MX2011012013A - Peptidos ttk y vacunas que incluyen los mismos. - Google Patents
Peptidos ttk y vacunas que incluyen los mismos.Info
- Publication number
- MX2011012013A MX2011012013A MX2011012013A MX2011012013A MX2011012013A MX 2011012013 A MX2011012013 A MX 2011012013A MX 2011012013 A MX2011012013 A MX 2011012013A MX 2011012013 A MX2011012013 A MX 2011012013A MX 2011012013 A MX2011012013 A MX 2011012013A
- Authority
- MX
- Mexico
- Prior art keywords
- peptides
- ttk
- methods
- antigen
- inducing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen vacunas de péptido contra cáncer. En particular, se proporcionan péptidos de epitopo derivados del gen TTK que producen CTLs. También se proporcionan células que presentan antígenos y CTLs aislados que se dirigen a tales péptidos, así como métodos para inducir la célula que presenta antígeno, o CTL. La presente invención proporciona además composiciones farmacéuticas que contienen como péptidos de ingredientes activos derivados de TTK o polinucleótidos que codifican los péptidos. Adicionalmente, la presente invención proporciona métodos para el tratamiento y/o profilaxis (es decir, prevención) de cánceres (tumores), y/o la prevención de recurrencía postoperativa de los mismos, así como métodos para inducir CTLs, métodos para inducir inmunidad anti-tumor, usando los péptidos derivados de TTK, polinucleótidos que codifican los péptidos, o células que presentan antígeno que presentan los péptidos, o las composiciones farmacéuticas de la presente invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21601709P | 2009-05-11 | 2009-05-11 | |
| PCT/JP2010/003166 WO2010131452A1 (en) | 2009-05-11 | 2010-05-10 | Ttk peptides and vaccines including the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011012013A true MX2011012013A (es) | 2012-02-23 |
Family
ID=43084837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011012013A MX2011012013A (es) | 2009-05-11 | 2010-05-10 | Peptidos ttk y vacunas que incluyen los mismos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8530430B2 (es) |
| EP (1) | EP2430039A4 (es) |
| JP (1) | JP5786178B2 (es) |
| KR (1) | KR20120029394A (es) |
| CN (1) | CN102459314B (es) |
| AU (1) | AU2010248702A1 (es) |
| BR (1) | BRPI1013938A2 (es) |
| CA (1) | CA2761393A1 (es) |
| MX (1) | MX2011012013A (es) |
| RU (1) | RU2531348C2 (es) |
| SG (1) | SG175998A1 (es) |
| TW (1) | TW201102081A (es) |
| WO (1) | WO2010131452A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6283861B2 (ja) * | 2012-09-11 | 2018-02-28 | オンコセラピー・サイエンス株式会社 | Ｕｂｅ２ｔペプチドおよびそれを含むワクチン |
| CN110214144B (zh) * | 2016-11-16 | 2023-05-02 | 深圳华大生命科学研究院 | 多肽及其应用 |
| CN109952308B (zh) | 2016-11-29 | 2022-09-23 | 武汉华大吉诺因生物科技有限公司 | 多肽及其应用 |
| MX2020000413A (es) * | 2017-07-12 | 2020-09-28 | Nouscom Ag | Una vacuna universal basada en neoantigenos de tumor compartidos para prevencion y tratamiento de canceres inestables de microsatelite (msi). |
| WO2024077601A1 (en) * | 2022-10-14 | 2024-04-18 | Guangdong Tcrcure Biopharma Technology Co., Ltd. | Peptide vaccines against glioma and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187548B1 (en) * | 1993-05-23 | 2001-02-13 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Methods using human calcium sensor protein, fragments thereof and DNA encoding same |
| US20030045491A1 (en) | 2001-02-23 | 2003-03-06 | Christoph Reinhard | TTK in diagnosis and as a therapeutic target in cancer |
| US7501243B2 (en) * | 2001-02-21 | 2009-03-10 | Novartis Vaccines And Diagnostics, Inc. | Detection of colon or breast cancer by measuring TTK polypeptide expression |
| CN101732717A (zh) * | 2001-02-21 | 2010-06-16 | 诺华疫苗和诊断公司 | 用于诊断和作为癌症治疗靶标的ttk |
