MX2012002842A - Metodo para fabricar derivado de acido 4-(5-metilpiridin-2.iloamin o) piperidin-1-carboxilico. - Google Patents
Metodo para fabricar derivado de acido 4-(5-metilpiridin-2.iloamin o) piperidin-1-carboxilico.Info
- Publication number
- MX2012002842A MX2012002842A MX2012002842A MX2012002842A MX2012002842A MX 2012002842 A MX2012002842 A MX 2012002842A MX 2012002842 A MX2012002842 A MX 2012002842A MX 2012002842 A MX2012002842 A MX 2012002842A MX 2012002842 A MX2012002842 A MX 2012002842A
- Authority
- MX
- Mexico
- Prior art keywords
- reaction
- ylamino
- iron core
- bearing
- useful process
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 10
- MQYBDLQMUYLPTC-UHFFFAOYSA-N 4-[(5-methylpyridin-2-yl)amino]piperidine-1-carboxylic acid Chemical class N1=CC(C)=CC=C1NC1CCN(C(O)=O)CC1 MQYBDLQMUYLPTC-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 5
- -1 aromatic monocyclic hydrocarbon Chemical class 0.000 abstract 4
- 239000012530 fluid Substances 0.000 abstract 4
- ZHESHQYMQHBMLD-UHFFFAOYSA-N 5-methyl-n-piperidin-4-ylpyridin-2-amine Chemical compound N1=CC(C)=CC=C1NC1CCNCC1 ZHESHQYMQHBMLD-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- 238000005260 corrosion Methods 0.000 abstract 2
- 230000007797 corrosion Effects 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 238000009776 industrial production Methods 0.000 abstract 2
- 238000003780 insertion Methods 0.000 abstract 2
- 230000037431 insertion Effects 0.000 abstract 2
- 230000002093 peripheral effect Effects 0.000 abstract 2
- 239000012429 reaction media Substances 0.000 abstract 2
- 239000012279 sodium borohydride Substances 0.000 abstract 2
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 2
- 239000012321 sodium triacetoxyborohydride Substances 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Motor Or Generator Frames (AREA)
Abstract
Es establece un método novedoso para fabricar 5-metil-2- (piperidin-4-ilamino) piridina. Este método puede usarse como un método de fabricación industrial para producir un derivado de ácido 4-(5-metilpiridin-2-ilamino)piperidin-1-carboxílico representado por la fórmula general, (ver fórmulas) en donde R representa un grupo alquilo lineal o ramificado que tiene 1 hasta 6 átomos de carbono o un grupo aralquilo que tiene 7 hasta 12 átomos de carbono en una solución de reacción que tiene un hidrocarburo monociclico aromático como un medio de reacción, en presencia de triacetoxiborohidruro de sodio como un agente reductor, o después de agregar borohidruro de sodio y ácido acético a la solución de reacción con anticipación.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009207408 | 2009-09-08 | ||
| PCT/JP2010/005489 WO2011030537A1 (ja) | 2009-09-08 | 2010-09-07 | ４－（５－メチルピリジン－２－イルアミノ）ピペリジン－１－カルボン酸誘導体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012002842A true MX2012002842A (es) | 2012-04-19 |
Family
ID=43732217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012002842A MX2012002842A (es) | 2009-09-08 | 2010-09-07 | Metodo para fabricar derivado de acido 4-(5-metilpiridin-2.iloamin o) piperidin-1-carboxilico. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120142932A1 (es) |
| EP (1) | EP2476677A1 (es) |
| JP (1) | JPWO2011030537A1 (es) |
| KR (1) | KR20120069710A (es) |
| CN (1) | CN102498108A (es) |
| BR (1) | BR112012003324A2 (es) |
| CA (1) | CA2773464A1 (es) |
| MX (1) | MX2012002842A (es) |
| TW (1) | TW201114758A (es) |
| WO (1) | WO2011030537A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119275352B (zh) * | 2024-11-26 | 2025-09-19 | 大连中比动力电池有限公司 | 一种锂电池用低温电解液 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG12406A (en) * | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| GB0030303D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| ATE417845T1 (de) * | 2001-10-09 | 2009-01-15 | Kyorin Seiyaku Kk | Neue 4-(2-furoyl)-amino-piperidine, zwischenprodukte für deren synthese, verfahren zu deren herstellung und deren medizinische verwendung |
| UA82711C2 (en) * | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
| GB0508318D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| WO2006114706A1 (en) * | 2005-04-26 | 2006-11-02 | Pfizer Limited | Triazole derivatives as vasopressin antagonists |
| EP2397477B1 (en) | 2007-01-16 | 2014-03-05 | Purdue Pharma LP | Heterocyclic-substituted piperidine compounds and the uses thereof |
-
2010
- 2010-09-07 BR BRBR112012003324-7A patent/BR112012003324A2/pt not_active IP Right Cessation
- 2010-09-07 CA CA2773464A patent/CA2773464A1/en not_active Abandoned
- 2010-09-07 WO PCT/JP2010/005489 patent/WO2011030537A1/ja not_active Ceased
- 2010-09-07 KR KR1020127008853A patent/KR20120069710A/ko not_active Withdrawn
- 2010-09-07 EP EP10815137A patent/EP2476677A1/en not_active Withdrawn
- 2010-09-07 CN CN2010800406299A patent/CN102498108A/zh active Pending
- 2010-09-07 US US13/386,698 patent/US20120142932A1/en not_active Abandoned
- 2010-09-07 JP JP2011530746A patent/JPWO2011030537A1/ja active Pending
- 2010-09-07 MX MX2012002842A patent/MX2012002842A/es unknown
- 2010-09-08 TW TW099130282A patent/TW201114758A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2773464A1 (en) | 2011-03-17 |
| BR112012003324A2 (pt) | 2015-09-01 |
| WO2011030537A1 (ja) | 2011-03-17 |
| EP2476677A1 (en) | 2012-07-18 |
| TW201114758A (en) | 2011-05-01 |
| CN102498108A (zh) | 2012-06-13 |
| JPWO2011030537A1 (ja) | 2013-02-04 |
| US20120142932A1 (en) | 2012-06-07 |
| KR20120069710A (ko) | 2012-06-28 |
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