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MX2012000431A - Procedimientos para 3-amino-5-oxo-4,5-dihidro-[1,2,4]triazinas sustituidas. - Google Patents

Procedimientos para 3-amino-5-oxo-4,5-dihidro-[1,2,4]triazinas sustituidas.

Info

Publication number
MX2012000431A
MX2012000431A MX2012000431A MX2012000431A MX2012000431A MX 2012000431 A MX2012000431 A MX 2012000431A MX 2012000431 A MX2012000431 A MX 2012000431A MX 2012000431 A MX2012000431 A MX 2012000431A MX 2012000431 A MX2012000431 A MX 2012000431A
Authority
MX
Mexico
Prior art keywords
amino
dihydro
oxo
triazine
substituted
Prior art date
Application number
MX2012000431A
Other languages
English (en)
Inventor
Hanqing Dong
Kristen Michelle Mulvihill
Douglas S Werner
Josef A Rechka
Yunyu Mao
Original Assignee
Osi Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharmaceuticals Llc filed Critical Osi Pharmaceuticals Llc
Publication of MX2012000431A publication Critical patent/MX2012000431A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Procedimientos incluyendo la preparación de metil éster del ácido trans-4-[(3-amino-5-oxo-4,5-dihidro-[1,2,4]triazin-6-ilmetil)-car bamoil]-ciclohexanocarboxilico, y su conversión a compuestos del ácido trans-4-(4-amino-5-sustituido-imidazo[5,1-f][1,2,4]triazin-7 -il)-ciclohexanocarboxlico.
MX2012000431A 2009-07-09 2010-07-08 Procedimientos para 3-amino-5-oxo-4,5-dihidro-[1,2,4]triazinas sustituidas. MX2012000431A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22409009P 2009-07-09 2009-07-09
PCT/US2010/041278 WO2011005909A2 (en) 2009-07-09 2010-07-08 Process for substituted 3-amino-5-oxo-4,5-dihydro-[1,2,4]triazines

Publications (1)

Publication Number Publication Date
MX2012000431A true MX2012000431A (es) 2012-02-21

Family

ID=43429828

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000431A MX2012000431A (es) 2009-07-09 2010-07-08 Procedimientos para 3-amino-5-oxo-4,5-dihidro-[1,2,4]triazinas sustituidas.

Country Status (9)

Country Link
US (1) US20120108812A1 (es)
EP (1) EP2451792A4 (es)
JP (1) JP2012532882A (es)
KR (1) KR20120047256A (es)
CN (1) CN102471292A (es)
BR (1) BR112012000494A2 (es)
CA (1) CA2764173A1 (es)
MX (1) MX2012000431A (es)
WO (1) WO2011005909A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101316845A (zh) 2005-11-17 2008-12-03 Osi医药有限公司 稠合双环mTOR抑制剂
CN101977912A (zh) 2008-03-19 2011-02-16 Osi医药有限公司 mTOR抑制剂的盐形式
UA106692C2 (uk) 2011-02-23 2014-09-25 Пфайзер Інк. ІМІДАЗО[5,1-f][1,2,4]ТРИАЗИНИ ДЛЯ ЛІКУВАННЯ НЕВРОЛОГІЧНИХ РОЗЛАДІВ
CN114507234A (zh) * 2020-10-13 2022-05-17 上海健康医学院 11c标记osi-027化合物及其制备方法及应用
WO2023229605A1 (en) * 2022-05-27 2023-11-30 Avalo Therapeutics, Inc. Methods and treatment for complex lymphatic malformations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101316845A (zh) * 2005-11-17 2008-12-03 Osi医药有限公司 稠合双环mTOR抑制剂
WO2007106503A2 (en) * 2006-03-13 2007-09-20 Osi Pharmaceuticals, Inc. Combined treatment with an egfr kinase inhibitor and an agent that sensitizes tumor cells to the effects of egfr kinase inhibitors
EP2178563A2 (en) * 2007-07-06 2010-04-28 OSI Pharmaceuticals, Inc. Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mtorc2

Also Published As

Publication number Publication date
CN102471292A (zh) 2012-05-23
WO2011005909A3 (en) 2011-05-12
CA2764173A1 (en) 2011-01-13
JP2012532882A (ja) 2012-12-20
US20120108812A1 (en) 2012-05-03
KR20120047256A (ko) 2012-05-11
BR112012000494A2 (pt) 2015-09-15
EP2451792A4 (en) 2013-03-06
WO2011005909A2 (en) 2011-01-13
EP2451792A2 (en) 2012-05-16

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