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MX2012007603A - Macromolecula para el suministro de farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma, y una composicion de liberacion lenta para farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma. - Google Patents

Macromolecula para el suministro de farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma, y una composicion de liberacion lenta para farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma.

Info

Publication number
MX2012007603A
MX2012007603A MX2012007603A MX2012007603A MX2012007603A MX 2012007603 A MX2012007603 A MX 2012007603A MX 2012007603 A MX2012007603 A MX 2012007603A MX 2012007603 A MX2012007603 A MX 2012007603A MX 2012007603 A MX2012007603 A MX 2012007603A
Authority
MX
Mexico
Prior art keywords
polypeptide
protein
production method
peptide
same
Prior art date
Application number
MX2012007603A
Other languages
English (en)
Other versions
MX342712B (es
Inventor
Yil Woong Yi
Min Hyo Seo
Bong Oh Kim
In Ja Choi
Hye Jeong Yoon
Se Yoon Kim
Sang Jun Lee
Joong Woong Cho
Original Assignee
Samyang Biopharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Biopharmaceuticals filed Critical Samyang Biopharmaceuticals
Publication of MX2012007603A publication Critical patent/MX2012007603A/es
Publication of MX342712B publication Critical patent/MX342712B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/465—Preparation of carboxylic acid esters by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C07C69/68—Lactic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
    • C08J3/21—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase the polymer being premixed with a liquid phase
    • C08J3/215—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase the polymer being premixed with a liquid phase at least one additive being also premixed with a liquid phase
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

La presente se relaciona a una macromolécula para suministrar fármacos de proteína, polipéptido o péptido y a un método de producción para la misma, así como también a una composición de liberación lenta para fármacos de proteína, polipéptido o péptido que comprende la misma, y más específicamente se relaciona a un compuesto derivado de ácido poliláctico de la fórmula química 1 de la cual el peso molecular promedio en número no es más que 7,000 daltons y a un. Método de producción para el mismo, así como a una composición de liberación lenta para fármacos de proteína, polipéptido péptido que utilizan el mismo y a un método de producción para el mismo.
MX2012007603A 2009-12-29 2010-12-28 Macromolecula para el suministro de farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma, y una composicion de liberacion lenta para farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma. MX342712B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090132861 2009-12-29
PCT/KR2010/009421 WO2011081406A2 (ko) 2009-12-29 2010-12-28 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법

Publications (2)

Publication Number Publication Date
MX2012007603A true MX2012007603A (es) 2012-08-01
MX342712B MX342712B (es) 2016-10-10

Family

ID=44227011

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007603A MX342712B (es) 2009-12-29 2010-12-28 Macromolecula para el suministro de farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma, y una composicion de liberacion lenta para farmacos de proteina, polipeptido o peptido y un metodo de produccion para la misma.

Country Status (13)

Country Link
US (1) US9603931B2 (es)
EP (1) EP2520600B1 (es)
JP (1) JP5597724B2 (es)
KR (1) KR101224004B1 (es)
CN (1) CN102741317B (es)
AU (1) AU2010339080B2 (es)
BR (1) BR112012015977B1 (es)
CA (1) CA2784990C (es)
ES (1) ES2628137T3 (es)
MX (1) MX342712B (es)
NZ (1) NZ600775A (es)
PH (1) PH12012501232A1 (es)
WO (1) WO2011081406A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101424163B1 (ko) * 2010-12-24 2014-08-01 주식회사 삼양바이오팜 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법
KR101467275B1 (ko) * 2011-12-19 2014-12-02 주식회사 삼양바이오팜 분산성이 향상된 생분해성 고분자 미립자의 조성물 및 그 제조방법
KR101547633B1 (ko) 2013-06-21 2015-08-26 가톨릭대학교 산학협력단 약물 전달용 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법
KR101547634B1 (ko) 2013-06-21 2015-08-26 가톨릭대학교 산학협력단 약물 전달용 환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법
JP6139029B2 (ja) * 2013-06-21 2017-05-31 ザ カトリック ユニバーシティ オブ コリア インダストリー−アカデミック コーオペレイション ファウンデーション 薬物送達用還元性または非還元性ポリヌクレオチド高分子及びその製造方法
ZA201407536B (en) * 2013-10-21 2017-09-27 Ems Sa Parenteral pharmaceutical composition containing cosyntropin
JP6637484B2 (ja) * 2014-08-07 2020-01-29 ザ ジェネラル ホスピタル コーポレイション 血小板を標的とするマイクロ流体細胞単離
US10160896B2 (en) 2015-04-27 2018-12-25 Halliburton Energy Services, Inc. Delayed-release additives in a degradable matrix
KR101547636B1 (ko) 2015-07-20 2015-08-27 가톨릭대학교 산학협력단 환원성 폴리뉴클레오타이드 고분자를 포함하는 비바이러스성 약물전달용 조성물
KR101547635B1 (ko) 2015-07-20 2015-08-27 가톨릭대학교 산학협력단 비환원성 폴리뉴클레오타이드 고분자를 포함하는 비바이러스성 약물전달용 조성물
CN108660614B (zh) * 2018-05-22 2020-04-03 西南交通大学 一种聚乳酸多孔薄膜及其制备方法
EP4442728A4 (en) * 2021-11-30 2025-10-01 Nisshinbo Holdings Inc MARINE BIODEGRADABLE POLYMER COMPOUND, MARINE BIODEGRADATION PROMOTER AND MARINE BIODEGRADABLE RESIN COMPOSITION

