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MX2012010400A - Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados. - Google Patents

Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados.

Info

Publication number
MX2012010400A
MX2012010400A MX2012010400A MX2012010400A MX2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A
Authority
MX
Mexico
Prior art keywords
disorders
disease
compounds
pharmaceutically acceptable
disclosed
Prior art date
Application number
MX2012010400A
Other languages
English (en)
Other versions
MX339950B (es
Inventor
Neil S Cutshall
Jennifer Lynn Gage
Thomas Neil Wheeler
Thomas L Little
Original Assignee
Omeros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44560551&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012010400(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Omeros Corp filed Critical Omeros Corp
Publication of MX2012010400A publication Critical patent/MX2012010400A/es
Publication of MX339950B publication Critical patent/MX339950B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/415—1,2-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

Se describen compuestos que inhiben PDE1O que tienen utilidad en el tratamiento de una variedad de condiciones, que incluyen (pero no se limitan a) trastornos psicóticos, de ansiedad y de movimiento y/o trastornos neurológicos tal como enfermedad de Parkinson, enfermedad de Huntington, enfermedad de Alzheimer, encefalitis, fobias, epilepsia, afasia, parálisis de Bell, parálisis cerebral, trastornos de sueño, dolor, síndrome de Tourette, esquizofrenia, trastornos delirantes, psicosis inducida por drogas y trastornos de pánico y obsesivo-compulsivos. También se proporcionan sales, estereoisómeros, solvatos y profármacos farmacéuticamente aceptables de los compuestos. También se describen composiciones que contienen un compuesto en combinación con un portador farmacéuticamente aceptable, así como métodos que se refieren al uso de los mismos para inhibir PDE1O en un animal de sangre caliente en necesidad del mismo.
MX2012010400A 2010-03-12 2011-03-10 Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados. MX339950B (es)

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