| JP2005527180A (ja) | 2001-04-18 | 2005-09-15 | プロテイン デザイン ラブス， インコーポレイテッド | 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法 |
| EP1485871A2 (en) * | 2002-02-27 | 2004-12-15 | Michael Rik Frans Brands | A data integration and knowledge management solution |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| ES2309485T3 (es) | 2003-01-06 | 2008-12-16 | Wyeth | Composiciones y procedimientos para diagnosticar y tratar los canceres de colon. |
| US20050266409A1 (en) | 2003-02-04 | 2005-12-01 | Wyeth | Compositions and methods for diagnosing, preventing, and treating cancers |
| AU2003224132A1 (en) | 2003-04-24 | 2004-11-19 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
| AU2004276823A1 (en) | 2003-09-22 | 2005-04-07 | Merck And Co., Inc | Synthetic lethal screen using RNA interference |
| JP4721903B2 (ja) | 2004-01-29 | 2011-07-13 | 大日本住友製薬株式会社 | 新規腫瘍抗原蛋白質及びその利用 |
| GB0426393D0 (en) | 2004-12-01 | 2005-01-05 | Cancer Rec Tech Ltd | Materials and methods relating to modulators of spindle checkpoint kinases |
| EP2395106A1 (en) | 2004-12-08 | 2011-12-14 | Aventis Pharmaceuticals Inc. | Method for measuring resistance or sensitivity to docetaxel |
| JP5109131B2 (ja) | 2005-02-10 | 2012-12-26 | オンコセラピー・サイエンス株式会社 | 膀胱癌を診断する方法 |
| EP2325306B1 (en) | 2005-02-25 | 2014-02-12 | Oncotherapy Science, Inc. | Peptide vaccines for lung cancers expressing TTK, URLC10 or KOC1 polypeptides |
| EP2298895A1 (en) | 2005-07-27 | 2011-03-23 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| US8053183B2 (en) | 2005-07-27 | 2011-11-08 | Oncotherapy Science, Inc. | Method of diagnosing esophageal cancer |
| EP2468887A1 (en) | 2006-12-13 | 2012-06-27 | Oncotherapy Science, Inc. | TTK as tumor marker and therapeutic target for lung cancer |
| TWI596109B (zh) * | 2007-02-21 | 2017-08-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| CA2708686A1 (en) | 2007-12-21 | 2009-07-02 | University Health Network | Methods of inhibiting tumor growth using ttk antagonists |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2010
- 2010-05-05 TW TW099114328A patent/TW201102081A/zh unknown
- 2010-05-10 WO PCT/JP2010/003166 patent/WO2010131452A1/en not_active Ceased
- 2010-05-10 MX MX2011012013A patent/MX2011012013A/es active IP Right Grant
- 2010-05-10 EP EP10774711A patent/EP2430039A4/en not_active Withdrawn
- 2010-05-10 JP JP2011548451A patent/JP5786178B2/ja not_active Expired - Fee Related
- 2010-05-10 RU RU2011150283/04A patent/RU2531348C2/ru not_active IP Right Cessation
- 2010-05-10 US US13/320,022 patent/US8530430B2/en not_active Expired - Fee Related
- 2010-05-10 CN CN201080031259.2A patent/CN102459314B/zh not_active Expired - Fee Related
- 2010-05-10 CA CA2761393A patent/CA2761393A1/en not_active Abandoned
- 2010-05-10 AU AU2010248702A patent/AU2010248702A1/en not_active Abandoned
- 2010-05-10 BR BRPI1013938A patent/BRPI1013938A2/pt not_active IP Right Cessation
- 2010-05-10 KR KR1020117027534A patent/KR20120029394A/ko not_active Withdrawn
- 2010-05-10 SG SG2011082963A patent/SG175998A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2531348C2 (ru) | 2014-10-20 |
| JP2012526519A (ja) | 2012-11-01 |
| CN102459314B (zh) | 2016-01-20 |
| RU2011150283A (ru) | 2013-06-20 |
| EP2430039A1 (en) | 2012-03-21 |
| JP5786178B2 (ja) | 2015-09-30 |
| EP2430039A4 (en) | 2012-12-05 |
| CA2761393A1 (en) | 2010-11-18 |
| US8530430B2 (en) | 2013-09-10 |
| US20120135020A1 (en) | 2012-05-31 |
| WO2010131452A1 (en) | 2010-11-18 |
| KR20120029394A (ko) | 2012-03-26 |
| BRPI1013938A2 (pt) | 2019-09-24 |
| CN102459314A (zh) | 2012-05-16 |
| AU2010248702A1 (en) | 2011-11-17 |
| TW201102081A (en) | 2011-01-16 |
| SG175998A1 (en) | 2011-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |