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MX2012011963A - Combinacion de un inhibidor macrociclico del virus de la hepatitis c, un no-nucleosido y un nucleosido. - Google Patents

Combinacion de un inhibidor macrociclico del virus de la hepatitis c, un no-nucleosido y un nucleosido.

Info

Publication number
MX2012011963A
MX2012011963A MX2012011963A MX2012011963A MX2012011963A MX 2012011963 A MX2012011963 A MX 2012011963A MX 2012011963 A MX2012011963 A MX 2012011963A MX 2012011963 A MX2012011963 A MX 2012011963A MX 2012011963 A MX2012011963 A MX 2012011963A
Authority
MX
Mexico
Prior art keywords
nucleoside
combination
hcv
macrocyclic
inhibitor
Prior art date
Application number
MX2012011963A
Other languages
English (en)
Inventor
Pierre Jean-Marie Bernard Raboisson
Oliver Lenz
Tse-I Lin
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of MX2012011963A publication Critical patent/MX2012011963A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se relaciona con una combinación de un inhibidor macrocíclico de la proteasa HCV, un inhibidor no-nucleósido macrocíclico de la polimerasa HCV y un inhibidor nucleósido de la polimerasa HCV.
MX2012011963A 2010-04-13 2011-04-13 Combinacion de un inhibidor macrociclico del virus de la hepatitis c, un no-nucleosido y un nucleosido. MX2012011963A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10159825 2010-04-13
PCT/EP2011/055836 WO2011128378A1 (en) 2010-04-13 2011-04-13 Combination of a macrocyclic inhibitor of hcv, a non-nucleoside and a nucleoside

Publications (1)

Publication Number Publication Date
MX2012011963A true MX2012011963A (es) 2012-12-17

Family

ID=42237337

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012011963A MX2012011963A (es) 2010-04-13 2011-04-13 Combinacion de un inhibidor macrociclico del virus de la hepatitis c, un no-nucleosido y un nucleosido.

Country Status (13)

Country Link
US (1) US20130028865A1 (es)
EP (1) EP2558091A1 (es)
JP (1) JP5989635B2 (es)
KR (1) KR20130057990A (es)
CN (1) CN102844028B (es)
AU (1) AU2011239974B2 (es)
BR (1) BR112012026016A2 (es)
CA (1) CA2796243A1 (es)
EA (1) EA201291042A1 (es)
MX (1) MX2012011963A (es)
NZ (1) NZ602552A (es)
SG (2) SG10201506652QA (es)
WO (1) WO2011128378A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
TWI454476B (zh) 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
MX2015002684A (es) * 2012-08-31 2015-05-12 Janssen Pharmaceuticals Inc Combinacion de un inhibidor macrociclico de proteasas del vhc, un inhibidor del vhc no nucleosidico y ritonavir.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005017582D1 (en) 2004-01-30 2009-12-24 Medivir Ab Hcv ns-3 serine protease inhibitoren
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
SI2084175T1 (sl) 2006-10-10 2011-05-31 Medivir Ab Hcv nukleozidni inhibitor
TWI454476B (zh) 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
AR073603A1 (es) * 2008-09-18 2010-11-17 Ortho Mcneil Janssen Pharm Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosido
AR077125A1 (es) * 2009-06-23 2011-08-03 Gilead Sciences Inc Combinaciones farmaceuticas utiles para tratar el vhc

Also Published As

Publication number Publication date
AU2011239974B2 (en) 2015-12-03
EA201291042A1 (ru) 2013-03-29
CA2796243A1 (en) 2011-10-20
SG10201506652QA (en) 2015-10-29
EP2558091A1 (en) 2013-02-20
SG184524A1 (en) 2012-11-29
AU2011239974A1 (en) 2012-10-25
CN102844028A (zh) 2012-12-26
WO2011128378A1 (en) 2011-10-20
JP2013523866A (ja) 2013-06-17
NZ602552A (en) 2014-09-26
HK1180222A1 (zh) 2013-10-18
BR112012026016A2 (pt) 2016-06-07
KR20130057990A (ko) 2013-06-03
CN102844028B (zh) 2016-04-06
US20130028865A1 (en) 2013-01-31
JP5989635B2 (ja) 2016-09-07

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