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MX2010013758A - Procedimiento para elaborar 2-amino-tiazolonas sustituidas. - Google Patents

Procedimiento para elaborar 2-amino-tiazolonas sustituidas.

Info

Publication number
MX2010013758A
MX2010013758A MX2010013758A MX2010013758A MX2010013758A MX 2010013758 A MX2010013758 A MX 2010013758A MX 2010013758 A MX2010013758 A MX 2010013758A MX 2010013758 A MX2010013758 A MX 2010013758A MX 2010013758 A MX2010013758 A MX 2010013758A
Authority
MX
Mexico
Prior art keywords
thiazolones
amino
making substituted
contacting
salt
Prior art date
Application number
MX2010013758A
Other languages
English (en)
Inventor
A Moniz George
J Frizzle Matthew
Bernard Charles
Martinelli Michael
Faul Margaret
Larrow Jay
B Hansen Karl
Klingensmith Liane
Original Assignee
Amgen Inc Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41550939&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010013758(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc Star filed Critical Amgen Inc Star
Publication of MX2010013758A publication Critical patent/MX2010013758A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona con métodos para elaborar compuestos que inhiben la enzima tipo 1 de deshidrogenasa 11-ß-hidroxiesteroide (11-ß HSD1). Un método que comprende (a) poner en contacto un compuesto de la fórmula (II) con una base quiral, un agente para desprotonación, y un agente alquilante R3-LG, (b) poner en contacto el producto de (a) con un ácido para formar una sal, y (c) hacer reaccionar la sal con una base para formar el compuesto de la fórmula (I) en donde Z, R1, R2, y R3 se definen en la misma.
MX2010013758A 2008-06-20 2009-06-16 Procedimiento para elaborar 2-amino-tiazolonas sustituidas. MX2010013758A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7434508P 2008-06-20 2008-06-20
PCT/US2009/047469 WO2010008729A2 (en) 2008-06-20 2009-06-16 Process for making substituted 2-amino-thiazolones

Publications (1)

Publication Number Publication Date
MX2010013758A true MX2010013758A (es) 2011-03-02

Family

ID=41550939

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010013758A MX2010013758A (es) 2008-06-20 2009-06-16 Procedimiento para elaborar 2-amino-tiazolonas sustituidas.

Country Status (15)

Country Link
US (1) US8536345B2 (es)
EP (1) EP2303854A2 (es)
JP (1) JP2011524914A (es)
KR (1) KR20110041462A (es)
CN (1) CN102066346A (es)
AU (1) AU2009271404A1 (es)
BR (1) BRPI0915177A2 (es)
CA (1) CA2727674A1 (es)
CL (1) CL2010001441A1 (es)
EA (1) EA018028B1 (es)
IL (1) IL209970A0 (es)
MX (1) MX2010013758A (es)
SG (1) SG192422A1 (es)
WO (1) WO2010008729A2 (es)
ZA (1) ZA201009104B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5869222B2 (ja) 2008-01-04 2016-02-24 インテリカイン， エルエルシー 特定の化学的実体、組成物および方法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US20130310431A1 (en) 2010-10-15 2013-11-21 Amgen Inc Uses for substituted 2-amino-thiazolones in treating alzheimer's disease
MX347708B (es) 2011-01-10 2017-05-09 Infinity Pharmaceuticals Inc Proceso para preparar isoquinolinonas y formas solidas de isoquinolinonas.
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
MX391135B (es) 2016-06-24 2025-03-21 Infinity Pharmaceuticals Inc Terapias de combinacion.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407124B1 (en) * 1998-06-18 2002-06-18 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
ATE417837T1 (de) 2004-05-24 2009-01-15 Amgen Inc Inhibitoren von 11-beta- hydroxysteroiddehydrogenase typ 1
WO2007061661A2 (en) 2005-11-22 2007-05-31 Amgen Inc. Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
JP5411850B2 (ja) * 2007-06-21 2014-02-12 アムジエン・インコーポレーテツド 置換２−アミノ−チアゾロンを作製するための方法

Also Published As

Publication number Publication date
BRPI0915177A2 (pt) 2016-04-26
SG192422A1 (en) 2013-08-30
WO2010008729A3 (en) 2010-05-06
US20110160463A1 (en) 2011-06-30
CA2727674A1 (en) 2010-01-21
ZA201009104B (en) 2011-09-28
WO2010008729A2 (en) 2010-01-21
US8536345B2 (en) 2013-09-17
EA201170057A1 (ru) 2011-08-30
EA018028B1 (ru) 2013-04-30
IL209970A0 (en) 2011-02-28
JP2011524914A (ja) 2011-09-08
CN102066346A (zh) 2011-05-18
AU2009271404A1 (en) 2010-01-21
CL2010001441A1 (es) 2011-04-29
KR20110041462A (ko) 2011-04-21
EP2303854A2 (en) 2011-04-06

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