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MX2012006485A - Piridinon hidroxiclicopentil carboxamidas: inhibidores de la integrasa del vih con aplicaciones terapeuticas. - Google Patents

Piridinon hidroxiclicopentil carboxamidas: inhibidores de la integrasa del vih con aplicaciones terapeuticas.

Info

Publication number
MX2012006485A
MX2012006485A MX2012006485A MX2012006485A MX2012006485A MX 2012006485 A MX2012006485 A MX 2012006485A MX 2012006485 A MX2012006485 A MX 2012006485A MX 2012006485 A MX2012006485 A MX 2012006485A MX 2012006485 A MX2012006485 A MX 2012006485A
Authority
MX
Mexico
Prior art keywords
hiv
compounds
pyridinone
methods
carboxamides
Prior art date
Application number
MX2012006485A
Other languages
English (en)
Inventor
Vasu Nair
Maurice O Okello
Abdumalik A Nishonov
Sanjaykumar Mishra
Original Assignee
Univ Georgia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia filed Critical Univ Georgia
Publication of MX2012006485A publication Critical patent/MX2012006485A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen nuevas ciclopentil piridinon dicetocarboxamidas sustituidas con oxi, quirales y aquirales, y sus derivados y métodos para sus preparaciones. Los compuestos incluyen tautómeros, regioisómeros e isómeros geométricos. Estas carboxamidas complejas se diseñan como inhibidores de la replicación del VIH a través de la inhibición de la integrasa del VIH. Los compuestos son útiles en la prevención o tratamiento de la infección por el VIH y en el tratamiento del SIDA y el Complejo Relacionado con el SIDA (ARC, por sus siglas en inglés), ya sea como los compuestos, o como sales farmacéuticamente aceptables, con portadores farmacéuticamente aceptables, utilizados solos o en combinación con antivirales, inmunomoduladores, antibióticos, vacunas y otros agentes terapéuticos, especialmente otros compuestos anti-VIH (incluyendo otros agentes anti-integrasa del VIH), que pueden utilizarse para crear preparaciones combinadas anti-VIH. También se describen métodos para tratar el SIDA y el ARC y métodos para tratar o prevenir la infección por VIH.
MX2012006485A 2009-12-07 2010-12-07 Piridinon hidroxiclicopentil carboxamidas: inhibidores de la integrasa del vih con aplicaciones terapeuticas. MX2012006485A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28367509P 2009-12-07 2009-12-07
US32042910P 2010-04-02 2010-04-02
PCT/US2010/059183 WO2011071849A2 (en) 2009-12-07 2010-12-07 Pyridinone hydroxycyclopentyl carboxamides: hiv integrase inhibitors with therapeutic applications

Publications (1)

Publication Number Publication Date
MX2012006485A true MX2012006485A (es) 2012-08-23

Family

ID=44146132

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012006485A MX2012006485A (es) 2009-12-07 2010-12-07 Piridinon hidroxiclicopentil carboxamidas: inhibidores de la integrasa del vih con aplicaciones terapeuticas.

Country Status (16)

Country Link
US (1) US8703801B2 (es)
EP (1) EP2509949B1 (es)
JP (1) JP2013512957A (es)
KR (1) KR20120094098A (es)
CN (1) CN102753526B (es)
AU (1) AU2010328325B2 (es)
CA (1) CA2783540C (es)
EA (1) EA201270651A1 (es)
IL (1) IL220113A0 (es)
MX (1) MX2012006485A (es)
MY (1) MY172005A (es)
NZ (1) NZ600873A (es)
PH (1) PH12012501095A1 (es)
SG (1) SG181524A1 (es)
WO (1) WO2011071849A2 (es)
ZA (1) ZA201204147B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012006485A (es) 2009-12-07 2012-08-23 Univ Georgia Piridinon hidroxiclicopentil carboxamidas: inhibidores de la integrasa del vih con aplicaciones terapeuticas.
KR101406201B1 (ko) * 2011-10-19 2014-06-12 한국생명공학연구원 인제난 타입의 디테르펜 화합물 및 이를 포함하는 바이러스 감염 질환의 치료 또는 예방용 약학적 조성물
EP3578563B1 (en) 2011-12-22 2021-04-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
WO2013148174A1 (en) 2012-03-31 2013-10-03 University Of Georgia Research Foundation, Inc. New anti-mycobacterial drugs against tuberculosis
CN103524396B (zh) * 2012-09-29 2018-05-25 中国医学科学院医药生物技术研究所 含吲哚环的二脒类衍生物及其制备方法和应用
JP6767011B2 (ja) * 2015-09-18 2020-10-14 ヤマサ醤油株式会社 抗ｄｎａウィルス活性などの生理活性を有するヌクレオシド誘導体
JP2019502363A (ja) 2015-10-30 2019-01-31 エヌビーイー セラピューティクス アクチェン ゲゼルシャフト 抗ｒｏｒ１抗体
UA125718C2 (uk) 2016-01-20 2022-05-25 Зе Скріппс Ресеарч Інстітьют Композиції антитіл до ror1 і пов'язані з ними способи
WO2019030240A1 (en) 2017-08-07 2019-02-14 Nbe-Therapeutics Ag ANTIBODIES BINDING TO A LINEAR HUMAN CS1 EPITOPE

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Also Published As

Publication number Publication date
CA2783540A1 (en) 2011-06-16
CN102753526B (zh) 2014-11-26
SG181524A1 (en) 2012-07-30
US8703801B2 (en) 2014-04-22
EP2509949A4 (en) 2013-04-17
PH12012501095A1 (en) 2015-04-22
ZA201204147B (en) 2013-02-27
NZ600873A (en) 2014-08-29
JP2013512957A (ja) 2013-04-18
EA201270651A1 (ru) 2013-01-30
MY172005A (en) 2019-11-11
CN102753526A (zh) 2012-10-24
AU2010328325B2 (en) 2015-02-05
KR20120094098A (ko) 2012-08-23
EP2509949A2 (en) 2012-10-17
WO2011071849A3 (en) 2011-10-06
AU2010328325A1 (en) 2012-06-21
WO2011071849A2 (en) 2011-06-16
US20120282218A1 (en) 2012-11-08
EP2509949B1 (en) 2014-04-23
CA2783540C (en) 2018-04-24
IL220113A0 (en) 2012-07-31

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