Ver Formula) o un enantiómero, diastereómero, tautómero, profármaco o sal de los mismos, en donde A, D, D1, E, J, L, n, Q, R2 y R4 están definidos en el presente documento, que son moduladores del receptor acoplado a proteína G GPR119. Los moduladores del receptor acoplado a proteína G GPR119 son útiles para tratar, prevenir o ralentizar la progresión de enfermedades que necesitan de terapia moduladora del receptor acoplado a proteína G GPR119. Por tanto, la descripción también se refiere a composiciones que comprenden estos compuestos novedosos y a procedimientos para tratar enfermedades o afecciones relacionadas con la actividad del receptor acoplado a proteína G GPR119 mediante el uso de cualquiera de estos compuestos novedosos o una composición que comprende cualquiera de estos compuestos novedosos.
MX2012012902A 2010-05-06 2011-05-04 Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119. MX2012012902A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33186410P 2010-05-06 2010-05-06
PCT/US2011/035086 WO2011140160A1 (en) 2010-05-06 2011-05-04 Bicyclic heteroaryl compounds as gpr119 modulators

Publications (1)

Publication Number Publication Date
MX2012012902A true MX2012012902A (es) 2012-12-17

Family

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MX2012012902A MX2012012902A (es) 2010-05-06 2011-05-04 Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119.

Country Status (10)

Country Link
US (1) US8940716B2 (es)
EP (1) EP2566860B1 (es)
JP (1) JP2013525489A (es)
CN (1) CN102971311B (es)
BR (1) BR112012028445A2 (es)
CA (1) CA2798610A1 (es)
EA (1) EA201270778A1 (es)
MX (1) MX2012012902A (es)
TW (1) TW201144306A (es)
WO (1) WO2011140160A1 (es)

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US8940716B2 (en) 2015-01-27
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