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE556559A (es) * 1956-04-13
JPS62135521A (ja) 1985-12-10 1987-06-18 Daicel Chem Ind Ltd 末端にカルボキシル基を有するポリカプロラクトン
JPS6369825A (ja) * 1986-09-11 1988-03-29 Mitsui Toatsu Chem Inc ブロツク共重合体及びその製造方法
US5196502A (en) * 1991-11-05 1993-03-23 Eastman Kodak Company Method for the preparation of multiply-branched aromatic polyesters
EP0678018B1 (en) * 1993-01-06 2003-04-09 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US6221958B1 (en) 1993-01-06 2001-04-24 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
JP3287425B2 (ja) * 1993-02-04 2002-06-04 東洋紡績株式会社 水酸基末端をエステル封鎖したポリ乳酸およびその製造法
KR0141431B1 (ko) 1994-05-17 1998-07-01 김상웅 생분해성 하이드로겔 고분자
JPH0859642A (ja) 1994-08-22 1996-03-05 Mitsubishi Chem Corp ３，４−アルキレン−１，３，４−チアジアゾリジン−２−オン類の製造方法
US5668288A (en) 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
ZA9711385B (en) 1996-12-20 1999-06-18 Takeda Chemical Industries Ltd Method of producing a sustained-release preparation
JPH1121343A (ja) * 1997-07-01 1999-01-26 Mitsui Chem Inc ポリヒドロキシカルボン酸の製造方法
JPH1160928A (ja) * 1997-08-27 1999-03-05 Nishikawa Rubber Co Ltd ポリヒドロキシカルボン酸樹脂組成物およびその製造方法
US6541033B1 (en) 1998-06-30 2003-04-01 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of leptin
ATE370988T1 (de) * 2001-10-18 2007-09-15 Samyang Corp Polymermicellenzusammensetzung mit verbesserter stabilität
MXPA04003513A (es) * 2001-10-18 2004-07-23 Samyang Corp Derivados de acido polilactico biodegradables, sensibles al ph, que forman micelas polimericas y usos de los mismos para el suministro de farmacos deficientemente solubles en agua.
KR100829799B1 (ko) 2004-05-06 2008-05-16 주식회사 삼양사 양친성 블록 공중합체 및 폴리락트산 유도체를 포함하는 고분자 약물 담체에 기초한 생물 활성제의 세포내 전달용 조성물
US7655735B2 (en) * 2004-08-02 2010-02-02 Samyang Corporation Biodegradable multi-block polymeric composition capable of sol-gel transition and pharmaceutical composition comprising the same
EP1647567A1 (en) 2004-10-15 2006-04-19 SOLVAY (Société Anonyme) Methods of producing amine-terminated caprolactone polymers and uses of the produced polymers
CN101104706A (zh) * 2007-08-06 2008-01-16 四川大学 聚乳酸及其衍生物的电子束辐射改性方法
KR101024742B1 (ko) 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법

Also Published As

Publication number Publication date
EP2520600B1 (en) 2017-03-29
AU2010339080B2 (en) 2015-09-17
MX342712B (es) 2016-10-10
AU2010339080A9 (en) 2015-09-17
AU2010339080A1 (en) 2012-07-19
CN102741317A (zh) 2012-10-17
US9603931B2 (en) 2017-03-28
WO2011081406A2 (ko) 2011-07-07
ES2628137T3 (es) 2017-08-01
NZ600775A (en) 2015-01-30
CA2784990A1 (en) 2011-07-07
KR20110076783A (ko) 2011-07-06
CN102741317B (zh) 2015-01-07
JP5597724B2 (ja) 2014-10-01
BR112012015977A2 (pt) 2018-05-29
JP2013515833A (ja) 2013-05-09
WO2011081406A3 (ko) 2011-12-01
EP2520600A2 (en) 2012-11-07
EP2520600A4 (en) 2014-01-08
US20130274188A1 (en) 2013-10-17
CA2784990C (en) 2015-03-31
PH12012501232A1 (en) 2016-09-09
BR112012015977B1 (pt) 2020-10-06
KR101224004B1 (ko) 2013-01-22

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